Admin Core

项目总结--行政核心 我们建议创建一个多机构的经络病相关癫痫研究 将结合高通量技术对癫痫相关离子进行功能评估的中心 通道基因变异与高含量的人类神经元和动物模型系统。该中心将是 由3个研究项目和2个科学核心组成的综合集合，涉及 学术界和工业界的科学家。具体地说，我们的中心将涉及20多名科学家和 附属于5个学术医学中心、3个独立研究医院和2个行业的医生 合作伙伴共同研究电压门控离子通道变异的功能后果 基因是遗传性癫痫最常被发现的原因。这项研究将是跨学科的 涉及新技术和独特资源的多面性。集结的调查组是 合议性和协作性，这将有助于全面成功。 行政核心将负责管理和协调中心#年的所有主要活动。 以最有效率和最具成本效益的方式实现我们的主要目标和实现里程碑。这 行政监督将涉及协调中心的所有研究部门、沟通 在所有参与者之间，以及来自不同专业和非专业的其他利益相关者的参与 社区合作伙伴。行政核心的目标是：1)管理和协调所有行政事务 中心的合作活动；2)促进参与机构之间的沟通和 社区合作伙伴；以及3)使公众了解中心的活动并确保资源共享。

PROJECT SUMMARY – ADMINISTRATIVE CORE We propose to create a multi-institutional CHANNELOPATHY-ASSOCIATED EPILEPSY RESEARCH CENTER that will combine high-throughput technologies for functional evaluation of epilepsy-associated ion channel gene variants with high-content human neuron and animal model systems. The Center will be comprised of an integrated set of 3 research projects and 2 scientific cores involving a synergistic mixture of academic and industry scientists. Specifically, our Center will involve the efforts of more than 20 scientists and physicians affiliated with 5 academic medical centers, 3 free standing research hospitals, and 2 industry partners working together to investigate the functional consequences of variants in voltage-gated ion channel genes that are the most frequently discovered cause of genetic epilepsy. The research will be interdisciplinary and multi-faceted involving novel technologies and unique resources. The assembled investigative team is collegial and collaborative and this will contribute to the overall success. The Administrative Core will be responsible for managing and coordinating all major activities of the Center in the most efficient and cost effective manner to accomplish our major goals and to achieve milestones. This administrative oversight will involve coordination of all research components of the Center, communication among all participants, and engagement of other stakeholders from various professional and non-professional community partners. The aims of the Administrative core are: 1) to manage and coordinate all administrative and collaborative activities of the Center; 2) to facilitate communication across participating institutions and community partners; and 3) to enable public awareness of Center activities and ensure resource sharing.