Stereoselective Nickel-Catalyzed Coupling and Cascade Reactions

立体选择性镍催化偶联和级联反应

• 批准号: 10477929
• 负责人: Elizabeth Reinhardt Jarvo
• 金额: $ 29.39万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10477929
• 关键词: Address; Alcohols; Alkanesulfonates; Biological; Chemicals; Chemistry; Clinical Trials; Coupling; Cyclohexanes; Cycloparaffins; Cyclopentane; Development; Ethers; Event; Glycols; In Situ; Intercept; Interruption; Iodides; Knowledge; Mesylates; Methods; Natural Products; Nickel; Organic Synthesis; Organometallic Chemistry; Pharmacologic Substance; Positioning Attribute; Preparation; Production; Reaction; Series; Sulfonamides; Synthesis Chemistry; System; Testing; Therapeutic; Transition Elements; base; catalyst; chemical reaction; cyclopropane; design; experimental study; functional group; stereochemistry

Project Summary/Abstract This proposal outlines the development of new chemical methods for cross-coupling reactions for formation of strained rings and in domino reactions. The objectives of this project are to generate new strategies for stereoselective coupling reactions, including stereospecific and stereoconvergent reactions. Reactions will be triggered such that typically sluggish functional groups, including alkyl alcohol derivatives, will participate. The development of these reactions will directly impact the development of new pharmaceutical agents by providing new strategies for their preparation.

项目摘要/摘要 这项建议概述了交叉偶联的新化学方法的发展。 应变环形成的反应和多米诺骨牌反应。这样做的目的是 该项目旨在为立体选择性偶联反应产生新的战略，包括 立体特异性反应和立体收敛反应。反应将被触发，以便 通常缓慢的官能团，包括烷基醇衍生物，将参与其中。 这些反应的发展将直接影响新技术的发展 通过为药物制剂提供新的战略，为药物制剂提供新的战略。