Institute for Integration of Medicine & Science: A Partnership to Improve Health

医学整合研究所

• 批准号: 10487947
• 负责人: ROBERT A CLARK
• 金额: $ 1.74万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-28 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10487947
• 关键词: Area; Cities; Clinical Research; Clinical Sciences; Clinical Trials; Communities; Complex; County; Development; Diabetes Mellitus; Doctor of Philosophy; Effectiveness; Electronic Health Record; Fostering; Grant; Health; Health Insurance; Health Sciences; Health Services Accessibility; Healthcare Systems; Hispanic Populations; Home; Informatics; Institutes; Institution; Institutional Review Boards; Investments; Knowledge; Learning; Malignant Neoplasms; Master' s Degree; Medical; Medicine; Methods; Military Personnel; Minority; Obesity; Pathway interactions; Population; Population Heterogeneity; Positioning Attribute; Poverty; Process; Program Development; Research; Research Personnel; Research Priority; Resources; Rural; Rural Population; Science; Services; South Texas; Students; TNFSF15 gene; Time; Training; Translating; Translational Research; Veterans; Vision; Workforce Development; active duty; biomedical scientist; care delivery; care outcomes; cost; data warehouse; disparity reduction; health disparity; improved; innovation; metropolitan; military veteran; practice-based research network; programs; service member; success; translational scientist

Overall-Abstract San Antonio, positioned at the gateway to South Texas, is the 7th largest US city and the largest metropolitan area with a minority-majority population. Our 38-county region comprises an impoverished, rural, and largely Hispanic population with disproportionate rates of diabetes, obesity, and cancer, exacerbated by lack of health insurance and poor access to care. The region is home to major US military facilities, including the world’s largest military medical complex. Service members and veterans form populations with special needs. Neither better access to care nor improved care delivery, on their own, can eliminate health disparities. Innovative translational research is required to fill knowledge gaps and establish real-world effectiveness to improve health. In 2006, UT Health Science Center-San Antonio established the Institute for Integration of Medicine & Science (IIMS) as the academic home for our growing translational science initiatives, training the translational science workforce, formalizing key strategic partnerships, and creating a community of scholars within a learning healthcare system. We expanded clinical research programs, dramatically increasing access to clinical trials. We developed 6 Practice-Based Research Networks that focus on diverse ambulatory populations. We created 6 county-wide Translational Advisory Boards that support engagement through priority setting and matching with academic investigators. IIMS pioneered IRB process harmonization, resulting in rapid review times and streamlined pathways to multisite study initiation. We operate a robust pilot grant program, leveraged among our partners, with a remarkable return on investment. Our workforce development programs, with matriculants reflecting our diverse population, have graduated 133 masters degree students, supported 27 successful KL2 Scholars and 16 TL1 Scholars, and established de novo a Translational Science PhD program. Our informatics team has led electronic health record data warehouse development, fostering matches between IIMS investigators and practice-relevant research priorities. IIMS is now poised to deploy our robust portfolio of programs across our growing, leveraged, and innovative network of institutional and community partners. In this proposal, we provide clear strategies to support clinical and translational science across partner organizations, catalyze research team success, and implement programs that produce creative, collaborative, and culturally diverse translational scientists. IIMS seeks exceptionalism in translating scientific discoveries across the T1 to T4 spectrum into improved health care outcomes. Our over-arching Specific Aims are: 1. Accelerate clinical and translational research innovation and team science along the entire T1 to T4 research spectrum by providing an academic home integrated with our strategic partner institutions 2. Expand, diversify, and enhance the workforce of interdisciplinary translational biomedical scientists 3. Implement effective methods to continuously evaluate and optimize services, increase efficiencies, improve processes, endorse common metrics, and reduce costs across all IIMS programs

