Pilot and Exploratory Studies Core (PESC)

试点和探索性研究核心（PESC）

• 批准号: 10455766
• 负责人: ROBERT A CLARK
• 金额: $ 21.93万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-06-15 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10455766
• 关键词: Address; Aging; American; Animal Model; Area; Behavior Therapy; Biology of Aging; Callithrix; Capsicum; Cells; Clinical Pharmacology; Clinical Research; Clinical Trials; Communities; Disease; Dissemination and Implementation; Doctor of Philosophy; Ensure; Environment; Faculty; Financial Support; Funding; Geroscience; Goals; Grant; Health Sciences; Homeostasis; Human; Infrastructure; Institutes; Interdisciplinary Study; Intervention; Investments; Knowledge; Laboratories; Lead; Life Expectancy; Literature; Longevity; Medicine; Mentors; Methods; Modeling; Monitor; NCI-Designated Cancer Center; Pharmacology; Phase; Phase I Clinical Trials; Pilot Projects; Play; Positioning Attribute; Primates; Process; Publications; Research; Research Personnel; Resources; Science; Shock; Stress; Technology; Testing; Texas; Thinking; Training; Translating; Translational Research; Translations; Universities; Work; age related; base; bench to bedside; design; education research; effective intervention; efficacy testing; experience; healthspan; healthy aging; innovation; knowledge base; medical schools; meetings; nonhuman primate; novel; pre-clinical; pre-clinical research; preclinical study; programs; resilience; side effect; stem cell gene therapy; therapy design; translational scientist; translational study

In recent years, major advances have been made in our understanding of the basic biology of aging, leading to the identification of novel interventions with potential to prolong healthspan. In spite of exciting studies in model organisms, there has been a lack of programs and infrastructure needed to enable the translation of these discoveries to humans. The major objective of the Pilot / Exploratory Studies Core (PESC) is to promote the overarching goals of the San Antonio Older Americans Independence Center (OAIC) by developing and validating interventions to enhance healthy aging and mitigate the progression of aging-associated processes and diseases. Indeed, the PESC plays a key role in the San Antonio OAIC's central theme of translational geroscience by supporting projects that move research on the basic biology of aging from the laboratory bench to the bedside, in order to extend healthy life expectancy. The PESC will provide merit-based support for rigorously designed pilot studies that test both the efficacy and side effect profiles of promising pharmacologic, as well as non-pharmacologic cell-based and behavioral interventions, in pre-clinical marmoset models and early human clinical studies. The PESC will strive to achieve its objectives through the following specific aims: • Aim 1: To promote innovative, collaborative, multidisciplinary research to test interventions designed to extend healthy life expectancy, both in early human trials and in non-human primate marmoset models. • Aim 2: To work closely with the Resource Cores and Research Education Component to provide infrastructure, scientific support, and funding for innovative pilot proposals from mentored junior faculty investigators, as well as established researchers. • Aim 3: To encourage pilot studies that will develop and apply novel methods and technologies. • Aim 4: To sustain effective processes to solicit, review, and fund pilot projects, as well as ensure study completion, robust tracking of downstream impact, and optimal dissemination and implementation. The Core leaders, having a great deal of experience directing successful pilot project programs, will promote key alignments and interactions of PESC investigators with OAIC Resource Cores, as well as with resources in the broader scientific community. The Core will provide close oversight and guidance to PESC-supported studies from inception, during the investigative and analytical phases, through publication, and ultimately through the submission of proposals for competitive national grant funding. The PESC will seek proposals on rapidly evolving age-related scientific areas such as resilience – the capacity to return to normal functional homeostasis after stress exposure. To address the shrinking pipeline of qualified translational investigators the PESC is committed to funding meritorious proposals from early-stage investigators. Finally, we have received significant leveraging commitments, enabling PESC project investments of $290K annually and positioning the PESC to achieve both a robust return on investment and significant impact on translational geroscience.

近年来，我们对衰老的基本生物学的理解取得了重大进展， 确定有可能延长健康寿命的新干预措施。尽管有令人兴奋的研究， 模式生物，一直缺乏程序和基础设施，需要使这些翻译 人类的发现。试点/探索性研究核心（PESC）的主要目标是促进 圣安东尼奥老年美国人独立中心（OAIC）的总体目标， 验证干预措施，以促进健康老龄化和减缓与老龄化相关的进程的进展 和疾病。事实上，PESC在圣安东尼奥OAIC的翻译中心主题中发挥着关键作用。 通过支持将衰老的基础生物学研究从实验室工作台转移到老年科学的项目 为了延长健康的预期寿命PESC将提供基于绩效的支持， 严格设计的试点研究，测试有前途的药理学， 以及非药理学细胞和行为干预，在临床前绒猴模型和早期 人体临床研究。PESC将通过以下具体目标努力实现其目标： ·目标1：促进创新、协作和多学科研究，以测试旨在 延长健康的预期寿命，无论是在早期的人体试验和非人类灵长类绒猴模型。 ·目标2：与资源核心和研究教育部分密切合作， 基础设施，科学支持，以及为指导的初级教师的创新试点提案提供资金 调查人员，以及已建立的研究人员。 目标3：鼓励开展试点研究，开发和应用新的方法和技术。 ·目标4：维持有效的程序，征求、审查和资助试点项目，并确保研究 完成、对下游影响的有力跟踪以及最佳传播和实施。 核心领导人，具有丰富的经验，指导成功的试点项目计划，将促进 PESC调查人员与OAIC资源核心以及 更广泛的科学界。核心委员会将为PESC支持的研究提供密切监督和指导 从一开始，在调查和分析阶段，通过出版，并最终通过 提交竞争性国家赠款供资提案。PESC将寻求快速发展的建议 与年龄相关的科学领域，如恢复力-恢复正常功能稳态的能力， 压力暴露为了解决合格的翻译研究人员不断减少的问题，PESC致力于 到资助早期调查人员的有价值的建议。最后，我们获得了巨大的杠杆作用 承诺，使PESC项目每年投资29万美元，并定位PESC实现这两个目标 强劲的投资回报和对转化老年科学的重大影响。