Multidisciplinary Approaches to Tumor Immunology

项目摘要/摘要 罗斯威尔公园癌症研究所肿瘤免疫学培训计划(TITP)的总体目标 (RPCI)研究生部是教育、培训和准备有才华的博士后学生在 癌症免疫学研究。在理解免疫系统如何能够 作为对抗癌症的武器，未来的肿瘤免疫学领导者不仅将在 学科，但也将强烈认识到对人类癌症生物学的潜在翻译影响 和心理治疗。TITP中独特的癌症焦点向学员介绍了高级教学和 概念性癌症免疫学教育范例，概括了横跨 从基础科学到临床应用。该TITP的独特性通过整合 学术环境由不同的教员组成，集中在著名的NCI指定的 综合癌症中心。学员将接触到一系列与癌症相关的综合话题。 这一点将通过从2018年秋季开始的新的“保护伞”学术课程得到加强。这是在 第一年的学习时间，受训者将选择肿瘤免疫学特定的“轨道”，然后进行他们的 与TITP教授进行博士研究，具有基础、翻译或临床科学方面的专业知识。初级阶段 培训补助金续期的任务是在第三和第四阶段支持竞争性选拔的学生 多年的学习。申请的资金包括每年4名博士前学生的津贴和学费。这 资金对于延续近15年的NRSA支持的上升轨迹至关重要 博士前培训人员的质量和多样性侧重于复杂和具有挑战性的免疫学问题 癌症。NRSA支持的实习生通过授课为竞争激烈的生物医学职业生涯做好准备 以及肿瘤免疫学和生物学方面的概念驱动型学习、拨款撰写和研究的伦理行为。 完成所有正式课程作业后，学位授予取决于通过初试， 满足第一作者发表的要求，并通过反映小说和 学生工作机构的原始调查结果。完成此TITP课程的学员将精通所有专业 肿瘤免疫学的各个方面，并将拥有坚实的基础，在此基础上建立以癌症为重点的职业生涯， 以对其对人类癌症生物学和治疗的影响的明确愿景为指导。

PROJECT SUMMARY/ABSTRACT The overarching goals of the Tumor Immunology Training Program (TITP) at the Roswell Park Cancer Institute (RPCI) Graduate Division are to educate, train and prepare talented pre-doctoral students for a profession in cancer immunology research. Driven by significant advances in understanding how the immune system can be weaponized against cancer, future leaders in tumor immunology will not only be well-trained in the discipline, but also will have a strong appreciation of the potential translational impact to human cancer biology and therapy. The unique, cancer-focus within the TITP introduces trainees to an advanced didactic and conceptual cancer immunology educational paradigm that encapsulates knowledge spanning the continuum of basic science to clinical application. The uniqueness of this TITP is further enhanced by the integration of an academic environment comprised of diverse faculty concentrated within a prestigious NCI-designated Comprehensive Cancer Center. Trainees are exposed to a comprehensive portfolio of cancer-related topics that will be enhanced through a new “umbrella” academic curriculum starting in the fall of 2018. It is during the first year of study when trainees will select the tumor immunology-specific “track” and then conduct their doctoral research with TITP faculty with expertise in basic, translational, or clinical sciences. The primary mission of the training grant renewal is to support competitively selected students during their third and fourth years of study. The funds requested cover stipends and tuition for 4 pre-doctoral students per year. This funding is crucial to continue the upward trajectory experienced for nearly 15 years of NRSA support in the quality and diversity of pre-doctoral trainees focused on complex and challenging immunologic questions in cancer. NRSA-supported trainees are prepared for a competitive biomedical career through didactic lectures and concept-driven learning in tumor immunology and biology, grant writing and ethical conduct of research. After completing all formal course work, degree conferral is dependent upon passing the preliminary exam, fulfilling a first-authored publication requirement, and passing the dissertation defense reflecting the novel and original findings of the student's body-of-work. Trainees who complete this TITP will be well-versed in all major facets of tumor immunology and will have the solid foundation upon which to build cancer-focused careers, guided by a clear vision of its impact on human cancer biology and treatment.