Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator
使用微波开口环谐振器的亚毫米精度无线神经调节
基本信息
- 批准号:10516429
- 负责人:
- 金额:$ 24.75万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-08-01 至 2025-07-31
- 项目状态:未结题
- 来源:
- 关键词:Action PotentialsAddressAxonBackBiophotonicsBrainBrain InjuriesCaliberCellular PhoneChemicalsChronicClinical TreatmentCommunicationContrast MediaCopperCouplesDevelopmentDevice or Instrument DevelopmentDevicesDoctor of PhilosophyElectromagnetic EnergyEpilepsyExposure toFrequenciesGenerationsHumanImageImplantIn VitroLabelMagnetismMediatingMethodsModelingMonitorMusNeural InhibitionNeuraxisNeuronsOcular dominance columnsOpticsPacemakersPain managementPenetrationPeripheral Nervous SystemPeripheral Nervous System DiseasesPhotonsReportingResearchResearch PersonnelResolutionRiskScientistSeizuresSpottingsTechnologyTimeTissuesTitaniumToxic effectTranscranial magnetic stimulationVisual CortexWorkYangbasebiomaterial compatibilitybrain tissuecraniumdesignelectric fieldin vivo Modelmicrowave electromagnetic radiationminimally invasivemouse modelmultidisciplinaryneural stimulationneuroregulationnovelrelating to nervous systemultrasoundwirelesswireless electronicwireless fidelity
项目摘要
Project Summary
Minimally invasive neural modulation at sub-millimeter spatial resolution remains a critical yet unmet
biomedical need. Researchers have explored a broad spectrum of electromagnetic wave and developed
wireless neuromodulation methods. Due to its long wavelength, transcranial magnetic stimulation does not
provide sufficient spatial resolution to target a functional unit such as a single ocular dominance column in the
visual cortex or a diseased peripheral nerve. On the other hand, photons, with their short wavelength, offer
micrometer-scale spatial precision but can barely penetrate couple hundred micrometers into the tissue, not to
mention the human skull. Microwave (MW), with frequencies between 300 MHz and 300 GHz, fills the gap
between optical wave and magnetic wave, yet, has rarely been explored for neuromodulation. We propose a
minimally invasive neuromodulation device by taking advantage of a microwave split ring resonator (SRR)
design. The SRR has a perimeter of approximately one half of MW wavelength, thus acting as a resonant
antenna. It couples the microwave wirelessly and concentrates the microwave at the gap, producing a
localized electrical field of ~100 μm in space. Our scientific premise is based on the nonthermal neural
inhibitory effect of microwave and the resonance effect of the SRR. The SRR produces concentrated
microwave and allows for neuromodulation beyond the microwave diffraction limit, reaching ~100 μm spatial
precision. In the proposed work, we will design and fabricate an implantable SRR with titanium for its superior
biocompatibility. We will then validate the SRR’s potential in neural inhibition using primary neurons in vitro and
a mouse epilepsy model in vivo. By accomplishing the proposed studies, we will have developed a
biocompatible and implantable neuromodulation device. The centimeter-scale penetration depth provided by
microwave and the sub-millimeter spatial precision provided by SRR promises broad biomedical applications.
For central nervous system, our technology allows minimally invasive transcranial modulation of neural
activities inside brain and for clinical treatment of epilepsy. A multi-disciplinary team with complementary
expertise is assembled to implement the proposed activities.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Ji-Xin Cheng其他文献
Ji-Xin Cheng的其他文献
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{{ truncateString('Ji-Xin Cheng', 18)}}的其他基金
2023 Chemical Imaging Gordon Research Conferences
2023 年化学成像戈登研究会议
- 批准号:
10605394 - 财政年份:2023
- 资助金额:
$ 24.75万 - 项目类别:
Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator
使用微波开口环谐振器的亚毫米精度无线神经调节
- 批准号:
10669784 - 财政年份:2022
- 资助金额:
$ 24.75万 - 项目类别:
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data Science
通过先进仪器和数据科学的集成进行代谢重编程的高内涵高速化学成像
- 批准号:
10543185 - 财政年份:2022
- 资助金额:
$ 24.75万 - 项目类别:
High-content High-speed Chemical Imaging of Metabolic Reprogramming by Integration of Advanced Instrumentation and Data Science
通过先进仪器和数据科学的集成进行代谢重编程的高内涵高速化学成像
- 批准号:
10344774 - 财政年份:2022
- 资助金额:
$ 24.75万 - 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
- 批准号:
10491322 - 财政年份:2021
- 资助金额:
$ 24.75万 - 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
- 批准号:
10271761 - 财政年份:2021
- 资助金额:
$ 24.75万 - 项目类别:
Mapping Cancer Metabolism by Mid-infrared Photothermal Microscopy
通过中红外光热显微镜绘制癌症代谢图
- 批准号:
10675665 - 财政年份:2021
- 资助金额:
$ 24.75万 - 项目类别:
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems
振动光谱成像揭示生命系统中隐藏的特征
- 批准号:
10206200 - 财政年份:2020
- 资助金额:
$ 24.75万 - 项目类别:
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems
振动光谱成像揭示生命系统中隐藏的特征
- 批准号:
10660979 - 财政年份:2020
- 资助金额:
$ 24.75万 - 项目类别:
Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living Systems
振动光谱成像揭示生命系统中隐藏的特征
- 批准号:
10439640 - 财政年份:2020
- 资助金额:
$ 24.75万 - 项目类别:
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