Wake Forest Atrium HeartShare Clinical Center

维克森林中庭 HeartShare 临床中心

基本信息

项目摘要

Project Summary Heart Failure with Preserved Ejection Fraction (HFpEF) is the most common form of HF in the US and is associated with high morbidity and mortality. However, its pathophysiology is incompletely understood, and most trials have been neutral such that few evidence-based treatments exist. In response, NIH convened 2 workshops co-led by Dr. Kitzman (PI). The highest priority research recommendation was a coordinated effort to create a large cohort of HFpEF patients and controls and perform comprehensive, deep phenotyping. This became the basis for HeartShare, whose ultimate goals are to discover novel HFpEF mechanisms, subtypes, and therapeutic targets. Our Wake Forest - Atrium HFpEF team is highly qualified to serve as a Clinical Center and make robust, over-arching contributions to HeartShare. Dr. Kitzman is internationally recognized as a thought-leader in HFpEF with a sustained track record of developing novel concepts regarding HFpEF pathogenesis, mechanisms, and outcomes and designing and conducting innovative studies to test them. His team has extensive experience in all key aspects of the HeartShare program, particularly in recruiting, retaining, and phenotyping diverse populations of HFpEF patients and controls, often significantly exceeding goals for racial and gender diversity. Our institutions have ~15,000 HFpEF clinical visits annually. In all, our team has led or helped lead recruitment and phenotyping for 69 studies, mostly NIH-sponsored, with 15,354 participants, demonstrating our ability to fulfill HeartShare recruitment and phenotyping goals. Data from these studies will be contributed to the Cohort phase of HeartShare. We will make robust contributions to HeartShare by achieving 4 Specific Aims: Aim 1) Provide ‘thought leadership’ in collaboration with the HeartShare Steering Committee; Aim 2) Contribute data, images, and stored specimens cohort phase of HeartShare from our numerous studies of HFpEF and controls, and identify and phenotype HFpEF patients and controls from the electronic health record using robust bioinformatics tools; Aim 3) Recruit, consent, enroll and follow at least 250 HFpEF patients plus controls (type and number to be determined by consensus); Aim 4) Conduct state-of- the-art deep phenotyping exams using a collaboratively determined protocol. Our phenotyping proposal is highly innovative, with advanced echo-Doppler and cardiac magnetic resonance imaging, CPET, physical activity monitoring, remote and artificial intelligence electrocardiography, sampling of skeletal muscle, adipose, blood, and microbiome, and mitochondrial energetics, and brain structure/function. Our diverse, cross- disciplinary team has the full range of complementary expertise and access to the robust resources of two large, closely affiliated health systems to ensure fulfillment of all HeartShare’s goals. We will help accelerate and optimize the program’s success with our insight, creativity, and sustained track record of collaboration, innovation, and dissemination.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)

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DALANE W KITZMAN其他文献

DALANE W KITZMAN的其他文献

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{{ truncateString('DALANE W KITZMAN', 18)}}的其他基金

Repurposing of Metormin for Older Patients with HFpEF
老年 HFpEF 患者重新使用美托明
  • 批准号:
    10434271
  • 财政年份:
    2022
  • 资助金额:
    $ 27.47万
  • 项目类别:
Repurposing of Metormin for Older Patients with HFpEF
老年 HFpEF 患者重新使用美托明
  • 批准号:
    10672897
  • 财政年份:
    2022
  • 资助金额:
    $ 27.47万
  • 项目类别:
Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF Trial
老年急性 HFpEF 患者的身体康复 - REHAB-HFpEF 试验
  • 批准号:
    10683332
  • 财政年份:
    2022
  • 资助金额:
    $ 27.47万
  • 项目类别:
Physical Rehabilitation for Older Patients with Acute HFpEF-The REHAB-HFpEF Trial
老年急性 HFpEF 患者的身体康复 - REHAB-HFpEF 试验
  • 批准号:
    10501900
  • 财政年份:
    2022
  • 资助金额:
    $ 27.47万
  • 项目类别:
Wake Forest Atrium HeartShare Clinical Center
维克森林中庭 HeartShare 临床中心
  • 批准号:
    10327453
  • 财政年份:
    2021
  • 资助金额:
    $ 27.47万
  • 项目类别:
Wake Forest Atrium HeartShare Clinical Center
维克森林中庭 HeartShare 临床中心
  • 批准号:
    10678972
  • 财政年份:
    2021
  • 资助金额:
    $ 27.47万
  • 项目类别:
Improving the usage and impact of the Integrated Aging Studies Databank and Registry
改善综合老龄化研究数据库和登记处的使用和影响
  • 批准号:
    10408207
  • 财政年份:
    2018
  • 资助金额:
    $ 27.47万
  • 项目类别:
Coordinating Center of the Claude D. Pepper Older Americans Independence Centers
克劳德·D·佩珀美国老年人独立中心协调中心
  • 批准号:
    10163762
  • 财政年份:
    2018
  • 资助金额:
    $ 27.47万
  • 项目类别:
Coordinating Center of the Claude D. Pepper Older Americans Independence Centers
克劳德·D·佩珀美国老年人独立中心协调中心
  • 批准号:
    10449365
  • 财政年份:
    2018
  • 资助金额:
    $ 27.47万
  • 项目类别:
Pepper OAIC Coordinating Center
佩珀 OAIC 协调中心
  • 批准号:
    10621613
  • 财政年份:
    2018
  • 资助金额:
    $ 27.47万
  • 项目类别:

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