Treating Stimulant Addiction with Repetitive Transcranial Magnetic Stimulation

通过重复经颅磁刺激治疗兴奋剂成瘾

• 批准号: 10471799
• 负责人: JONG H YOON
• 金额: --
• 依托单位: VETERANS ADMIN PALO ALTO HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10471799
• 关键词: Abstinence; Adaptive Behaviors; Affective; Aftercare; Amphetamines; Behavioral; Biological Markers; Brain; Brain region; Clinical; Cocaine; Cognitive; Controlled Study; Data; Development; Dopamine; Double-Blind Method; FDA approved; Feasibility Studies; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Health; Homelessness; Intervention; Left; Legal; Major Depressive Disorder; Measures; Methamphetamine use disorder; Methods; Morbidity - disease rate; Occupational; Participant; Patient Selection; Personal Satisfaction; Pharmaceutical Preparations; Placebos; Prediction of Response to Therapy; Prefrontal Cortex; Process; Property; Psychopathology; Randomized; Refractory; Relapse; Research Design; Rewards; Role; Services; Signal Transduction; Stimulant; Suicide; Toxicology; Urine; Veterans; adaptive learning; addiction; base; cost effective; design; disability; drug of abuse; functional MRI scan; functional status; improved; magnetic field; neuropsychiatry; psychosocial; randomized controlled study; relapse prediction; relating to nervous system; repetitive transcranial magnetic stimulation; reward processing; sham-controlled study; social deficits; stimulant dependence; stimulant use; stimulant use disorder; treatment comparison; treatment group

Stimulant use disorder accounts for significant disability and dysfunction among Veterans. We currently do not have effective somatic treatments for this condition. This proposal will conduct a feasibility study to determine our ability to administer and complete a double-blind, sham-controlled randomized study using repetitive transcranial stimulation (rTMS) for treating stimulant use disorder. Half of the participants will be randomly assigned to receive sham treatment and the other half to receive active rTMS to the dorsolateral prefrontal cortex (DLPFC). We will also obtain pilot data supporting the efficacy of rTMS on reducing relapse rates and improving psychosocial functioning. And lastly, we will complete an exploratory aim in which we will obtain pilot data on the ability of fMRI scans to yield biomarkers that will be useful in selecting which Veterans would most benefit from intensive interventions such as rTMS

兴奋剂使用障碍是退伍军人严重残疾和功能障碍的原因。我们 目前还没有有效的躯体疗法来治疗这种情况。这项提案将进行一次 可行性研究，以确定我们管理和完成双盲、假控制的能力 重复经颅刺激(RTMS)治疗兴奋剂使用的随机研究 无序。一半的参与者将被随机分配接受假治疗，而另一半的参与者将被随机分配接受假治疗 一半接受主动rTMS到背外侧前额叶皮质(DLPFC)。我们还将获得飞行员 数据支持rTMS在降低复发率和改善心理社会方面的有效性 功能正常。最后，我们将完成一个探索性目标，在这个目标中，我们将获得关于 功能磁共振成像扫描能够产生生物标志物，这将有助于选择哪些退伍军人最 受益于强化干预措施，如rTMS