Chicago Center on Musculoskeletal Pain (C-COMP) (Overall Application)

项目摘要 我们寻求建立一个新的以资源为基础的中心，以促进和支持研究和培训， 了解与肌肉骨骼（MSK）和风湿性疾病相关的疼痛机制， 最终目标是更好地管理和预防。世界上三分之一的人口受到 慢性疼痛，并且MSK系统是疼痛和残疾的最普遍来源。当前可用 镇痛药物作用于有限数量的靶点，并且它们不提供持续的疼痛缓解， 使用与严重的副作用有关。确定安全有效的药物的主要障碍 产生疼痛缓解的药物是我们普遍缺乏对MSK疼痛机制的了解， 这些机制如何在不同类型的风湿性和MSK疾病之间重叠或不同。的 芝加哥肌肉骨骼疼痛中心（C-COMP）将以及时和独特的方式满足这一需求， 利用世界一流的专业知识，是提供给我们在MSK研究，疼痛和 神经生物学，以实现以下广泛的长期目标：（1）整合基础，转化和临床 多学科中心的专业知识，将为促进MSK疼痛提供领导和资源 研究;（2）通过提供以下途径，改善MSK研究界的研究环境： 世界一流的专业知识和最先进的资源，技术和基础设施，用于研究疼痛;（3） 促进MSK研究领域与疼痛/神经科学领域之间的跨学科研究;（4） 通过吸引早期职业以及建立研究人员进入这一领域，扩大MSK疼痛研究社区 研究领域。我们设想三个核心运作，以支持这些总体目标。行政核心A (PI：A.M. Malfait;联合主任：J. J. Jacobs）将提供领导，保持有效的沟通，与 相关中心，以刺激人类翻译的结果，并实施一个动态的丰富计划。的 行为资源核心B（PI：R.E.作者：米勒; Sumner）将提供集中资源， 促进广泛的风湿性和MSK疾病动物模型中的行为测定，包括训练 对于行为测试，访问定制的协议，设备和空间来执行测试，咨询 服务和定制的全方位服务选项，用于行为测试。神经生物学核心C（PI：RJ米勒;合作， 导演：D.R. Sumner）将提供最先进的技术来评估和操纵神经元回路 参与疼痛生理学，如体内钙成像，电生理学，化学/光遗传学， 转录组学/生物信息学和神经解剖学技术。这将使该中心的研究界 从事MSK疾病动物模型疼痛机制的前沿研究。在 总而言之，C-COMP将提供（1）独特的资源和基础设施，以支持高质量的外部 资助的研究和（2）试点资金，教育和培训，在多学科和合作的方式。 这种综合方法有望加速与MSK和风湿性疾病相关的疼痛研究。

Project summary We seek to establish a new resource-based Center to foster and support research and training aimed at understanding the mechanisms underlying pain associated with musculoskeletal (MSK) and rheumatic diseases, with the ultimate goal of better managing and preventing it. One third of the world’s population is affected by chronic pain, and the MSK system is the most prevalent source of pain and disability. Currently available analgesic drugs act on a limited number of targets, and they do not provide sustained pain relief and their chronic use is associated with serious adverse effects. One of the major obstacles in identifying safe and efficacious drugs for producing pain relief is our general lack of understanding of the mechanisms underlying MSK pain, and how these mechanisms may overlap or differ between different types of rheumatic and MSK diseases. The Chicago Center on Musculoskeletal Pain (C-COMP) will address this need in a timely and unique manner, capitalizing on the world class expertise that is available to us in the areas of MSK research, pain and neurobiology to achieve the following broad long-term goals: (1) To integrate basic, translational and clinical expertise in a multidisciplinary Center which will provide the leadership and resources for promoting MSK pain research; (2) To enhance the research environment for the MSK research community by providing access to world-class expertise and state-of-the-art resources, technologies, and infrastructure for studying pain; (3) To promote interdisciplinary research between the MSK research field and the field of pain/neuroscience; (4) To expand the MSK pain research community by attracting early career as well as established researchers into this area of study. We envision three Cores operating in support of these overall goals. The Administrative Core A (PI: A.M. Malfait; co-director: J.J. Jacobs) will provide leadership, maintain effective communication, partner with related Centers to stimulate human translation of findings, and implement a dynamic enrichment program. The Behavioral Resource Core B (PI: R.E. Miller; co-director: D.R. Sumner) will provide a centralized resource to facilitate behavioral assays in a broad array of animal models of rheumatic and MSK diseases, including training for behavioral tests, access to customized protocols, equipment, and space to perform testing, a consultation service and a customized, full-service option for behavioral testing. The Neurobiology Core C (PI: RJ Miller; co- director: D.R. Sumner) will offer state-of-the-art techniques for assessment and manipulation of neuronal circuitry involved in pain physiology, such as in vivo calcium imaging, electrophysiology, chemo/optogenetics, transcriptomics/bioinformatics and neuroanatomical techniques. This will allow the Center’s research community to engage in cutting-edge investigations of the mechanisms of pain in animal models of MSK disease. In summary, C-COMP will provide (1) unique resources and infrastructure for supporting high-quality externally funded research and (2) pilot funding, education, and training in a multidisciplinary and collaborative fashion. This integrated approach is expected to accelerate research in pain associated with MSK and rheumatic disease.