Methodology Core

抽象-方法论核心 全关节置换术(TJA)的临床研究需要最高标准的研究设计 利用现有数据源，采用标准化定义和新的临床研究 方法论。TJA研究人员需要得到良好的培训和支持，才能有效应对 TJA目前和正在出现的研究空白。梅奥全关节临床研究核心中心 关节成形术(CORE-TJA)方法学核心将建立在梅奥现有方法学资源的基础上，以 通过提供高质量的咨询，推动国家层面的TJA临床研究的科学化， 教育和指导服务，以及最先进和新颖的方法资源，促进最佳 利用现有的独立或链接的数据库和临床研究网络，培训下一代 TJA临床研究人员和建立科学合作。CORE-TJA的具体目标 方法核心是：(1)通过提供咨询，加强国家层面的TJA临床研究， 为TJA调查人员提供教育和指导服务，(2)利用现有数据库和临床 为TJA临床确定信息量最大的研究人群和研究设计的研究网络 研究，以及(3)开发和传播适用于观测和研究的新方法 TJA临床研究中的干预研究设计。具体地说，方法论核心将侧重于6 TJA研究中的具体方法论领域：TJA研究中解释偏差和混淆的方法， 应用TJA特定的信息学工具从电子健康记录中自动提取数据， 患者报告的结果研究，嵌入登记和/或医疗系统的临床试验，混合- 方法研究和实施研究。CORE-TJA方法核心将创建一个灵活的、 可持续的研究基础设施、训练有素的劳动力和国家一级的协同合作。

ABSTRACT - METHODOLOGY CORE Clinical research in total joint arthroplasty (TJA) demands the highest standards of study design while leveraging existing data sources and adopting standardized definitions and novel clinical research methodologies. TJA researchers need to be well-trained and supported if they are to respond effectively to current and emerging research gaps in TJA. The Mayo Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) Methodology Core will build upon Mayo’s existing methodology resources to advance the science of TJA clinical research at the national level by providing high-quality consulting, education and mentoring services, and state-of-the-art and novel methodology resources, facilitating optimal use of existing stand-alone or linked databases and clinical research networks, training of the next generation of TJA clinical investigators and building scientific collaborations. The Specific Aims of the CORE-TJA Methodology Core are: (1) To enhance TJA clinical research at the national level by providing consultation, education and mentoring services for TJA investigators, (2) To leverage existing databases and clinical research networks to identify the most informative study populations and study designs for TJA clinical research, and (3) To develop and disseminate novel methodologies applicable to observational and interventional study designs in TJA clinical research. Specifically, the Methodology Core will focus on 6 specific methodological areas in TJA research: methods to account for bias and confounding in TJA research, application of TJA-specific informatics tools for automated data extraction from the electronic health records, patient-reported outcomes research, clinical trials embedded in registries and/or healthcare systems, mixed- methods research and implementation research. The CORE-TJA Methodology Core will create a flexible, sustainable research infrastructure, trained workforce and synergistic collaborations at the national level.