CONNECT-TBI

连接-TBI

• 批准号: 10483198
• 负责人: Douglas Hamilton Smith
• 金额: $ 177.67万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10483198
• 关键词: Acute; Address; Aging; Alzheimer' s Disease; Archives; Attention; Brain; Chronic; Clinical; Clinical Data; Clinical Research; Collaborations; Communities; Complex; Consensus; Data; Data Set; Dementia; Diagnosis; Diagnostic; Enrollment; Exposure to; Future; Health; Human; Injury; Institution; International; Intervention Studies; Late Effects; Lewy Body Disease; Link; Long-Term Survivors; Military Personnel; Nerve Degeneration; Neurodegenerative Disorders; Outcome; Outcome Study; Parkinson Disease; Participant; Pathology; Patients; Phenotype; Prevalence; Process; Prospective Studies; Protocols documentation; Reporting; Research; Research Personnel; Research Support; Resources; Risk; Role; Sampling; Severities; Site; Specimen; Sports; Tissue Donations; Tissue Sample; Tissues; Traumatic Brain Injury; biological specimen archives; brain research; brain tissue; chronic traumatic encephalopathy; contact sports; data resource; experience; inhibitor; mild traumatic brain injury; multidisciplinary; neuropathology; patient population; programs; prospective; success; tissue archive; tissue resource

OVERALL CONNECT-TBI Program Summary In the past several decades, there has been steadily increasing attention to the neuropathological effects of traumatic brain injury (TBI). Intense media attention has focused on the association of repetitive mild TBI with contact sports and have highlighted the risk of neurodegenerative changes including the widely discussed chronic traumatic encephalopathy (CTE). Unfortunately, little is known about the broader process of TBI- Related Neurodegeneration (TRenD) which encompasses a complex spectrum of pathologies induced by TBI, across all mechanisms and severity levels of injury. Arguably the greatest inhibitor of progress in this field is the limited number of suitable human brain tissue samples and their distribution among disparate research and clinical institutions. To overcome this, the proposed center without walls known as COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI) will be comprised of 26 leading expert investigators in TBI from 12 renowned institutions to generate an unparalleled, comprehensive neuropathological and clinical data resource and conduct a comprehensive research effort into the spectrum of pathologies in all types and severities of TBI. Three Cores – Administrative, Brain Bank, and Data Coordinating – will coordinate and support the collation and examination of over 2800 existing TBI case materials and over 7000 samples from patients with related neurodegenerative disorders. Furthermore, CONNECT-TBI will establish tissue donation protocols for ongoing sample enrollment in the coming years. This resource will be utilized to generate a consensus in the operational criteria for the diagnosis of TReNDs across all range and subtypes and to evaluate the extent and distribution of all neuropathologies resulting from TBI exposure. Furthermore, the center will seek to contrast the phenotypes of TReNDs with that of wider neurodegenerative disease and with aging processes. In all, the CONNECT-TBI collaboration will represent a broad, comprehensive exploration of the intricate neuropathological changes following TBI.

整体 CONNECT-TBI计划摘要 在过去的几十年里，人们越来越关注的神经病理学影响， 创伤性脑损伤（TBI）。媒体的强烈关注集中在重复性轻度TBI与 接触性运动，并强调了神经退行性变化的风险，包括广泛讨论的 慢性创伤性脑病（CTE）。不幸的是，对TBI的更广泛过程知之甚少- 相关神经变性（TRenD），其包括由TBI诱导的复杂的病理谱， 所有的损伤机制和严重程度。可以说，这一领域进步的最大阻碍是 合适的人脑组织样本数量有限，而且它们在不同的研究中的分布情况， 临床机构。为了克服这一点，拟议中的中心没有墙壁被称为COllaborative 神经病理学网络表征TBI的结果（CONNECT-TBI）将由26个主要的 来自12个著名机构的TBI专家调查员， 神经病理学和临床数据资源，并进行全面的研究工作到频谱 所有类型和严重程度的TBI的病理学。三个核心-行政、人才库和数据协调 - 将协调和支持对2800多份现有TBI病例材料的整理和审查， 7000份来自相关神经退行性疾病患者的样本。此外，CONNECT-TBI将 为未来几年的持续样本招募建立组织捐赠协议。该资源将 用于在所有范围内就诊断TReND的操作标准达成共识， 亚型，并评估由TBI暴露引起的所有神经病理学的程度和分布。 此外，该中心将寻求将TReND的表型与更广泛的神经退行性疾病的表型进行对比。 疾病和衰老过程。总之，CONNECT-TBI合作将代表一个广泛的， 全面探讨TBI后复杂的神经病理变化。