Treating Stimulant Addiction with Repetitive Transcranial Magnetic Stimulation

通过重复经颅磁刺激治疗兴奋剂成瘾

• 批准号: 10013791
• 负责人: JONG H YOON
• 金额: --
• 依托单位: VETERANS ADMIN PALO ALTO HEALTH CARE SYS
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10013791
• 关键词: Abstinence; Adaptive Behaviors; Affective; Aftercare; Amphetamines; Behavioral; Biological Markers; Brain; Brain region; Clinical; Cocaine; Cognitive; Controlled Study; Data; Development; Disease; Dopamine; Double-Blind Method; FDA approved; Feasibility Studies; Frequencies; Functional Magnetic Resonance Imaging; Functional disorder; Health; Homelessness; Intervention; Left; Legal; Major Depressive Disorder; Measures; Methods; Morbidity - disease rate; Occupational; Participant; Patient Selection; Personal Satisfaction; Pharmaceutical Preparations; Placebos; Prediction of Response to Therapy; Prefrontal Cortex; Process; Property; Psychopathology; Psychostimulant dependence; Randomized; Refractory; Relapse; Research Design; Rewards; Role; Services; Signal Transduction; Suicide; Toxicology; Urine; Veterans; adaptive learning; addiction; base; cost effective; design; disability; drug of abuse; functional MRI scan; functional status; improved; magnetic field; methamphetamine use; neuropsychiatry; psychosocial; randomized controlled study; relapse prediction; relating to nervous system; repetitive transcranial magnetic stimulation; reward processing; sham-controlled study; social deficits; stimulant use; stimulant use disorder; treatment comparison; treatment group

Stimulant use disorder accounts for significant disability and dysfunction among Veterans. We currently do not have effective somatic treatments for this condition. This proposal will conduct a feasibility study to determine our ability to administer and complete a double-blind, sham-controlled randomized study using repetitive transcranial stimulation (rTMS) for treating stimulant use disorder. Half of the participants will be randomly assigned to receive sham treatment and the other half to receive active rTMS to the dorsolateral prefrontal cortex (DLPFC). We will also obtain pilot data supporting the efficacy of rTMS on reducing relapse rates and improving psychosocial functioning. And lastly, we will complete an exploratory aim in which we will obtain pilot data on the ability of fMRI scans to yield biomarkers that will be useful in selecting which Veterans would most benefit from intensive interventions such as rTMS

兴奋剂使用障碍在退伍军人中占重要的残疾和功能障碍。我们