Multidisciplinary Approaches to Tumor Immunology

肿瘤免疫学的多学科方法

• 批准号: 10472619
• 负责人: Scott I. Abrams
• 金额: $ 15.13万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10472619
• 关键词: interdisciplinary approach; tumor immunology

PROJECT SUMMARY/ABSTRACT The overarching goals of the Tumor Immunology Training Program (TITP) at the Roswell Park Cancer Institute (RPCI) Graduate Division are to educate, train and prepare talented pre-doctoral students for a profession in cancer immunology research. Driven by significant advances in understanding how the immune system can be weaponized against cancer, future leaders in tumor immunology will not only be well-trained in the discipline, but also will have a strong appreciation of the potential translational impact to human cancer biology and therapy. The unique, cancer-focus within the TITP introduces trainees to an advanced didactic and conceptual cancer immunology educational paradigm that encapsulates knowledge spanning the continuum of basic science to clinical application. The uniqueness of this TITP is further enhanced by the integration of an academic environment comprised of diverse faculty concentrated within a prestigious NCI-designated Comprehensive Cancer Center. Trainees are exposed to a comprehensive portfolio of cancer-related topics that will be enhanced through a new “umbrella” academic curriculum starting in the fall of 2018. It is during the first year of study when trainees will select the tumor immunology-specific “track” and then conduct their doctoral research with TITP faculty with expertise in basic, translational, or clinical sciences. The primary mission of the training grant renewal is to support competitively selected students during their third and fourth years of study. The funds requested cover stipends and tuition for 4 pre-doctoral students per year. This funding is crucial to continue the upward trajectory experienced for nearly 15 years of NRSA support in the quality and diversity of pre-doctoral trainees focused on complex and challenging immunologic questions in cancer. NRSA-supported trainees are prepared for a competitive biomedical career through didactic lectures and concept-driven learning in tumor immunology and biology, grant writing and ethical conduct of research. After completing all formal course work, degree conferral is dependent upon passing the preliminary exam, fulfilling a first-authored publication requirement, and passing the dissertation defense reflecting the novel and original findings of the student's body-of-work. Trainees who complete this TITP will be well-versed in all major facets of tumor immunology and will have the solid foundation upon which to build cancer-focused careers, guided by a clear vision of its impact on human cancer biology and treatment.

项目概要/摘要 罗斯威尔帕克癌症研究所肿瘤免疫学培训计划 (TITP) 的总体目标 (RPCI) 研究生部负责教育、培训和准备有才华的博士前学生，以从事以下领域的职业： 癌症免疫学研究。在了解免疫系统如何发挥作用方面取得重大进展的推动下 成为对抗癌症的武器，肿瘤免疫学的未来领导者将不仅在以下领域接受过良好的培训 学科，但也会对人类癌症生物学的潜在转化影响有强烈的认识 和治疗。 TITP 中独特的癌症重点向学员介绍了先进的教学和 概念性癌症免疫学教育范式，囊括了跨越连续体的知识 基础科学到临床应用。该 TITP 的独特性通过集成 学术环境由不同的教师组成，集中在著名的 NCI 指定的大学中 综合癌症中心。学员将接触到全面的癌症相关主题 这将通过 2018 年秋季开始的新“伞”学术课程得到加强。 第一年的学习，学员将选择肿瘤免疫学特异性“轨道”，然后进行他们的研究 与具有基础科学、转化科学或临床科学专业知识的 TITP 教师一起进行博士研究。初级 更新培训补助金的使命是支持竞争性选拔的学生在第三和第四年的学习 多年的学习。申请的资金用于支付每年 4 名博士前学生的津贴和学费。这 资金对于继续保持 NRSA 在近 15 年来的支持中所经历的上升轨迹至关重要。 博士前学员的质量和多样性，重点关注复杂和具有挑战性的免疫学问题 癌症。 NRSA 支持的学员通过教学讲座为竞争激烈的生物医学职业做好准备 肿瘤免疫学和生物学、资助写作和研究道德行为方面的概念驱动学习。 完成所有正式课程后，学位授予取决于通过初步考试， 满足第一作者发表要求，并通过反映小说和内容的论文答辩 学生作品的原始发现。完成此 TITP 的学员将精通所有专业 肿瘤免疫学的各个方面，并将为建立以癌症为重点的职业奠定坚实的基础， 以其对人类癌症生物学和治疗的影响的清晰愿景为指导。