Contrast cTBI neuropathology to that of aging and wider neurodegenerative diseases

研究项目2 总结 越来越多的人关注创伤性脑损伤（TBI）和进行性脑损伤之间的关系。 神经退行性变化，特别是被描述为慢性创伤性脑病（CTE）的那些。第一 在拳击运动员中被认识到，直到后来报道非拳击运动员的类似病理， TBI的后果引起了广泛关注。最新和初步共识标准建议CTE 作为一种独特的神经退行性病变，尽管这种病变的相关临床后果 仍然不清楚。重要的是，越来越多的共识是，在所有年龄组中， 神经变性疾病，包括AD、路易体病和额颞叶变性。同时， 目前CTE的报道主要集中在提出的“特异性”tau病理， 与TBI慢性存活相关的神经退行性疾病神经病理学（cTBI） 介绍了在这里，我们将评估TBI之间共享或独特的神经病理学变化谱- 相关神经退行性疾病（TReND）与包括阿尔茨海默病在内的其他神经退行性疾病 (AD)Lewy小体病和额颞叶变性。具体而言，通过评估A 275例神经退行性疾病尸检队列，与研究项目中研究的cTBI队列相匹配 1，我们将检查神经病理的存在和分布，包括Aβ淀粉样蛋白，tau蛋白，α-突触核蛋白， 和TDP-43聚集体。重要的是，通过进一步研究450例病例，我们还将确定 与其他神经退行性疾病过程一样，TReND病理也可以在神经退行性疾病中观察到。 无任何TBI病史的病例。

Research Project 2 SUMMARY There is growing concern over the association between traumatic brain injury (TBI) and progressive neurodegenerative changes, in particular those described as chronic traumatic encephalopathy (CTE). First recognized in boxers, it was not until later reports of similar pathologies in non-boxer athletes that the long-term consequences of TBI attracted widespread attention. Recent and preliminary consensus criteria propose CTE as a distinct neurodegenerative pathology, although the associated clinical consequences of this pathology remain unclear. Importantly, there is growing consensus that there is a high prevalence of comorbidity across neurodegenerative diseases including AD, Lewy body disease, and frontotemporal lobar degeneration. While, current reporting in CTE largely focuses on proposed “pathognomonic” tau pathologies, the heterogeneity of neurodegenerative disease neuropathology associated with chronic survival from TBI (cTBI) is not well described. Here we will evaluate the spectrum of neuropathologic change that is shared or unique between TBI- related neurodegeneration (TReND) versus other neurodegenerative diseases including Alzheimer’s disease (AD), Lewy body disease, and frontotemporal lobar degeneration. Specifically, by evaluating a neurodegenerative disease autopsy cohort of 275 cases, matched to the cTBI cohort studied in research project 1, we will examine for the presence and distribution of neuropathologies including Aβ amyloid, tau, α-synuclein and TDP-43 aggregates. Importantly, by examining a further cohort of 450 cases, we will also determine whether TReND pathology, like other neurodegenerative disease processes, can also be observed in neurodegenerative disease cases without any history of TBI.