Protein Networks as Synergistic Drivers of Membrane Remodeling

蛋白质网络作为膜重塑的协同驱动因素

• 批准号: 10484247
• 负责人: Jeanne Casstevens Stachowiak
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10484247
• 关键词: Administrative Supplement; African American; Biological; Biological Sciences; Biomedical Research; Biophysics; Defect; Disease; Employment; Environment; Faculty; Fellowship; Funding; Future; Goals; Human; Knowledge; Leadership; Malignant Neoplasms; Membrane; Mentors; Mentorship; Mission; Molecular; Pharmaceutical Preparations; Positioning Attribute; Preparation; Proteins; Public Health; Research; Research Activity; Research Design; Research Personnel; Science; Surface; Therapeutic; Training; Training Activity; Underrepresented Populations; United States National Institutes of Health; Vesicle; Vision; Work; biophysical model; career; design; disability; diversity and equity; falls; member; multidisciplinary; nervous system disorder; parent grant; pathogen; pre-doctoral; symposium; trafficking; training opportunity

SUMMARY ABSTRACT: Administrative Supplement to Promote Diversity for R35GM139531 This proposal is for an administrative supplement to R35GM139531, to promote diversity through the training of a predoctoral candidate. The candidate, Ketsia Zinga, is black/African American, a historically underrepresented group in the biological sciences. Importantly, through this supplement, Ketsia will have the opportunity to be trained at the multi-disciplinary interface of experimental and computational biophysics. Ketsia has expressed a specific desire for this multi-disciplinary training environment, which will be facilitated by two co-mentors: (i) Prof. Jeanne Stachowiak, an experimental biophysicist, and (ii) Prof. Pengyu Ren, a computational biophysicist. Notably, this unique training opportunity would be impossible without this administrative supplement because (i) the parent grant does not have sufficient funds, and (ii) additional funds are needed to incorporate a significant computational component into the existing aims of the project, which is necessary to meet Ketsia’s unique training goals. The key goal of the proposed supplemental work falls fully within the funded aims of R35GM139531. Specifically, the supplemental activities support two major goals of the funded project including: (i) understanding how biological membranes impact the assembly of protein condensates, and (ii) understanding the molecular mechanism behind the ability of protein condensates to bend membrane surfaces. Guided by these research goals, in combination with Ketsia’s career goals, we have designed a highly tailored training plan for Ketsia. Specific aspects of our plan include (i) co-mentoring by experimental and computational investigators, (ii) design of research activities that couple experimental findings to biophysical models, (iii) support from a diverse mentoring committee, (iv) opportunities to interact with faculty members from diverse groups, (iv) mentored application for graduate fellowships, (v) multiple opportunities to attend research conferences, (vi) targeted preparation for a future leadership position in the biomedical sciences, and (vii) mentorship through the transition to a postdoctoral position or other post-graduate employment. Taken together, these training and research activities will enable Ketsia to realize her vision of working at the interface of computational and experimental biophysics, while greatly enhancing her competitiveness for an exciting, independent scientific career in the biomedical sciences.

摘要：促进R35 GM 139531多样性的行政补充 本提案是对R35 GM 139531的行政补充，旨在通过以下培训促进多样性： 博士预科生候选人Ketsia Zinga是黑人/非洲裔美国人，历史上代表性不足 在生物科学领域。重要的是，通过这一补充，Ketsia将有机会成为 在实验和计算生物物理学的多学科界面接受培训。Ketsia表示， 这一多学科的培训环境的具体愿望，这将是由两个共同导师促进：（一）教授。 珍妮Stachowiak，实验生物药理学家，和（ii）教授Pengyu任，计算生物药理学家。 值得注意的是，如果没有这种行政补充，就不可能有这种独特的培训机会，因为： 父母补助金没有足够的资金，（二）需要额外的资金，以纳入一个重要的 计算组件到该项目的现有目标，这是必要的，以满足凯西亚的独特的 培训目标。拟议补充工作的主要目标福尔斯完全符合以下资助目标： R35GM139531。具体而言，补充活动支持资助项目的两个主要目标，包括： (i)了解生物膜如何影响蛋白质缩合物的组装，以及（ii）了解 蛋白质凝聚物能够使膜表面弯曲的分子机制。指导 结合Ketsia的职业目标，我们设计了一个高度定制的培训计划 为了凯西娅我们计划的具体方面包括（i）实验和计算研究人员的共同指导， (ii)设计研究活动，将实验结果与生物物理模型结合起来，㈢ 多样化的指导委员会，（四）与来自不同群体的教师互动的机会，（四） 指导申请研究生奖学金，（五）多次参加研究会议的机会，（六） 有针对性的准备，为未来的领导地位，在生物医学科学，和（七）导师，通过 过渡到博士后职位或其他研究生就业。总之，这些培训和 研究活动将使Ketsia能够实现她在计算和计算接口工作的愿景。 实验生物物理学，同时大大提高了她的竞争力，一个令人兴奋的，独立的科学 在生物医学科学的职业生涯。