CONNECT-TBI

总体来说 CONNECT-TBI计划摘要 在过去的几十年里，人们越来越多地关注脑出血的神经病理效应。 创伤性脑损伤(TBI)。媒体的高度关注集中在重复性轻度脑损伤与 接触性运动，并强调了神经退行性变化的风险，包括广泛讨论的 慢性创伤性脑病。不幸的是，人们对TBI更广泛的过程知之甚少- 相关神经变性(趋势)，包括由脑损伤引起的一系列复杂的病理变化， 所有伤害的机制和严重程度。可以说，这一领域取得进展的最大阻碍是 有限的合适的人脑组织样本及其在不同研究和研究中的分布 临床机构。为了克服这一点，拟议中的无墙中心被称为协作中心 表征脑损伤(CONNECT-TBI)结果的神经病理网络将由26个主要成员组成 来自12家知名机构的专家调查员在TBI中产生了无与伦比的、全面的 神经病理学和临床数据资源，并进行全面的研究工作 各种类型和严重程度的颅脑损伤的病理改变。三个核心-管理、智库和数据协调 -将协调和支持对2800多份现有的TBI案件材料的整理和审查 7000份来自相关神经退行性疾病患者的样本。此外，CONNECT-TBI将 建立组织捐赠协议，以便在未来几年进行样本登记。这一资源将是 用于在所有范围内的趋势诊断的操作标准中产生共识 并评估由脑创伤暴露引起的所有神经病理的程度和分布。 此外，该中心将寻求将趋势的表型与更广泛的神经退行性变的表型进行对比 疾病和衰老过程。总而言之，CONNECT-TBI协作将代表广泛的、 全面探讨脑外伤后错综复杂的神经病理变化。

OVERALL CONNECT-TBI Program Summary In the past several decades, there has been steadily increasing attention to the neuropathological effects of traumatic brain injury (TBI). Intense media attention has focused on the association of repetitive mild TBI with contact sports and have highlighted the risk of neurodegenerative changes including the widely discussed chronic traumatic encephalopathy (CTE). Unfortunately, little is known about the broader process of TBI- Related Neurodegeneration (TRenD) which encompasses a complex spectrum of pathologies induced by TBI, across all mechanisms and severity levels of injury. Arguably the greatest inhibitor of progress in this field is the limited number of suitable human brain tissue samples and their distribution among disparate research and clinical institutions. To overcome this, the proposed center without walls known as COllaborative Neuropathology NEtwork Characterizing ouTcomes of TBI (CONNECT-TBI) will be comprised of 26 leading expert investigators in TBI from 12 renowned institutions to generate an unparalleled, comprehensive neuropathological and clinical data resource and conduct a comprehensive research effort into the spectrum of pathologies in all types and severities of TBI. Three Cores – Administrative, Brain Bank, and Data Coordinating – will coordinate and support the collation and examination of over 2800 existing TBI case materials and over 7000 samples from patients with related neurodegenerative disorders. Furthermore, CONNECT-TBI will establish tissue donation protocols for ongoing sample enrollment in the coming years. This resource will be utilized to generate a consensus in the operational criteria for the diagnosis of TReNDs across all range and subtypes and to evaluate the extent and distribution of all neuropathologies resulting from TBI exposure. Furthermore, the center will seek to contrast the phenotypes of TReNDs with that of wider neurodegenerative disease and with aging processes. In all, the CONNECT-TBI collaboration will represent a broad, comprehensive exploration of the intricate neuropathological changes following TBI.