Multidisciplinary Approaches to Tumor Immunology
肿瘤免疫学的多学科方法
基本信息
- 批准号:10248383
- 负责人:
- 金额:$ 13.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-09-01 至 2023-08-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
PROJECT SUMMARY/ABSTRACT
The overarching goals of the Tumor Immunology Training Program (TITP) at the Roswell Park Cancer Institute
(RPCI) Graduate Division are to educate, train and prepare talented pre-doctoral students for a profession in
cancer immunology research. Driven by significant advances in understanding how the immune system can
be weaponized against cancer, future leaders in tumor immunology will not only be well-trained in the
discipline, but also will have a strong appreciation of the potential translational impact to human cancer biology
and therapy. The unique, cancer-focus within the TITP introduces trainees to an advanced didactic and
conceptual cancer immunology educational paradigm that encapsulates knowledge spanning the continuum of
basic science to clinical application. The uniqueness of this TITP is further enhanced by the integration of an
academic environment comprised of diverse faculty concentrated within a prestigious NCI-designated
Comprehensive Cancer Center. Trainees are exposed to a comprehensive portfolio of cancer-related topics
that will be enhanced through a new “umbrella” academic curriculum starting in the fall of 2018. It is during the
first year of study when trainees will select the tumor immunology-specific “track” and then conduct their
doctoral research with TITP faculty with expertise in basic, translational, or clinical sciences. The primary
mission of the training grant renewal is to support competitively selected students during their third and fourth
years of study. The funds requested cover stipends and tuition for 4 pre-doctoral students per year. This
funding is crucial to continue the upward trajectory experienced for nearly 15 years of NRSA support in the
quality and diversity of pre-doctoral trainees focused on complex and challenging immunologic questions in
cancer. NRSA-supported trainees are prepared for a competitive biomedical career through didactic lectures
and concept-driven learning in tumor immunology and biology, grant writing and ethical conduct of research.
After completing all formal course work, degree conferral is dependent upon passing the preliminary exam,
fulfilling a first-authored publication requirement, and passing the dissertation defense reflecting the novel and
original findings of the student's body-of-work. Trainees who complete this TITP will be well-versed in all major
facets of tumor immunology and will have the solid foundation upon which to build cancer-focused careers,
guided by a clear vision of its impact on human cancer biology and treatment.
项目概要/摘要
罗斯威尔帕克癌症研究所肿瘤免疫学培训计划 (TITP) 的总体目标
(RPCI) 研究生部负责教育、培训和准备有才华的博士前学生,以从事以下领域的职业:
癌症免疫学研究。在了解免疫系统如何发挥作用方面取得重大进展的推动下
成为对抗癌症的武器,肿瘤免疫学的未来领导者将不仅在以下领域接受过良好的培训
学科,但也会对人类癌症生物学的潜在转化影响有强烈的认识
和治疗。 TITP 中独特的癌症重点向学员介绍了先进的教学和
概念性癌症免疫学教育范式,囊括了跨越连续体的知识
基础科学到临床应用。该 TITP 的独特性通过集成
学术环境由不同的教师组成,集中在著名的 NCI 指定的大学中
综合癌症中心。学员将接触到全面的癌症相关主题
这将通过 2018 年秋季开始的新“伞”学术课程得到加强。
第一年的学习,学员将选择肿瘤免疫学特异性“轨道”,然后进行他们的研究
与具有基础科学、转化科学或临床科学专业知识的 TITP 教师一起进行博士研究。初级
更新培训补助金的使命是支持竞争性选拔的学生在第三和第四年的学习
多年的学习。申请的资金用于支付每年 4 名博士前学生的津贴和学费。这
资金对于继续保持 NRSA 在近 15 年来的支持中所经历的上升轨迹至关重要。
博士前学员的质量和多样性,重点关注复杂和具有挑战性的免疫学问题
癌症。 NRSA 支持的学员通过教学讲座为竞争激烈的生物医学职业做好准备
肿瘤免疫学和生物学、资助写作和研究道德行为方面的概念驱动学习。
完成所有正式课程后,学位授予取决于通过初步考试,
满足第一作者发表要求,并通过反映小说和内容的论文答辩
学生作品的原始发现。完成此 TITP 的学员将精通所有专业
肿瘤免疫学的各个方面,并将为建立以癌症为重点的职业奠定坚实的基础,
以其对人类癌症生物学和治疗的影响的清晰愿景为指导。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Scott I. Abrams其他文献
Differences in Immune Cell Populations between Individuals with or without MGUS
- DOI:
10.1182/blood-2024-206171 - 发表时间:
2024-11-05 - 期刊:
- 影响因子:
- 作者:
Sawyer Bawek;Janine M. Joseph;Alan Hutson;Sarah Parker;Joseph D. Tario Jr;Hamza Hassan;Scott I. Abrams;Jens Hillengass - 通讯作者:
Jens Hillengass
Influence of interferon γ on modulation of Fas expression by human colon carcinoma cells and their subsequent sensitivity to antigen-specific CD8+ cytotoxic T lymphocyte attack
- DOI:
10.1007/s002620000105 - 发表时间:
2000-06-01 - 期刊:
- 影响因子:5.100
- 作者:
Elke S. Bergmann-Leitner;Scott I. Abrams - 通讯作者:
Scott I. Abrams
Immune response to a carcinoembryonic antigen polynucleotide vaccine.
