Stereoselective Nickel-Catalyzed Coupling and Cascade Reactions

立体选择性镍催化偶联和级联反应

• 批准号: 10052499
• 负责人: Elizabeth Reinhardt Jarvo
• 金额: $ 29.55万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10052499
• 关键词: Address; Alcohols; Alkanesulfonates; Biological; Chemicals; Chemistry; Clinical Trials; Coupling; Cyclohexanes; Cycloparaffins; Cyclopentane; Development; Ethers; Event; Glycols; In Situ; Intercept; Interruption; Iodides; Knowledge; Mesylates; Methods; Natural Products; Nickel; Organic Synthesis; Organometallic Chemistry; Pharmacologic Substance; Positioning Attribute; Preparation; Production; Reaction; Series; Sulfonamides; Synthesis Chemistry; System; Testing; Therapeutic; Transition Elements; base; catalyst; chemical reaction; cyclopropane; design; experimental study; functional group; stereochemistry

Project Summary/Abstract This proposal outlines the development of new chemical methods for cross-coupling reactions for formation of strained rings and in domino reactions. The objectives of this project are to generate new strategies for stereoselective coupling reactions, including stereospecific and stereoconvergent reactions. Reactions will be triggered such that typically sluggish functional groups, including alkyl alcohol derivatives, will participate. The development of these reactions will directly impact the development of new pharmaceutical agents by providing new strategies for their preparation.

项目摘要/摘要 该提案概述了开发用于交叉耦合的新化学方法 形成紧张环和多米诺反应的反应。目标的目标 项目将为立体选择耦合反应生成新的策略，包括 立体特异性和立体的反应。反应将被触发，使得 通常，包括烷基酒精衍生物在内的功能组缓慢。 这些反应的发展将直接影响新的发展 药物通过提供新策略的准备。