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Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator

使用微波开口环谐振器的亚毫米精度无线神经调节

基本信息

批准号：
10516429
负责人：
Ji-Xin Cheng
金额：
$ 24.75万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10516429
关键词：
Action Potentials Address Axon Back Biophotonics Brain Brain Injuries Caliber Cellular Phone Chemicals Chronic Clinical Treatment Communication Contrast Media Copper Couples Development Device or Instrument Development Devices Doctor of Philosophy Electromagnetic Energy Epilepsy Exposure to Frequencies Generations Human Image Implant In Vitro Label Magnetism Mediating Methods Modeling Monitor Mus Neural Inhibition Neuraxis Neurons Ocular dominance columns Optics Pacemakers Pain management Penetration Peripheral Nervous System Peripheral Nervous System Diseases Photons Reporting Research Research Personnel Resolution Risk Scientist Seizures Spottings Technology Time Tissues Titanium Toxic effect Transcranial magnetic stimulation Visual Cortex Work Yang base biomaterial compatibility brain tissue cranium design electric field in vivo Model microwave electromagnetic radiation minimally invasive mouse model multidisciplinary neural stimulation neuroregulation novel relating to nervous system ultrasound wireless wireless electronic wireless fidelity

项目摘要

Project Summary Minimally invasive neural modulation at sub-millimeter spatial resolution remains a critical yet unmet biomedical need. Researchers have explored a broad spectrum of electromagnetic wave and developed wireless neuromodulation methods. Due to its long wavelength, transcranial magnetic stimulation does not provide sufficient spatial resolution to target a functional unit such as a single ocular dominance column in the visual cortex or a diseased peripheral nerve. On the other hand, photons, with their short wavelength, offer micrometer-scale spatial precision but can barely penetrate couple hundred micrometers into the tissue, not to mention the human skull. Microwave (MW), with frequencies between 300 MHz and 300 GHz, fills the gap between optical wave and magnetic wave, yet, has rarely been explored for neuromodulation. We propose a minimally invasive neuromodulation device by taking advantage of a microwave split ring resonator (SRR) design. The SRR has a perimeter of approximately one half of MW wavelength, thus acting as a resonant antenna. It couples the microwave wirelessly and concentrates the microwave at the gap, producing a localized electrical field of ~100 μm in space. Our scientific premise is based on the nonthermal neural inhibitory effect of microwave and the resonance effect of the SRR. The SRR produces concentrated microwave and allows for neuromodulation beyond the microwave diffraction limit, reaching ~100 μm spatial precision. In the proposed work, we will design and fabricate an implantable SRR with titanium for its superior biocompatibility. We will then validate the SRR’s potential in neural inhibition using primary neurons in vitro and a mouse epilepsy model in vivo. By accomplishing the proposed studies, we will have developed a biocompatible and implantable neuromodulation device. The centimeter-scale penetration depth provided by microwave and the sub-millimeter spatial precision provided by SRR promises broad biomedical applications. For central nervous system, our technology allows minimally invasive transcranial modulation of neural activities inside brain and for clinical treatment of epilepsy. A multi-disciplinary team with complementary expertise is assembled to implement the proposed activities.

项目总结