对癌胚抗原多核苷酸疫苗的免疫反应。
- DOI:
- 发表时间:
1994 - 期刊:
- 影响因子:11.2
- 作者:
R. Conry;A. Lobuglio;Judy Kantor;Jeffrey Schlom;F. Loechel;S. Moore;L. Sumerel;D. L. Barlow;Scott I. Abrams;David T. Curici - 通讯作者:
David T. Curici
Immune Markers of Multiple Myeloma Patients Demonstrate Significant Change after Participation in Six-Month Physical Activity Intervention
- DOI:
10.1182/blood-2022-167655 - 发表时间:
2022-11-15 - 期刊:
- 影响因子:
- 作者:
Janine M. Joseph;Michaela Hillengass;Hillary Jacobson;Joseph D. Tario;Kristopher Attwood;Adrienne Groman;Rikki Cannioto;Bryan Wittmeyer;Kirsten Moysich;Scott I. Abrams;Jens Hillengass - 通讯作者:
Jens Hillengass
Induction of antitumor immunity by recombinant vaccinia viruses expressing B7-1 or B7-2 costimulatory molecules.
通过表达 B7-1 或 B7-2 共刺激分子的重组痘苗病毒诱导抗肿瘤免疫。
- DOI:
- 发表时间:
1994 - 期刊:
- 影响因子:11.2
- 作者:
J. Hodge;Scott I. Abrams;J. Schlom;Judy Kantor - 通讯作者:
Judy Kantor
Scott I. Abrams的其他文献
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{{ truncateString('Scott I. Abrams', 18)}}的其他基金
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
循环骨髓细胞簇对抗肿瘤免疫的影响
- 批准号:
10322156 - 财政年份:2021
- 资助金额:
$ 13.55万 - 项目类别:
Development of a Novel Immunotherapy Platform for Triple-Negative Breast Cancer
开发针对三阴性乳腺癌的新型免疫治疗平台
- 批准号:
10463811 - 财政年份:2021
- 资助金额:
$ 13.55万 - 项目类别:
Development of a Novel Immunotherapy Platform for Triple-Negative Breast Cancer
开发针对三阴性乳腺癌的新型免疫治疗平台
- 批准号:
10287834 - 财政年份:2021
- 资助金额:
$ 13.55万 - 项目类别:
Impact of Circulating Myeloid Cell Clusters on Anti-Tumor Immunity
循环骨髓细胞簇对抗肿瘤免疫的影响
- 批准号:
10543820 - 财政年份:2021
- 资助金额:
$ 13.55万 - 项目类别:
Tumor Immune Contexture and Breast Cancer Disparities: A Multi-Disciplinary Study in Women of African and European Ancestry
肿瘤免疫环境和乳腺癌差异:针对非洲和欧洲血统女性的多学科研究
- 批准号:
10653186 - 财政年份:2020
- 资助金额:
$ 13.55万 - 项目类别:
Tumor Immune Contexture and Breast Cancer Disparities: A Multi-Disciplinary Study in Women of African and European Ancestry
肿瘤免疫环境和乳腺癌差异:针对非洲和欧洲血统女性的多学科研究
- 批准号:
10171569 - 财政年份:2020
- 资助金额:
$ 13.55万 - 项目类别:
Tumor Immune Contexture and Breast Cancer Disparities: A Multi-Disciplinary Study in Women of African and European Ancestry
肿瘤免疫环境和乳腺癌差异:针对非洲和欧洲血统女性的多学科研究
- 批准号:
10404988 - 财政年份:2020
- 资助金额:
$ 13.55万 - 项目类别:
A Cobalt Porphyrin Nanoliposome Adjuvant for MHC-I-Restricted Cancer Peptide Vaccines
用于 MHC-I 限制性癌症肽疫苗的钴卟啉纳米脂质体佐剂
- 批准号:
10320831 - 财政年份:2020
- 资助金额:
$ 13.55万 - 项目类别:
A Cobalt Porphyrin Nanoliposome Adjuvant for MHC-I-Restricted Cancer Peptide Vaccines
用于 MHC-I 限制性癌症肽疫苗的钴卟啉纳米脂质体佐剂
- 批准号:
10557071 - 财政年份:2020
- 资助金额:
$ 13.55万 - 项目类别:
Multidisciplinary Approaches to Tumor Immunology
肿瘤免疫学的多学科方法
- 批准号:
10472619 - 财政年份:2019
- 资助金额:
$ 13.55万 - 项目类别:
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