Enhancing Children's Cognitive Function and Achievement through Carotenoid Consumption

通过摄入类胡萝卜素增强儿童的认知功能和成绩

• 批准号: 10488167
• 负责人: Naiman Khan
• 金额: $ 56.65万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-17 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488167
• 关键词: 10 year old; Academic achievement; Achievement; Antioxidants; Attention; Brain; Carotenoids; Child; Child Nutrition; Childhood; Cognition; Cognitive; Collaborations; Consumption; Control Groups; Data; Data Set; Diet; Dietary Carotenoid; Dietary Practices; Double-Blind Method; Event; Exhibits; Eye; Food; Health; Health Promotion; Hippocampus (Brain); Human; Intake; Intervention; Isomerism; Knowledge; Laboratories; Learning; Link; Longevity; Lutein; Measures; Mediating; Membrane; Memory; Mission; Neuraxis; Neurocognitive; Nutrient; Nutritional; Optics; Outcome; Parents; Pattern; Performance; Pigments; Placebo Control; Plants; Policy Maker; Positioning Attribute; Publishing; Randomized; Reaction Time; Recommendation; Recording of previous events; Research; Resource Allocation; Retina; Role; Schools; Supplementation; Surrogate Markers; Task Performances; Testing; Time; Tissues; United States; United States National Institutes of Health; Vegetables; Waiting Lists; Work; cognitive benefits; cognitive control; cognitive development; cognitive function; density; design; dietary guidelines; double-blind placebo controlled trial; evidence base; evidence based guidelines; executive function; improved; indexing; information processing; innovation; insight; learning ability; macula; novel; nutrition; nutritional approach; placebo group; preadolescence; primary outcome; processing speed; reconstruction; relating to nervous system; relational memory; secondary outcome; success; teacher; zeaxanthin

Project Abstract Adequate diet quality has the potential to promote childhood cognitive health and have a lasting impact on children’s ability for learning and achievement. My laboratory has identified that lutein, a plant pigment or carotenoid found in rich quantities in dark green vegetables, is uniquely suitable for supporting childhood cognition and achievement. Lutein is the predominant carotenoid in neural tissue, serving roles as an antioxidant across neural membranes. Further, lutein, along with two other carotenoids (i.e., zeaxanthin and mesozeaxanthin) accumulate in the macular as macular pigment, which is known to strongly correlate with brain lutein. My work has linked macular pigment optical density (MPOD) – a noninvasive measure of retinal and brain lutein – to greater childhood cognitive function. However, the cognitive implications of lutein and zeaxanthin intake in children have not been directly investigated. This proposal aims to establish a causal relationship between lutein intake, cognitive function, and academic performance. The central hypothesis is that lutein consumption will benefit cognitive function and academic achievement in preadolescents. I also anticipate that gains in cognitive outcomes will be mediated by the improvement in MPOD. These hypotheses will be tested by conducting a randomized placebo-controlled double-blind trial to examine the effects of 9-month carotenoid supplementation on MPOD, cognition (attention and memory), and achievement among 8-10-year-old children (N=288, 144/group). The active supplement will comprise of 10mg lutein + 2mg zeaxanthin. This work will provide the evidence-base for recommendations to improve dietary practices for optimal childhood cognitive function and achievement. The proposed research is relevant to human health and the NIH mission because it will provide novel data supporting evidence-based recommendations to improve dietary practices for optimal cognitive function and achievement in childhood.

项目摘要 适当的饮食质量有可能促进儿童的认知健康，并对 儿童的学习能力和成就。我的实验室已经确定了叶黄素，一种植物色素或 类胡萝卜素在深绿色蔬菜中含量丰富，特别适合儿童成长。 认知和成就。叶黄素是神经组织中主要的类胡萝卜素，起着抗氧化剂的作用。 穿过神经膜。此外，叶黄素和另外两种类胡萝卜素(即玉米黄质和玉米黄质) 中玉米黄质)在黄斑中以黄斑色素的形式积累，已知这种色素与大脑密切相关 叶黄素。我的工作将黄斑色素光密度(MPOD)与视网膜和大脑的非侵入性测量联系在一起 叶黄素--增强儿童的认知功能。然而，叶黄素和玉米黄质的认知意义 尚未对儿童的摄入量进行直接调查。这项提议旨在建立一种因果关系 叶黄素摄入量、认知功能和学习成绩之间的关系。中心假设是叶黄素 消费有利于青春期前儿童的认知功能和学习成绩。我也期待着 认知结果的提高将受到MPOD改善的影响。这些假设将通过以下方式进行验证 进行一项随机、安慰剂对照的双盲试验，以检查9个月类胡萝卜素的效果 对8-10岁儿童的MPOD、认知(注意力和记忆)和成就的补充 (n=288,144个/组)。活性补充剂由10毫克叶黄素+2毫克玉米黄质组成。这项工作将提供 改善饮食习惯以优化儿童认知功能的建议的证据基础 和成就。拟议的研究与人类健康和美国国立卫生研究院的任务有关，因为它将提供 支持循证建议的新数据，以改善饮食习惯以实现最佳认知 儿童时期的功能和成就。