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Methodology Core

方法论核心

基本信息

批准号：
10703442
负责人：
Hilal Maradit Kremers
金额：
$ 49.69万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-09-16 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10703442
关键词：
Address Adopted American American College of Surgeons Area Caring Clinic Clinical Data Clinical Investigator Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Consultations Data Data Set Data Sources Databases Dissemination and Implementation E-learning Education Effectiveness Electronic Health Record Ensure Epidemiology Evidence based practice Future Goals Health Health Care Costs Health Services Research Healthcare Systems Hospitals Human Resources Improve Access Informatics Infrastructure Intervention Studies Joints Learning Module Link Medicare claim Mentors Methodology Methods Midwestern United States National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Observational Study Online Systems Operative Surgical Procedures Outcome Outcomes Research Patient Outcomes Assessments Periprosthetic joint infection Productivity Recording of previous events Registries Replacement Arthroplasty Research Research Design Research Infrastructure Research Methodology Research Personnel Research Project Grants Resources Risk Adjustment Risk Factors Science Services Severity of illness Standardization Statistical Data Interpretation Training Translational Research United States National Institutes of Health clinical center collaboratory data management data registry data resource data warehouse flexibility high standard implementation research improved informatics tool innovation next generation novel programs protocol development radiological imaging statistics study population success surgical risk systems research

项目摘要

ABSTRACT - METHODOLOGY CORE Clinical research in total joint arthroplasty (TJA) demands the highest standards of study design while leveraging existing data sources and adopting standardized definitions and novel clinical research methodologies. TJA researchers need to be well-trained and supported if they are to respond effectively to current and emerging research gaps in TJA. The Mayo Core Center for Clinical Research in Total Joint Arthroplasty (CORE-TJA) Methodology Core will build upon Mayo’s existing methodology resources to advance the science of TJA clinical research at the national level by providing high-quality consulting, education and mentoring services, and state-of-the-art and novel methodology resources, facilitating optimal use of existing stand-alone or linked databases and clinical research networks, training of the next generation of TJA clinical investigators and building scientific collaborations. The Specific Aims of the CORE-TJA Methodology Core are: (1) To enhance TJA clinical research at the national level by providing consultation, education and mentoring services for TJA investigators, (2) To leverage existing databases and clinical research networks to identify the most informative study populations and study designs for TJA clinical research, and (3) To develop and disseminate novel methodologies applicable to observational and interventional study designs in TJA clinical research. Specifically, the Methodology Core will focus on 6 specific methodological areas in TJA research: methods to account for bias and confounding in TJA research, application of TJA-specific informatics tools for automated data extraction from the electronic health records, patient-reported outcomes research, clinical trials embedded in registries and/or healthcare systems, mixed- methods research and implementation research. The CORE-TJA Methodology Core will create a flexible, sustainable research infrastructure, trained workforce and synergistic collaborations at the national level.

摘要-方法论核心全关节置换术（TJA）的临床研究要求最高标准的研究设计，利用现有数据源，采用标准化定义和新的临床研究方法论。TJA研究人员需要得到良好的培训和支持，如果他们要有效地应对当前和新兴的研究差距在TJA。马约全关节临床研究核心中心关节成形术（CORE-TJA）方法学核心将建立在马约现有方法学资源的基础上，通过提供高质量的咨询，在国家层面推进TJA临床研究的科学，教育和指导服务，以及最先进和新颖的方法资源，利用现有的独立或链接的数据库和临床研究网络，培训下一代 TJA临床研究者和建立科学合作。CORE-TJA的具体目标方法核心是：（1）通过提供咨询，加强国家层面的TJA临床研究，为TJA研究者提供教育和指导服务，（2）利用现有的数据库和临床研究网络，以确定TJA临床研究中最具信息量的研究人群和研究设计（3）开发和传播适用于观测和研究的新方法， TJA临床研究中的干预性研究设计。具体而言，方法论核心将侧重于6 TJA研究中的具体方法领域：TJA研究中解释偏倚和混淆的方法，应用TJA专用信息学工具，从电子健康记录中自动提取数据，患者报告的结局研究，登记研究和/或医疗保健系统中嵌入的临床试验，混合- 方法研究和实施研究。CORE-TJA方法论核心将创建一个灵活的，可持续的研究基础设施、训练有素的劳动力和国家一级的协同合作。