ECHO IDeA States Pediatric Clinical Trials Network - 2

摘要 达特茅斯是一个强大的儿科学术项目的所在地，该项目以儿童医院为中心， 达特茅斯。在ECHO资助的前三年，我们建立了一个功能强大的 儿科临床试验部门，并将其与达特茅斯内的临床试验资源整合 ECHO IDEA国家儿科临床试验网络（ISPCTN）。这使得 我们支持和扩大儿科临床试验组合，招募研究人员和团体， 核心，利用现有资源，开发新资源，吸引当地和多中心参与， 临床试验，并促进广泛的专业发展。我们的调查小组 实质上是对ISPCTN的开发、领导、协议设计和实施的贡献。 以达特茅斯地区儿科临床的形式组织我们的地区存在 试验单位（DRP-CTU）将允许招募多样化的儿科人群，包括那些 农村和服务不足。展望未来，我们建议在现有基础设施的基础上， 临床试验实施和专业发展。 为此，我们提出三个具体目标： 1.发展针对孕妇和儿童的机构临床研究能力 特别强调农村和得不到充分服务的人口。 2.促进教师的专业发展和支持团队成员在 进行转化临床研究。 3.为了激励和支持我们的儿科研究社区进行多中心研究， 儿科条件和疾病过程。 我们还提出了一项主题性的、有影响力的临床试验来评估青少年电子烟戒烟策略， 由该领域的思想领袖指导。 这一举措将提供一个急需的中央协调平台， 达特茅斯社区的临床试验。它将为ISPCTN的各个方面做出贡献，并将 支持现有和新的研究者-扩大我们的临床试验范围，刺激扩张 我们的投资组合，并提供新的专业发展机会， 招聘/培训新的教师和研究人员。

ABSTRACT Dartmouth is home to a robust pediatric academic program centered in the Children’s Hospital at Dartmouth (CHaD). During the first three years of ECHO funding, we have built a highly functioning pediatric Clinical Trials Unit and integrated it with clinical trials resources within the Dartmouth community and the ECHO IDeA States Pediatric Clinical Trials Network (ISPCTN). This has allowed us to support and expand the pediatric clinical trials portfolio, to recruit investigators and groups to this core, to leverage existing resources and develop new ones, to engage local as well as multi-center clinical trials, and to foster broad professional development. Our investigative team has contributed substantially to the development, leadership, and protocol design and implementation of the ISPCTN. The organization of our regional presence in the form of the Dartmouth Regional Pediatric Clinical Trials Unit (DRP-CTU) will allow recruitment of a diverse pediatric population, including those who are rural and underserved. Going forward, we propose to build on our existing infrastructure in support of clinical trial implementation and professional development. To accomplish this, we propose three Specific AIMS: 1. To develop institutional clinical research capacity targeting pregnant women and children with a special emphasis on rural and underserved populations. 2. To foster the professional development of faculty and support team members in the conduct of translational clinical research. 3. To stimulate and support our pediatric research community in the multicenter study of pediatric conditions and disease processes. We also propose a topical, impactful clinical trial to evaluate Youth Vaping Cessation Strategies, directed by thought leaders in this field. This initiative will provide a much-needed central coordinating platform for the conduct of pediatric clinical trials in the Dartmouth community. It will contribute to all aspects of the ISPCTN and will support existing and new investigators - expanding our clinical trials universe, stimulating expansion of our portfolio, and offering new opportunities for professional development with the resultant recruitment/training of new faculty and research staff.