Pepper OAIC Coordinating Center

佩珀 OAIC 协调中心

• 批准号: 10621613
• 负责人: DALANE W KITZMAN
• 金额: $ 64万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-15 至 2028-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10621613
• 关键词: Acceleration; Administrative Supplement; Aging; American; Award; Capsicum; Clinical Research; Collaborations; Communication; Communities; Data; Data Analyses; Development; Directories; Educational Curriculum; Elderly; Evaluation; Fostering; Funding; Goals; Growth; Health system; Healthcare; Healthcare Systems; Individual; Institution; Interview; Leadership; Multicenter Studies; Periodicals; Phase; Philosophy; Policies; Process; Productivity; Professional Organizations; Protocols documentation; Publications; Registries; Research; Research Personnel; Resources; Role; Structure; Testing; Trust; United States National Institutes of Health; Work; apprenticeship; career; career development; data integration; data sharing; evidence base; experience; flexibility; forest; implementation science; improved; innovation; instrument; medical schools; meetings; member; multidisciplinary; next generation; novel; pandemic disease; programs; skills; social media; synergism; web site; webinar; working group

The Coordinating Center (CC) for the Older Americans Independence Centers (OAIC) Program plans, initiates, facilitates, and coordinates activities that maximize OAIC collaborations. Our guiding philosophy is to focus on activities that promise high impact but would be difficult for individual OAICs to achieve on their own, and which result in collaborations that unlock synergy, thereby making the whole (the OAIC program) greater than its parts (the individual centers and investigators). Our preliminary data show that the present cycle has been the most successful and productive to date. The proposed new cycle will build on and extend these accomplishments with initiatives embedded in the following four Specific Aims, which were informed by our preliminary data, including our evaluation processes and our structured interviews with three key groups of stakeholders: directors of all 15 OAICs, a panel of early career investigators, and NIA program officials. Specific Aim 1. Enhance communications and coordination within the OAIC program and with the greater aging research community. Specific Aim 2. Facilitate and promote OAIC-themed collaborative research. Specific Aim 3. Enhance the development of the next generation of researchers in aging. Specific Aim 4. Accelerate implementation of key OAIC research findings into member health care systems and their communities. We will achieve these aims by capitalizing on: 1) our 17 years of experience and earned trust in progressively building collaborations; 2) an expanded, multi-disciplinary, cohesive, multi-institutional team of experienced leaders with complementary skills and well-defined roles; 3) our well established processes, including four working groups and inclusion of key stakeholders; 4) regular input and guidance from the OAIC Directors Committee and NIA program officials; and 5) continously evaluating progress toward each aim and overall goals of the program. This proposed renewal of the CC will further increase the breadth and depth of OAIC collaboration, provide vital new research opportunities, particularly for early career investigators, promote career development of new investigators, and disseminate key OAIC research findings to improve the healthcare of older Americans.

美国老年人独立中心（OAIC）方案协调中心（CC）计划，发起， 促进和协调各项活动，最大限度地加强内审办的协作。我们的指导思想是专注于 有希望产生重大影响，但各独立审计员办公室难以单独完成的活动， 导致合作，解锁协同作用，从而使整个（OAIC计划）大于其 部分（各中心和研究者）。我们的初步数据显示，目前的周期是 迄今为止最成功和最富有成效的。拟议的新周期将以这些为基础， 通过以下四个具体目标中的举措取得的成就，这些目标是由我们的 初步数据，包括我们的评估过程和我们对三个关键群体的结构化访谈， 利益相关者：所有15个OAIC的主任，一个早期职业调查小组和NIA项目官员。 具体目标1。加强OAIC计划内部以及与更大的 老龄化研究社区。具体目标2。促进和推动以OAIC为主题的合作研究。 具体目标3。加强下一代老龄化研究人员的发展。具体目标4。 加快OAIC关键研究成果在成员医疗保健系统中的实施， 社区.我们将通过以下方式实现这些目标：1）我们17年的经验和赢得的信任， 逐步建立合作; 2）扩大，多学科，有凝聚力，多机构的团队， 经验丰富的领导者，具有互补的技能和明确的角色; 3）我们完善的流程， 包括四个工作组和主要利益相关者的参与; 4）OAIC的定期投入和指导 董事委员会和NIA项目官员; 5）不断评估每个目标的进展情况， 方案的总体目标。这次拟议的CC更新将进一步增加的广度和深度， OAIC合作，提供重要的新的研究机会，特别是为早期职业调查人员，促进 新调查员的职业发展，并传播OAIC的主要研究成果，以提高 美国老年人的医疗保健。

项目成果

Improving the Approach to Defining, Classifying, Reporting and Monitoring Adverse Events in Seriously Ill Older Adults: Recommendations from a Multi-stakeholder Convening.

