Chicago Center on Musculoskeletal Pain (C-COMP) (Overall Application)

芝加哥肌肉骨骼疼痛中心 (C-COMP)（整体申请）

• 批准号: 10676988
• 负责人: Anne-Marie Malfait
• 金额: $ 76.6万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-14 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10676988
• 关键词: Acceleration; Address; Adverse effects; Affect; Analgesics; Animal Model; Area; Arthritis; Behavioral; Behavioral Assay; Bioinformatics; Chicago; Chronic; Clinical; Communication; Communities; Consultations; Disease; Education; Electrophysiology (science); Environment; Equipment; Fostering; Funding; Geography; Goals; Grant; Human; Infrastructure; Interdisciplinary Study; Investigation; Knowledge; Leadership; Musculoskeletal; Musculoskeletal Diseases; Musculoskeletal Pain; Musculoskeletal System; Neuroanatomy; Neurobiology; Neurosciences; Non-Steroidal Anti-Inflammatory Agents; Opioid; Pain; Pain Research; Patients; Pharmaceutical Preparations; Physiology; Population; Postdoctoral Fellow; Productivity; Protocols documentation; Research; Research Infrastructure; Research Personnel; Research Support; Resources; Rheumatism; Scientist; Services; Source; Techniques; Technology; Testing; Tissues; Training; Translational Research; Translations; behavior test; career; chronic musculoskeletal pain; chronic pain; collaborative environment; disability; drug action; in vivo calcium imaging; innovation; multidisciplinary; neuronal circuitry; new therapeutic target; novel; novel therapeutic intervention; novel therapeutics; opioid abuse; optogenetics; outreach; pain relief; prevent; programs; side effect; transcriptomics; web site

Project summary We seek to establish a new resource-based Center to foster and support research and training aimed at understanding the mechanisms underlying pain associated with musculoskeletal (MSK) and rheumatic diseases, with the ultimate goal of better managing and preventing it. One third of the world’s population is affected by chronic pain, and the MSK system is the most prevalent source of pain and disability. Currently available analgesic drugs act on a limited number of targets, and they do not provide sustained pain relief and their chronic use is associated with serious adverse effects. One of the major obstacles in identifying safe and efficacious drugs for producing pain relief is our general lack of understanding of the mechanisms underlying MSK pain, and how these mechanisms may overlap or differ between different types of rheumatic and MSK diseases. The Chicago Center on Musculoskeletal Pain (C-COMP) will address this need in a timely and unique manner, capitalizing on the world class expertise that is available to us in the areas of MSK research, pain and neurobiology to achieve the following broad long-term goals: (1) To integrate basic, translational and clinical expertise in a multidisciplinary Center which will provide the leadership and resources for promoting MSK pain research; (2) To enhance the research environment for the MSK research community by providing access to world-class expertise and state-of-the-art resources, technologies, and infrastructure for studying pain; (3) To promote interdisciplinary research between the MSK research field and the field of pain/neuroscience; (4) To expand the MSK pain research community by attracting early career as well as established researchers into this area of study. We envision three Cores operating in support of these overall goals. The Administrative Core A (PI: A.M. Malfait; co-director: J.J. Jacobs) will provide leadership, maintain effective communication, partner with related Centers to stimulate human translation of findings, and implement a dynamic enrichment program. The Behavioral Resource Core B (PI: R.E. Miller; co-director: D.R. Sumner) will provide a centralized resource to facilitate behavioral assays in a broad array of animal models of rheumatic and MSK diseases, including training for behavioral tests, access to customized protocols, equipment, and space to perform testing, a consultation service and a customized, full-service option for behavioral testing. The Neurobiology Core C (PI: RJ Miller; co- director: D.R. Sumner) will offer state-of-the-art techniques for assessment and manipulation of neuronal circuitry involved in pain physiology, such as in vivo calcium imaging, electrophysiology, chemo/optogenetics, transcriptomics/bioinformatics and neuroanatomical techniques. This will allow the Center’s research community to engage in cutting-edge investigations of the mechanisms of pain in animal models of MSK disease. In summary, C-COMP will provide (1) unique resources and infrastructure for supporting high-quality externally funded research and (2) pilot funding, education, and training in a multidisciplinary and collaborative fashion. This integrated approach is expected to accelerate research in pain associated with MSK and rheumatic disease.

项目概要 我们寻求建立一个新的以资源为基础的中心，以促进和支持旨在 了解与肌肉骨骼 (MSK) 和风湿性疾病相关的疼痛的机制， 最终目标是更好地管理和预防它。世界上三分之一的人口受到影响 慢性疼痛，而 MSK 系统是疼痛和残疾最普遍的来源。目前可用 镇痛药物作用于有限的目标，并且不能提供持续的疼痛缓解，并且其慢性疼痛 使用会带来严重的不良反应。识别安全有效的主要障碍之一 产生疼痛缓解药物的原因是我们普遍缺乏对 MSK 疼痛背后机制的了解，并且 这些机制在不同类型的风湿病和 MSK 疾病之间如何重叠或不同。这 芝加哥肌肉骨骼疼痛中心 (C-COMP) 将及时、独特地满足这一需求， 利用我们在 MSK 斯隆研究、疼痛和疾病领域的世界级专业知识 神经生物学以实现以下广泛的长期目标：（1）整合基础、转化和临床 多学科中心的专业知识将为促进 MSK 斯隆疼痛提供领导力和资源 研究; (2) 通过提供以下途径来改善 MSK 研究界的研究环境： 用于研究疼痛的世界一流的专业知识和最先进的资源、技术和基础设施； (3) 至 促进MSK研究领域与疼痛/神经科学领域之间的跨学科研究； (4) 至 通过吸引早期职业生涯以及成熟的研究人员加入该领域，扩大 MSK 斯隆疼痛研究社区 研究领域。我们设想三个核心的运作来支持这些总体目标。行政核心A （PI：A.M. Malfait；联合主任：J.J. Jacobs）将提供领导，保持有效沟通，与 相关中心刺激人类对研究结果的翻译，并实施动态丰富计划。这 行为资源核心 B（PI：R.E. Miller；联合主任：D.R. Sumner）将提供集中资源 促进多种风湿病和 MSK 疾病动物模型的行为测定，包括训练 对于行为测试，获得定制的协议、设备和空间来执行测试、咨询 服务以及行为测试的定制全方位服务选项。神经生物学核心 C（PI：RJ Miller；共同 导演：D.R. Sumner）将提供最先进的技术来评估和操纵神经元电路 涉及疼痛生理学，如体内钙成像、电生理学、化学/光遗传学、 转录组学/生物信息学和神经解剖学技术。这将使该中心的研究界 从事 MSK 疾病动物模型疼痛机制的前沿研究。在 总结一下，C-COMP将提供（1）独特的资源和基础设施来支持高质量的外部 以多学科和协作的方式资助研究和（2）试点资助、教育和培训。 这种综合方法预计将加速与 MSK 和风湿病相关的疼痛研究。