Protein Networks as Synergistic Drivers of Membrane Remodeling

蛋白质网络作为膜重塑的协同驱动因素

• 批准号: 10484247
• 负责人: Jeanne Casstevens Stachowiak
• 金额: $ 7.68万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-02-01 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10484247
• 关键词: Administrative Supplement; African American; Biological; Biological Sciences; Biomedical Research; Biophysics; Defect; Disease; Employment; Environment; Faculty; Fellowship; Funding; Future; Goals; Human; Knowledge; Leadership; Malignant Neoplasms; Membrane; Mentors; Mentorship; Mission; Molecular; Pharmaceutical Preparations; Positioning Attribute; Preparation; Proteins; Public Health; Research; Research Activity; Research Design; Research Personnel; Science; Surface; Therapeutic; Training; Training Activity; Underrepresented Populations; United States National Institutes of Health; Vesicle; Vision; Work; biophysical model; career; design; disability; diversity and equity; falls; member; multidisciplinary; nervous system disorder; parent grant; pathogen; pre-doctoral; symposium; trafficking; training opportunity

SUMMARY ABSTRACT: Administrative Supplement to Promote Diversity for R35GM139531 This proposal is for an administrative supplement to R35GM139531, to promote diversity through the training of a predoctoral candidate. The candidate, Ketsia Zinga, is black/African American, a historically underrepresented group in the biological sciences. Importantly, through this supplement, Ketsia will have the opportunity to be trained at the multi-disciplinary interface of experimental and computational biophysics. Ketsia has expressed a specific desire for this multi-disciplinary training environment, which will be facilitated by two co-mentors: (i) Prof. Jeanne Stachowiak, an experimental biophysicist, and (ii) Prof. Pengyu Ren, a computational biophysicist. Notably, this unique training opportunity would be impossible without this administrative supplement because (i) the parent grant does not have sufficient funds, and (ii) additional funds are needed to incorporate a significant computational component into the existing aims of the project, which is necessary to meet Ketsia’s unique training goals. The key goal of the proposed supplemental work falls fully within the funded aims of R35GM139531. Specifically, the supplemental activities support two major goals of the funded project including: (i) understanding how biological membranes impact the assembly of protein condensates, and (ii) understanding the molecular mechanism behind the ability of protein condensates to bend membrane surfaces. Guided by these research goals, in combination with Ketsia’s career goals, we have designed a highly tailored training plan for Ketsia. Specific aspects of our plan include (i) co-mentoring by experimental and computational investigators, (ii) design of research activities that couple experimental findings to biophysical models, (iii) support from a diverse mentoring committee, (iv) opportunities to interact with faculty members from diverse groups, (iv) mentored application for graduate fellowships, (v) multiple opportunities to attend research conferences, (vi) targeted preparation for a future leadership position in the biomedical sciences, and (vii) mentorship through the transition to a postdoctoral position or other post-graduate employment. Taken together, these training and research activities will enable Ketsia to realize her vision of working at the interface of computational and experimental biophysics, while greatly enhancing her competitiveness for an exciting, independent scientific career in the biomedical sciences.

摘要摘要：促进R35GM139531多样性的行政补充 这项建议是对R35GM139531的行政补充，通过培训 博士后候选人。候选人凯西亚·津加是黑人/非裔美国人，历史上代表不足 在生物科学方面的小组。重要的是，通过这个补充，凯西亚将有机会成为 在实验生物物理学和计算生物物理学的多学科界面上进行培训。凯西亚表达了一种 对这一多学科培训环境的具体愿望，将由两位共同导师促进：(I)教授； 实验生物物理学家珍妮·斯塔科维亚克和(Ii)计算生物物理学家任鹏宇教授。 值得注意的是，如果没有这一行政补充，这种独特的培训机会是不可能的，因为(I) 父母的赠款没有足够的资金，以及(Ii)需要额外的资金来纳入一个重要的 将计算部分融入到项目的现有目标中，这是满足凯西亚独特的 培训目标。拟议补充工作的主要目标完全符合 R35GM139531。具体地说，补充活动支持资助项目的两个主要目标，包括： (一)了解生物膜如何影响蛋白质凝聚体的组装；和(二)了解 蛋白质凝聚体弯曲膜表面能力背后的分子机制。指导原则 这些研究目标，结合凯西亚的职业目标，我们设计了高度量身定制的训练计划 为了凯西亚。我们计划的具体方面包括：(I)由实验和计算研究人员共同指导， (2)设计将实验结果与生物物理模型相结合的研究活动；(3)从 不同的指导委员会，(Iv)与来自不同群体的教职员工互动的机会，(Iv) 有指导的研究生奖学金申请，(V)参加研究会议的多次机会，(Vi) 有针对性地为未来生物医学科学的领导职位做准备，以及(Vii)通过 过渡到博士后职位或其他研究生工作。总而言之，这些培训和 研究活动将使凯西亚能够实现她在计算和计算界面工作的愿景 实验生物物理学，同时大大增强了她对一项令人兴奋的、独立的科学研究的竞争力 从事生物医学科学的职业生涯。