Wireless Implantable Mechano-Acoustic Recording Device

无线植入式机械声记录设备

• 批准号: 10484423
• 负责人: Cameron Good
• 金额: $ 25.96万
• 依托单位: NEUROLUX, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2023-09-21
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10484423
• 关键词: 3-Dimensional; Accelerometer; Acoustics; Adult; Anesthesia procedures; Animal Behavior; Animal Model; Animals; Arousal; Behavior; Behavioral; Benchmarking; Bluetooth; Chronic; Communities; Complex; Computer software; Consumption; Coupled; Data; Data Collection; Development; Devices; Disease; Drug Delivery Systems; Environment; Future; General Anesthesia; Harvest; Heart; Heart Rate; Implant; Individual; Infrastructure; Investigation; Laboratories; Libraries; Location; Locomotion; Measurement; Mediating; Methods; Monitor; Motion; Mus; Muscle; Neurons; Neurosciences; Neurosciences Research; Noise; Operative Surgical Procedures; Performance; Peripheral; Phase; Physiological; Physiology; Preparation; Procedures; Pulse Oximetry; Rattus; Reader; Reading; Records; Recovery; Research; Resolution; Respiration; Rodent; Signal Transduction; Small Business Innovation Research Grant; Social Behavior; Social Environment; Social Interaction; System; Technology; Temperature; Testing; Time; Translations; Universities; Validation; Washington; Work; awake; base; behavior test; cost; data acquisition; data exchange; design; effective therapy; experimental study; in vivo; in vivo evaluation; machine vision; miniaturize; minimally invasive; monitoring device; neuropsychiatric disorder; new technology; novel strategies; operation; optogenetics; pre-clinical; programs; pup; radio frequency; relating to nervous system; respiratory; response; signal processing; social; social factors; social group; subcutaneous; technology development; technology validation; time use; tool; vibration; wireless; wireless electronic

PROJECT SUMMARY - ABSTRACT We will design a fully implantable, wireless, battery-free, Mechano-Acoustic (MA) device that allows for multi- parameter physiological data acquisition from freely moving small animal models, via use of high bandwidth triaxial accelerometers. The proposed technology records relevant vital sign information such as the heart and respiration rate and temperature, and other general features about the animal that include locomotion and body orientation. Each of these features are determined in parallel from subtle motions detected with this platform using the most advanced inertial measurement unit (IMU) technology and transmitted wirelessly and analyzed in real-time using Bluetooth Low Energy (BLE) 5.2 to an external reader system – all isolated to individual subjects within experimental contexts spanning single to multi-animal behaviors. This approach allows other experimental approaches (video tracking, neural recording, closed-loop optogenetics, etc.) to be directly coupled to the recorded physiological data. Integration of a BLE 5.2 reading board into the existing NeuroLux Power Distribution Control (PDC) box will enable simultaneous use with other devices in NeuroLux’s product portfolio, including fully implantable optogenetic devices and wireless drug-delivery systems that are currently in widespread use across various parts of the neuroscience community. By delivering both power and data wirelessly, and by entirely eliminating all external fixtures and physical tethers on the animal, the proposed technology enables chronic physiological recordings in three-dimensional naturalistic environments, from isolated individuals or social groups, in ways that are fundamentally impossible with conventional hardware infrastructure. This low-cost manufacturable system is fully compatible with the NeuroLux radio frequency wireless electronic platform and control software, allowing us to leverage the strengths of an existing commercial platform currently in use in >150 laboratories worldwide to further advance neuroscience research capabilities.

项目摘要-摘要 我们将设计一种完全可植入的、无线的、无电池的机械声学(MA)设备，允许多个 利用高带宽从自由活动的小动物模型中获取参数生理数据 三轴加速度计。拟议的技术记录了相关的生命体征信息，如心脏和 呼吸频率和温度，以及动物的其他一般特征，包括运动和身体 定位。这些特征中的每一个都是根据该平台检测到的细微运动并行确定的 采用最先进的惯性测量组合(IMU)技术，无线传输并分析 使用蓝牙低能耗(BLE)5.2实时连接到外部读卡器系统-所有这些都与个人隔离 实验背景下的受试者跨越了从单一动物到多个动物的行为。此方法允许其他 实验方法(视频跟踪、神经记录、闭环光遗传学等)直接耦合 记录的生理数据。将BLE 5.2阅读板集成到现有的Neurolux Power中 配送控制(PDC)盒将支持与Neurolux产品组合中的其他设备同时使用， 包括完全可植入的光遗传设备和无线药物输送系统，目前正在 广泛应用于神经科学界的各个领域。通过同时提供电力和数据 通过无线方式，并通过完全消除动物身上的所有外部固定装置和物理拴系，建议的 技术能够在三维自然环境中进行慢性生理记录，从 孤立的个人或社会团体，以传统硬件根本不可能实现的方式 基础设施。这种低成本的可制造系统与Neurolux射频完全兼容 无线电子平台和控制软件，使我们能够利用现有商业 该平台目前在全球150个实验室中使用，以进一步提升神经科学研究能力。