Pilot and Feasibility Component

试点和可行性部分

• 批准号: 10203941
• 负责人: Alfred L. George
• 金额: $ 8.64万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10203941
• 关键词: Animal Model; Award; Clinical; Clinical Investigator; Clinical Trials; Collaborations; Development; Environment; Evaluation; Fostering; Funding; Future; Goals; Growth; Kidney; Kidney Diseases; Lead; Mission; Modality; Patients; Pre-Clinical Model; Prevention; Research; Research Personnel; Research Project Grants; Services; Talents; Testing; Therapeutic; Time; Translating; Translational Research; United States National Institutes of Health; Universities; Vision; base; career development; collaborative environment; feasibility research; improved; innovation; meetings; novel therapeutics; programs; success; symposium; synergism; therapeutic development; therapeutic target; therapy development

PROJECT SUMMARY The mission of the George M. O'Brien Kidney Research Core Center at Northwestern University (NU- GoKIDNEY) is to join basic and clinical investigators to conduct translational research focused on the discovery of novel therapeutic modalities for patients with kidney diseases. We envision that the services provided by the Preclinical Models Core (Core A), the Therapeutics Development Core (Core B) and the Clinical and Translational Core (Core C) will support the development of therapies for testing in animal models and will facilitate the advancement of potential candidates into clinical trials. To achieve this ambitious vision, we will implement a Pilot and Feasibility Program that will embrace the NU-GoKIDNEY Center's Mission and leverage our Cores to deliver three short-term goals: 1) provide funds for research with high translational potential; 2) attract exceptional early-stage investigators or investigators previously outside the kidney research sphere to study kidney diseases; and 3) enhance within- and cross-institutional collaborations. By funding projects with high translational potential from investigators who propose to utilize the NU-GoKIDNEY Center's Cores to identify therapeutic targets, we anticipate that our Pilot and Feasibility Program will accomplish five long-term goals: 1) garner additional funding; 2) promote career development of early-stage investigators; 3) expand the expertise of kidney-focused investigators; 4) increase the number of collaborative products; and 5) promote synergy between the three Cores of the NU-GoKIDNEY Center and increase therapeutic deliverables as the ultimate mission of the NU-GoKIDNEY Center. As such, we anticipate that over time our Pilot and Feasibility Program will promote growth in NIH and other funding, will infuse the workforce with new creative talent and will foster a synergistic and collaborative culture on and across campuses. Ultimately, the scientific environment of the NU-GoKIDNEY Center will spur innovations and lead to better treatments for patients with kidney diseases.

项目总结 西北大学乔治·M·奥布莱恩肾脏研究核心中心的使命 GoKIDNEY)将与基础和临床研究人员一起进行专注于 发现肾脏疾病患者的新治疗方式。我们设想这些服务 由临床前模型核心(核心A)、治疗发展核心(核心B)和 临床和翻译核心(核心C)将支持动物模型试验疗法的开发 并将促进潜在候选人进入临床试验。为了实现这一雄心勃勃的愿景， 我们将实施一项试点和可行性计划，该计划将包括NU-GoKIDNEY中心的使命和 利用我们的核心来实现三个短期目标：1)为高转化率的研究提供资金 潜力；2)吸引特殊的早期研究人员或以前未参与肾脏研究的研究人员 (3)加强机构内和机构间的合作。通过提供资金 来自研究人员的具有高翻译潜力的项目，他们建议利用NU-GoKIDNEY中心的 为了确定治疗靶点，我们预计我们的试点和可行性计划将实现五个目标 长期目标：1)获得额外资金；2)促进早期调查人员的职业发展；3) 扩大以肾脏为重点的研究人员的专业知识；4)增加协作产品的数量；5) 促进NU-GoKidney中心三个核心之间的协同作用，增加治疗交付 作为努戈基德尼中心的终极使命。因此，我们预计随着时间的推移，我们的飞行员和 可行性计划将促进NIH的增长和其他资金，将为劳动力注入新的创造力 它将培养人才，并将在校园内外培养协同和协作的文化。归根结底，科学的 NU-GoKidney中心的环境将激励创新，并为患者带来更好的治疗 肾脏疾病。