Multidisciplinary Approaches to Tumor Immunology

项目摘要/摘要 罗斯威尔公园综合体肿瘤免疫学培训计划(TITP)的总体目标 癌症中心研究生部将教育、培训和准备有才华的博士前实习生 从事癌症免疫学研究。在理解免疫如何产生的重大进展的推动下 系统可以武器化对抗癌症，未来肿瘤免疫学的领军人物不仅将在 这门学科，也将强烈地认识到潜在的翻译对人类癌症的影响 生物学和治疗学。TITP独特的癌症焦点向学员介绍了先进的教学和 概念性癌症免疫学教育范例，概括了横跨 从基础科学到临床应用。该TITP的独特性通过整合 学术环境由不同的教员组成，集中在著名的NCI指定的 综合癌症中心。在整个计划中，实习生不断地接触到 全面的肿瘤免疫学主题和概念组合，负责任的研究工作，以及 严谨和可重复性的原则。受训者在TITP导师的指导下进行博士研究 在基础、翻译和临床肿瘤免疫学方面的专业知识。TITP的主要使命是支持 在第三年和第四年的学习中被竞争性挑选的受训人员。申请的资金包括 每年为4名博士前实习生提供津贴和学费。这笔资金对继续上行至关重要 近20年来NRSA在博士前学员质量和多样性方面的支持轨迹 专注于癌症中复杂和具有挑战性的免疫学问题。NRSA支持的学员有 通过肿瘤的教学讲座和概念驱动的学习为竞争激烈的生物医学职业生涯做好准备 免疫学和生物学，拨款撰写，负责任的研究行为，以及严密性和重复性。之后 学员完成所有正式课程并通过资格考试，学位授予取决于 满足第一作者的出版要求，并通过反映小说和 实习生工作机构的原始调查结果。完成此TITP课程的学员将精通所有专业 肿瘤免疫学的各个方面，并将拥有坚实的基础，在此基础上建立以癌症为重点的职业生涯， 以对其对人类癌症生物学和治疗的影响的明确愿景为指导。

PROJECT SUMMARY/ABSTRACT The overarching goals of the Tumor Immunology Training Program (TITP) at Roswell Park Comprehensive Cancer Center Graduate Division are to educate, train, and prepare talented pre-doctoral trainees for a profession in cancer immunology research. Driven by significant advances in understanding how the immune system can be weaponized against cancer, future leaders in tumor immunology will not only be well-trained in the discipline, but also will have a strong appreciation of the potential translational impact to human cancer biology and therapy. The unique, cancer-focus of the TITP introduces trainees to an advanced didactic and conceptual cancer immunology educational paradigm that encapsulates knowledge spanning the continuum of basic science to clinical application. The uniqueness of this TITP is further enhanced by the integration of an academic environment comprised of diverse faculty concentrated within a prestigious NCI-designated Comprehensive Cancer Center. Throughout the program, trainees are continually exposed to a comprehensive portfolio of themes and concepts in tumor immunology, responsible conduct of research, and the principles of rigor and reproducibility. Trainees conduct their doctoral research with TITP mentors with expertise in basic, translational, and clinical tumor immunology. The primary mission of the TITP is to support competitively selected trainees during their third and fourth years of study. The funds requested cover stipends and tuition for 4 pre-doctoral trainees per year. This funding is crucial to continue the upward trajectory experienced for nearly 20 years of NRSA support in the quality and diversity of pre-doctoral trainees focused on complex and challenging immunologic questions in cancer. NRSA-supported trainees are prepared for a competitive biomedical career through didactic lectures and concept-driven learning in tumor immunology and biology, grant writing, responsible conduct of research, and rigor and reproducibility. After trainees complete all formal course work and pass a qualifying exam, degree conferral is dependent upon fulfilling a first-authored publication requirement and passing the dissertation defense reflecting the novel and original findings of the trainee’s body-of-work. Trainees who complete this TITP will be well-versed in all major facets of tumor immunology and will have the solid foundation upon which to build cancer-focused careers, guided by a clear vision of its impact on human cancer biology and treatment.