改进重病老年人不良事件的定义、分类、报告和监测方法：多方利益相关者会议的建议。

• DOI: 10.1007/s11606-022-07646-7
• 发表时间: 2023
• 期刊: Journal of general internal medicine
• 影响因子: 5.7
• 作者: Baim-Lance,Abigail;Ferreira,KatelynB;Cohen,HarveyJay;Ellenberg,SusanS;Kuchel,GeorgeA;Ritchie,Christine;Sachs,GregA;Kitzman,Dalane;Morrison,RSean;Siu,Albert
• 通讯作者: Siu,Albert

Neurocognitive Impairments and Their Improvement Following Exercise and Dietary Interventions in Older Patients With Heart Failure With Preserved Ejection Fraction.

射血分数保留的老年心力衰竭患者运动和饮食干预后的神经认知障碍及其改善。

• DOI: 10.1161/circheartfailure.123.011134
• 发表时间: 2024
• 期刊: Circulation. Heart failure
• 作者: Schaich,ChristopherL;Hughes,TimothyM;Kitzman,DalaneW;Jung,Youngkyoo;Chen,Haiying;Nicklas,BarbaraJ;Houston,DeniseK;Brubaker,PeterH;Molina,AnthonyJA;Hugenschmidt,ChristinaE
• 通讯作者: Hugenschmidt,ChristinaE

Response by Brubaker et al to Letter Regarding "A Randomized, Controlled Trial of Resistance Training Added to Caloric Restriction Plus Aerobic Exercise Training in Obese Heart Failure With Preserved Ejection Fraction".

Brubaker 等人对关于“在保留射血分数的肥胖性心力衰竭中添加热量限制加有氧运动训练的阻力训练的随机对照试验”的信件的回复。

• DOI: 10.1161/circheartfailure.123.010419
• 发表时间: 2023
• 期刊: Circulation. Heart failure
• 作者: Brubaker,PeterH;Nelson,WBenjamin;Kitzman,DalaneW
• 通讯作者: Kitzman,DalaneW

Effect of Intensive Blood Pressure Control on Aortic Stiffness in the SPRINT-HEART.

• DOI: 10.1161/hypertensionaha.120.16676
• 发表时间: 2021-05-05
• 期刊: Hypertension (Dallas, Tex. : 1979)
• 作者: Upadhya B;Pajewski NM;Rocco MV;Hundley WG;Aurigemma G;Hamilton CA;Bates JT;He J;Chen J;Chonchol M;Glasser SP;Hung AM;Pisoni R;Punzi H;Supiano MA;Toto R;Taylor A;Kitzman DW;SPRINT Research Group
• 通讯作者: SPRINT Research Group

Semaglutide in HFpEF across obesity class and by body weight reduction: a prespecified analysis of the STEP-HFpEF trial.

• DOI: 10.1038/s41591-023-02526-x
• 发表时间: 2023-09
• 期刊: NATURE MEDICINE
• 影响因子: 82.9
• 作者: Borlaug, Barry A.;Kitzman, Dalane W.;Davies, Melanie J.;Rasmussen, Soren;Barros, Eric;Butler, Javed;Einfeldt, Mette Nygaard;Hovingh, G. Kees;Moller, Daniel Vega;Petrie, Mark C.;Shah, Sanjiv J.;Verma, Subodh;Abhayaratna, Walter;Ahmed, Fozia Z.;Chopra, Vijay;Ezekowitz, Justin;Fu, Michael;Ito, Hiroshi;Lelonek, Malgorzata;Melenovsky, Vojtech;Nunez, Julio;Perna, Eduardo;Schou, Morten;Senni, Michele;van der Meer, Peter;Von Lewinski, Dirk;Wolf, Dennis;Kosiborod, Mikhail N.
• 通讯作者: Kosiborod, Mikhail N.