Contrast cTBI neuropathology to that of aging and wider neurodegenerative diseases

将 cTBI 神经病理学与衰老和更广泛的神经退行性疾病进行对比

• 批准号: 10241895
• 负责人: Douglas Hamilton Smith
• 金额: $ 9.02万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10241895
• 关键词: Admixture; Aging; Alzheimer' s Disease; Amyloid; Amyloid beta-Protein; Attention; Autopsy; Case Study; Characteristics; Chronic; Clinical; Cohort Studies; Complex; Consensus; Elements; Exposure to; Frontotemporal Lobar Degenerations; Goals; Heterogeneity; High Prevalence; Lesion; Lewy Body Disease; Link; Measurable; Methods; Nerve Degeneration; Neurocognitive; Neurodegenerative Disorders; Outcome; Pathology; Patients; Prevalence; Process; Recording of previous events; Reporting; Research Personnel; Research Project Grants; Risk; Standardization; Survivors; Syndrome; TBI Patients; TDP-43 aggregation; Techniques; Testing; Traumatic Brain Injury; aged; alpha synuclein; chronic traumatic encephalopathy; cohort; comorbidity; comparative; nervous system disorder; neuropathology; neuropsychiatry; tau Proteins

Research Project 2 SUMMARY There is growing concern over the association between traumatic brain injury (TBI) and progressive neurodegenerative changes, in particular those described as chronic traumatic encephalopathy (CTE). First recognized in boxers, it was not until later reports of similar pathologies in non-boxer athletes that the long-term consequences of TBI attracted widespread attention. Recent and preliminary consensus criteria propose CTE as a distinct neurodegenerative pathology, although the associated clinical consequences of this pathology remain unclear. Importantly, there is growing consensus that there is a high prevalence of comorbidity across neurodegenerative diseases including AD, Lewy body disease, and frontotemporal lobar degeneration. While, current reporting in CTE largely focuses on proposed “pathognomonic” tau pathologies, the heterogeneity of neurodegenerative disease neuropathology associated with chronic survival from TBI (cTBI) is not well described. Here we will evaluate the spectrum of neuropathologic change that is shared or unique between TBI- related neurodegeneration (TReND) versus other neurodegenerative diseases including Alzheimer’s disease (AD), Lewy body disease, and frontotemporal lobar degeneration. Specifically, by evaluating a neurodegenerative disease autopsy cohort of 275 cases, matched to the cTBI cohort studied in research project 1, we will examine for the presence and distribution of neuropathologies including Aβ amyloid, tau, α-synuclein and TDP-43 aggregates. Importantly, by examining a further cohort of 450 cases, we will also determine whether TReND pathology, like other neurodegenerative disease processes, can also be observed in neurodegenerative disease cases without any history of TBI.

研究项目2