Institute for Integration of Medicine & Science: A Partnership to Improve Health

总体摘要 圣安东尼奥位于德克萨斯州南部的门户，是美国第七大城市，也是美国第七大城市 少数民族人口占多数的最大都市区。我们的38个县包括贫困、 农村人口（主要是西班牙裔人口）的糖尿病、肥胖症和癌症发病率不成比例，加剧了 由于缺乏健康保险和难以获得护理。该地区是美国主要军事设施的所在地，包括 世界上最大的军事医疗综合体。服役人员和退伍军人构成了有特殊需求的人群。 更好地获得医疗服务或改善医疗服务本身都无法消除健康差距。创新 需要进行转化研究来填补知识空白并建立现实世界的有效性以改善健康。 2006年，UT健康科学中心-圣安东尼奥建立了医学与医学整合研究所 科学（IIMS）作为我们不断发展的转化科学计划的学术家园，培训转化科学 科学劳动力，正式建立关键战略伙伴关系，并在学习中创建学者社区 医疗保健系统。我们扩大了临床研究项目，极大地增加了临床试验的机会。 我们开发了 6 个基于实践的研究网络，重点关注不同的流动人群。我们创造了 6 个全县范围内的翻译咨询委员会，通过优先事项设定和匹配来支持参与 学术研究者。 IIMS 率先实现了 IRB 流程协调，从而缩短了审核时间并 简化多地点研究启动途径。我们实施强有力的试点拨款计划，充分利用我们的 合作伙伴，具有显着的投资回报。我们的劳动力发展计划，包括预科生 反映了我们多元化的人口，已毕业 133 名硕士学位学生，支持 27 名成功的 KL2 学者和 16 名 TL1 学者，并从头建立了转化科学博士项目。我们的信息学 团队领导了电子健康记录数据仓库的开发，促进了 IIMS 之间的匹配 研究人员和实践相关的研究重点。 IIMS 现在准备部署我们强大的产品组合 我们不断发展的、杠杆化的、创新的机构和社区合作伙伴网络中的项目。 在此提案中，我们提供了明确的策略来支持合作伙伴之间的临床和转化科学 组织，促进研究团队的成功，并实施能够产生创造性、协作性、 和文化多元化的转化科学家。 IIMS 寻求转化科学发现的例外主义 从 T1 到 T4 范围，改善医疗保健结果。我们的总体具体目标是： 1. 沿着整个T1到T4加速临床和转化研究创新和团队科学 通过提供与我们的战略合作伙伴机构整合的学术家园来研究范围 2. 扩大、多样化和增强跨学科转化生物医学科学家的队伍 3.实施有效的方法来持续评估和优化服务，提高效率， 改进流程、认可通用指标并降低所有 IIMS 计划的成本

Overall-Abstract San Antonio, positioned at the gateway to South Texas, is the 7th largest US city and the largest metropolitan area with a minority-majority population. Our 38-county region comprises an impoverished, rural, and largely Hispanic population with disproportionate rates of diabetes, obesity, and cancer, exacerbated by lack of health insurance and poor access to care. The region is home to major US military facilities, including the world’s largest military medical complex. Service members and veterans form populations with special needs. Neither better access to care nor improved care delivery, on their own, can eliminate health disparities. Innovative translational research is required to fill knowledge gaps and establish real-world effectiveness to improve health. In 2006, UT Health Science Center-San Antonio established the Institute for Integration of Medicine & Science (IIMS) as the academic home for our growing translational science initiatives, training the translational science workforce, formalizing key strategic partnerships, and creating a community of scholars within a learning healthcare system. We expanded clinical research programs, dramatically increasing access to clinical trials. We developed 6 Practice-Based Research Networks that focus on diverse ambulatory populations. We created 6 county-wide Translational Advisory Boards that support engagement through priority setting and matching with academic investigators. IIMS pioneered IRB process harmonization, resulting in rapid review times and streamlined pathways to multisite study initiation. We operate a robust pilot grant program, leveraged among our partners, with a remarkable return on investment. Our workforce development programs, with matriculants reflecting our diverse population, have graduated 133 masters degree students, supported 27 successful KL2 Scholars and 16 TL1 Scholars, and established de novo a Translational Science PhD program. Our informatics team has led electronic health record data warehouse development, fostering matches between IIMS investigators and practice-relevant research priorities. IIMS is now poised to deploy our robust portfolio of programs across our growing, leveraged, and innovative network of institutional and community partners. In this proposal, we provide clear strategies to support clinical and translational science across partner organizations, catalyze research team success, and implement programs that produce creative, collaborative, and culturally diverse translational scientists. IIMS seeks exceptionalism in translating scientific discoveries across the T1 to T4 spectrum into improved health care outcomes. Our over-arching Specific Aims are: 1. Accelerate clinical and translational research innovation and team science along the entire T1 to T4 research spectrum by providing an academic home integrated with our strategic partner institutions 2. Expand, diversify, and enhance the workforce of interdisciplinary translational biomedical scientists 3. Implement effective methods to continuously evaluate and optimize services, increase efficiencies, improve processes, endorse common metrics, and reduce costs across all IIMS programs