Stereoselective Nickel-Catalyzed Coupling and Cascade Reactions

项目概要/摘要 该提案概述了交叉偶联的新化学方法的发展 形成应变环的反应和多米诺反应。这一目标 项目是产生立体选择性偶联反应的新策略，包括 立体定向和立体会聚反应。反应将被触发， 通常惰性官能团（包括烷基醇衍生物）将参与。 这些反应的发展将直接影响新的发展。 通过提供用于其制备的新策略来制备药物制剂。

Project Summary/Abstract This proposal outlines the development of new chemical methods for cross-coupling reactions for formation of strained rings and in domino reactions. The objectives of this project are to generate new strategies for stereoselective coupling reactions, including stereospecific and stereoconvergent reactions. Reactions will be triggered such that typically sluggish functional groups, including alkyl alcohol derivatives, will participate. The development of these reactions will directly impact the development of new pharmaceutical agents by providing new strategies for their preparation.