整体-摘要 圣安东尼奥位于南得克萨斯州的门户，是美国第七大城市，也是美国 人口以少数族裔为主的最大的大都市区。我们38个县的地区包括一个贫困的， 农村人口，主要是西班牙裔人口，糖尿病、肥胖症和癌症的比例不成比例，加剧了 由于缺乏医疗保险和获得保健的机会很少。该地区是美国主要军事设施的所在地，包括 世界上最大的军事医疗综合体。服役人员和退伍军人形成了有特殊需求的人群。 更好地获得护理或改善护理提供本身都不能消除健康差距。创新型 需要进行转化研究，以填补知识空白，并建立改善健康的现实世界有效性。 2006年，德克萨斯大学圣安东尼奥分校健康科学中心成立了医学与科学一体化研究所。 科学(IIMs)作为我们日益增长的翻译科学倡议的学术之家，培训翻译人员 科学劳动力，正式确定关键的战略合作伙伴关系，并在一次学习中创建一个学者社区 医疗保健系统。我们扩大了临床研究项目，极大地增加了临床试验的机会。 我们开发了6个以实践为基础的研究网络，专注于不同的流动人口。我们创造了 6个县范围内的翻译咨询委员会，通过设定优先事项并与 学术研究人员。IIMS开创了IRB流程协调的先河，从而缩短了审查时间，并 简化了多站点研究启动的途径。我们运营着一个强大的试点赠款计划，在我们的 合作伙伴，具有显著的投资回报。我们的劳动力发展计划，包括预科学生 反映了我们人口的多样性，已有133名硕士研究生毕业，支持了27名成功的KL2 学者和16名TL1学者，并建立了一个新的翻译科学博士项目。我们的信息学 团队领导了电子健康记录数据仓库的开发，促进了IIM之间的匹配 调查人员和与实践相关的研究优先事项。IIMS现在准备部署我们强大的 我们的机构和社区合作伙伴不断增长、充分利用和创新的网络中的各种计划。 在这份计划书中，我们提供了明确的战略，以支持合作伙伴之间的临床和翻译科学 组织，促进研究团队的成功，并实施产生创造性、协作性、 以及不同文化背景的翻译科学家。IIMS在翻译科学发现时寻求例外主义 跨越T1到T4频谱，从而改善医疗保健结果。我们总体的具体目标是： 1.加快从T1到T4的临床和转化性研究创新和团队科学 通过提供与我们的战略合作伙伴机构集成的学术之家来研究光谱 2.扩大、多样化和提高跨学科转化型生物医学科学家的队伍 3.落实有效方法，持续评估和优化服务，提高效率， 改进流程，认可通用指标，并降低所有IIM项目的成本

项目成果

Social Support and the Rehabilitation of Alcohol-Impaired Drivers: Drinking Motives as Moderators.

社会支持和酒后驾车者的康复：饮酒动机作为调节者。

• DOI: 10.1080/10410236.2020.1731914
• 发表时间: 2021
• 期刊: Health communication
• 影响因子: 3.9
• 作者: Moon,Tae-Joon;Mathias,CharlesW;Mullen,Jillian;Karns-Wright,TaraE;Hill-Kapturczak,Nathalie;Roache,JohnD;Dougherty,DonaldM
• 通讯作者: Dougherty,DonaldM

Development of a Mobile Application to Enhance Knowledge, Awareness and Communication of Dry Mouth Amongst Dental Practitioners and Patients: A South Texas Oral Health Network Study.

开发移动应用程序以增强牙科医生和患者对口干症的知识、意识和沟通：南德克萨斯州口腔健康网络研究。

• 发表时间: 2021
• 期刊: Texas dental journal
• 作者: Mungia,Rahma;Mendoza,Marissa;delaRosa,Elisabeth;Nguyen,Thi;Reyes,StephanieC;Schramm,Danielle;Taverna,Melanie
• 通讯作者: Taverna,Melanie

Kynurenine pathway metabolic balance influences microglia activity: Targeting kynurenine monooxygenase to dampen neuroinflammation.

Kynurenine途径代谢平衡会影响小胶质细胞活性：靶向Kynurenine单加氧酶降低神经炎症。

• DOI: 10.1016/j.psyneuen.2018.04.019
• 发表时间: 2018-08
• 期刊: Psychoneuroendocrinology
• 影响因子: 3.7
• 作者: Garrison AM;Parrott JM;Tuñon A;Delgado J;Redus L;O'Connor JC
• 通讯作者: O'Connor JC

Further evidence supporting a potential role for ADH1B in obesity.

• DOI: 10.1038/s41598-020-80563-z
• 发表时间: 2021-01-21
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Morales LD;Cromack DT;Tripathy D;Fourcaudot M;Kumar S;Curran JE;Carless M;Göring HHH;Hu SL;Lopez-Alvarenga JC;Garske KM;Pajukanta P;Small KS;Glastonbury CA;Das SK;Langefeld C;Hanson RL;Hsueh WC;Norton L;Arya R;Mummidi S;Blangero J;DeFronzo RA;Duggirala R;Jenkinson CP
• 通讯作者: Jenkinson CP

Health Equity in Patients Receiving Durvalumab for Unresectable Stage III Non-Small Cell Lung Cancer in the US Veterans Health Administration.

• DOI: 10.1093/oncolo/oyad172
• 发表时间: 2023-09-07
• 期刊: The oncologist