Improving Neurocognitive Deficits and Function in Schizophrenia with Transcranial Magnetic Stimulation

通过经颅磁刺激改善精神分裂症的神经认知缺陷和功能

• 批准号: 9350485
• 负责人: JONG H YOON
• 金额: --
• 依托单位: VETERANS ADMIN PALO ALTO HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9350485
• 关键词: Affect; Aftercare; Brain region; Clinical effectiveness; Cognition; Cognitive deficits; Cognitive remediation; Data; Development; Double-Blind Method; Effectiveness; Electroencephalogram; Frequencies; Functional disorder; Generations; Goals; Grant; Health; High Frequency Oscillation; Impairment; Individual; Intervention; Knowledge; Measurement; Measures; Mediating; Mediator of activation protein; Memory impairment; Methods; Modality; Morbidity - disease rate; Neurobiology; Neurocognitive Deficit; Participant; Performance; Placebos; Plant Roots; Population; Prefrontal Cortex; Process; Randomized; Refractory; Research Design; Sampling; Scalp structure; Schizophrenia; Short-Term Memory; Source; System; Task Performances; Testing; Transcranial magnetic stimulation; Treatment Efficacy; Veterans; active method; brain dysfunction; burden of illness; cognitive performance; cognitive process; cost; cost effective; design; disability; effective therapy; efficacy testing; hippocampal pyramidal neuron; improved; magnetic field; neuromechanism; novel therapeutics; predicting response; predictive marker; predictive of treatment response; relating to nervous system; response biomarker; severe mental illness; symptom treatment; theories; treatment response

Cognitive deficits in schizophrenia account for a significant proportion of the disability and dysfunction that this illness confers on Veterans. We currently do not have effective treatments for these symptoms. This proposal will test the efficacy of repetitive transcranial stimulation (rTMS) on treating cognitive deficits in schizophrenia using a randomized double-blind, parallel groups design in which half the participants with schizophrenia will be randomly assigned to receive active rTMS to the dorsolateral prefrontal cortex (DLPFC) and the other half to receive sham rTMS. Comparisons of cognitive performance before and after treatment will determine if rTMS is effective in treating cognitive deficits. In addition to testing rTMS efficacy, we will also determine whether the remediation of cognitive deficits is mediated by improving gamma band oscillation. Gamma oscillations is a electroencephalogram (EEG) measure of the coordinated neural activity underlying cognition. It is that thought a core pathophysiologic mechanism for cognitive deficits in schizophrenia involves impaired gamma oscillations. We will measure frontal gamma levels using EEG before and after rTMS to determine if rTMS remediates gamma deficits and whether it correlates with the magnitude of improvements in cognitive performance with rTMS. The successful completion of this grant will provide important information on the efficacy of a new promising treatment for cognitive deficits in schizophrenia. Furthermore, it will validate EEG gamma measurements as a predictive biomarker of therapeutic response to rTMS.

精神分裂症的认知缺陷占残疾的很大比例， 这种疾病给退伍军人带来的功能障碍。我们目前还没有有效的治疗方法 这些症状。这项建议将测试重复经颅刺激(RTMS)对 随机、双盲、平行分组设计治疗精神分裂症认知障碍 其中一半的精神分裂症参与者将被随机分配接受有效的rTMS 另一半接受假rTMS治疗。 治疗前后认知功能的比较将决定rTMS是否有效 在治疗认知缺陷方面。除了测试rTMS的疗效外，我们还将确定是否 认知缺陷的修复是通过改善伽马频段振荡来实现的。伽马 振荡是对潜在的协调神经活动的脑电(EEG)测量 认知力。它被认为是认知障碍的核心病理生理机制 精神分裂症涉及伽马振荡受损。我们将使用以下工具测量额部伽马水平 在rTMS前后进行脑电检查，以确定rTMS是否补救了伽马缺陷以及是否 与rTMS在认知表现方面的改善程度相关。这个 这笔赠款的成功完成将提供有关新的 有望治疗精神分裂症的认知缺陷。此外，它还将验证脑电 伽玛测量作为rTMS治疗反应的预测生物标志物。