Multidisciplinary Approaches to Tumor Immunology

项目总结/摘要 罗斯威尔公园癌症研究所肿瘤免疫学培训计划（TITP）的总体目标 （RPCI）研究生部是教育，培训和准备有才华的博士前学生的职业， 癌症免疫学研究。在理解免疫系统如何 作为对抗癌症的武器，肿瘤免疫学的未来领导者不仅要在 学科，但也将有潜在的翻译对人类癌症生物学的影响强烈赞赏 和心理治疗TITP内独特的癌症焦点向学员介绍了先进的教学和 概念性癌症免疫学教育范式，涵盖了跨越以下连续体的知识 从基础科学到临床应用。该TITP的独特性通过集成 学术环境由不同的教师集中在一个著名的NCI指定 综合癌症中心。学员接触到一个全面的组合与癌症有关的主题 这将通过2018年秋季开始的新的“总括”学术课程得到加强。正是在 第一年的学习时，学员将选择肿瘤免疫学特异性的“轨道”，然后进行他们的 博士研究与TITP教师在基础，转化或临床科学的专业知识。主 培训补助金更新的使命是支持竞争性选择的学生在他们的第三和第四 多年的研究。申请的资金包括每年4名博士预科生的津贴和学费。这 资金是至关重要的继续上升轨迹经历了近15年的NRSA的支持， 质量和博士前学员的多样性集中在复杂和具有挑战性的免疫学问题， 癌NRSA支持的学员通过教学讲座为竞争性的生物医学职业做好准备 以及肿瘤免疫学和生物学的概念驱动学习，资助写作和研究的道德行为。 完成所有正式课程后，学位授予取决于通过初步考试， 满足第一作者的出版要求，并通过论文答辩反映小说和 学生的工作的原始发现。完成本TITP的学员将精通所有专业 肿瘤免疫学的各个方面，并将有坚实的基础上建立癌症为重点的职业生涯， 它对人类癌症生物学和治疗的影响有着清晰的愿景。

PROJECT SUMMARY/ABSTRACT The overarching goals of the Tumor Immunology Training Program (TITP) at the Roswell Park Cancer Institute (RPCI) Graduate Division are to educate, train and prepare talented pre-doctoral students for a profession in cancer immunology research. Driven by significant advances in understanding how the immune system can be weaponized against cancer, future leaders in tumor immunology will not only be well-trained in the discipline, but also will have a strong appreciation of the potential translational impact to human cancer biology and therapy. The unique, cancer-focus within the TITP introduces trainees to an advanced didactic and conceptual cancer immunology educational paradigm that encapsulates knowledge spanning the continuum of basic science to clinical application. The uniqueness of this TITP is further enhanced by the integration of an academic environment comprised of diverse faculty concentrated within a prestigious NCI-designated Comprehensive Cancer Center. Trainees are exposed to a comprehensive portfolio of cancer-related topics that will be enhanced through a new “umbrella” academic curriculum starting in the fall of 2018. It is during the first year of study when trainees will select the tumor immunology-specific “track” and then conduct their doctoral research with TITP faculty with expertise in basic, translational, or clinical sciences. The primary mission of the training grant renewal is to support competitively selected students during their third and fourth years of study. The funds requested cover stipends and tuition for 4 pre-doctoral students per year. This funding is crucial to continue the upward trajectory experienced for nearly 15 years of NRSA support in the quality and diversity of pre-doctoral trainees focused on complex and challenging immunologic questions in cancer. NRSA-supported trainees are prepared for a competitive biomedical career through didactic lectures and concept-driven learning in tumor immunology and biology, grant writing and ethical conduct of research. After completing all formal course work, degree conferral is dependent upon passing the preliminary exam, fulfilling a first-authored publication requirement, and passing the dissertation defense reflecting the novel and original findings of the student's body-of-work. Trainees who complete this TITP will be well-versed in all major facets of tumor immunology and will have the solid foundation upon which to build cancer-focused careers, guided by a clear vision of its impact on human cancer biology and treatment.