Dissemination of a fiber-based optoacoustic neurostimulation device

基于光纤的光声神经刺激装置的推广

基本信息

  • 批准号:
    10478421
  • 负责人:
  • 金额:
    $ 14.93万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2018
  • 资助国家:
    美国
  • 起止时间:
    2018-09-30 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

Project Summary This administrative supplement for parent R01 NS1097914 (9/30/2018 to 6/30/2023), titled “Unveiling the mechanisms of ultrasound neuromodulation via spatially confined stimulation and temporally resolved recording”, aims at a small dissemination of a fiber optoacoustic emitter that allows ultrasound neuromodulation at ultrahigh special precision. The parental grant aims to perform a systematic analysis of the cellular and biophysical mechanisms of ultrasound stimulation at sub-cellular level, in cultured primary neurons and in different brain regions of awake mice, through development of novel technologies. Under support of the parental R01, the PI and coworkers developed a miniature fiber optoacoustic emitter (FOE) that delivers localized ultrasound with an unprecedented sub-millimeter spatial resolution. This technical advancement has enabled a deeper understanding of the mechanisms underlying acoustic stimulation. By applying FOE to mouse brain, direct acoustic stimulation of cortex neurons without involvement of cochlear pathway was demonstrated. Moreover, by harnessing a tapered FOE for stimulation at single neuron level, it was found that the excitatory neurons and inhibitory neurons have different thresholds in response to FOE stimulation. Both the membrane-deformation related fast physical response and a channel-related slow response are revealed. The proposed dissemination aims to bring FOEs to a broad spectrum of neuronal systems, including mouse cortex, monkey cortex, corneal neurons, and mouse central thalamus. Based on the need for novel neuromodulation technology, we have identified a small cohort of end-users. For delivery, we will assemble all the components into a compact and portable fiber optoacoustic modulation unit. Training will take a two-step approach. First, we will invite students/postdoctoral fellows in the end-users’ lab to the PI’s lab to directly visualize the demonstration of our neuromodulation device. We will then deliver the complete system and send one graduate student to the end users’ lab to carry out a hands-on training. Considering the different needs in end-users’ laboratory, we will take an individualized evaluation plan to maximize the potential of our device. Evaluation will be performed through meetings with end users and documented as evaluation reports at pre-, post-training, mid-term, and end of the project period. Specifically, our team will measure the pre- and post-training confidence level of skills/knowledge regarding use of the resource. The end users will quantitatively evaluate the benefits of the technology/resource over other options. Through development of alternative approaches, our team will address potential hurdles when integrating FOE with the recording technology in end user’s lab. It is expected that dissemination of the FOE technology not only will broaden the understanding of acoustic neuromodulation mechanism, but also will initiate and/or facilitate long-term collaborations with the end users.
项目摘要 本行政补充文件针对母公司R 01 NS 1097914(2018年9月30日至2023年6月30日),标题为“揭开 通过空间限制刺激和时间分辨记录的超声神经调节机制”, 目的是一个小的传播光纤光声发射器,允许超声神经调制在10000000美元。 特别精确。父母补助金的目的是进行细胞和生物物理的系统分析, 在亚细胞水平上,在培养的原代神经元和不同脑中超声刺激的机制 清醒小鼠的区域,通过开发新的技术。在亲本R 01的支持下,PI 和同事开发了一种微型光纤光声发射器(FOE), 前所未有的亚毫米空间分辨率。这一技术进步使更深层次的 了解声学刺激的机制。通过将FOE应用于小鼠大脑,直接 证实了声刺激皮质神经元而不涉及耳蜗通路。此外,委员会认为, 通过利用锥形FOE在单个神经元水平进行刺激,发现兴奋性神经元和 抑制性神经元响应于FOE刺激具有不同的阈值。膜变形 相关的快速物理响应和通道相关的慢响应。拟议的传播 旨在将FOE带到广泛的神经系统,包括小鼠皮层,猴子皮层,角膜 神经元和小鼠中央丘脑。基于对新型神经调节技术的需求,我们 确定了一小部分终端用户对于交付,我们将组装成一个紧凑的所有组件, 便携式光纤光声调制单元。培训将分两步进行。首先,我们将邀请 最终用户实验室的学生/博士后研究员到PI的实验室直接可视化我们的演示 神经调节装置然后我们将交付完整的系统,并派一名研究生到最后 用户实验室进行实际操作培训。考虑到最终用户实验室的不同需求, 个性化的评估计划,以最大限度地发挥我们设备的潜力。评价将通过 在培训前、培训后、培训中期和培训结束时与最终用户举行会议,并将其记录为评估报告。 项目期间。具体而言,我们的团队将衡量培训前和培训后技能/知识的信心水平 关于资源的使用。最终用户将定量评估技术/资源的好处 而不是其他选择通过开发替代方法,我们的团队将解决潜在的障碍 在最终用户实验室中将FOE与录音技术集成时,预计, FOE技术不仅将拓宽对听神经调制机制的理解, 发起和/或促进与最终用户的长期合作。

项目成果

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Ji-Xin Cheng其他文献

Ji-Xin Cheng的其他文献

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{{ truncateString('Ji-Xin Cheng', 18)}}的其他基金

2023 Chemical Imaging Gordon Research Conferences
2023 年化学成像戈登研究会议
  • 批准号:
    10605394
  • 财政年份:
    2023
  • 资助金额:
    $ 14.93万
  • 项目类别:
Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator
使用微波开口环谐振器的亚毫米精度无线神经调节
  • 批准号:
    10669784
  • 财政年份:
    2022
  • 资助金额:
    $ 14.93万
  • 项目类别:
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data Science
通过先进仪器和数据科学的集成进行代谢重编程的高内涵高速化学成像
  • 批准号:
    10543185
  • 财政年份:
    2022
  • 资助金额:
    $ 14.93万
  • 项目类别:
Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator
使用微波开口环谐振器的亚毫米精度无线神经调节
  • 批准号:
    10516429
  • 财政年份:
    2022
  • 资助金额:
    $ 14.93万
  • 项目类别:
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data Science
通过先进仪器和数据科学的集成进行代谢重编程的高内涵高速化学成像
  • 批准号:
    10344774
  • 财政年份:
    2022
  • 资助金额:
    $ 14.93万
  • 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
  • 批准号:
    10491322
  • 财政年份:
    2021
  • 资助金额:
    $ 14.93万
  • 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
  • 批准号:
    10271761
  • 财政年份:
    2021
  • 资助金额:
    $ 14.93万
  • 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
  • 批准号:
    10675665
  • 财政年份:
    2021
  • 资助金额:
    $ 14.93万
  • 项目类别:
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems
振动光谱成像揭示生命系统中隐藏的特征
  • 批准号:
    10206200
  • 财政年份:
    2020
  • 资助金额:
    $ 14.93万
  • 项目类别:
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems
振动光谱成像揭示生命系统中隐藏的特征
  • 批准号:
    10660979
  • 财政年份:
    2020
  • 资助金额:
    $ 14.93万
  • 项目类别:

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