A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

一种了解功能性消化不良成人问题性回避/限制性饮食的生物行为方法

• 批准号: 10488265
• 负责人: Helen Burton Murray
• 金额: $ 19.95万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-13 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10488265
• 关键词: Address; Adult; Advisory Committees; Affect; Aftercare; Appetite Regulation; Applications Grants; Area; Behavior Therapy; Behavioral; Biological; Biological Markers; Biological Response Modifier Therapy; Body Image; Body Weight decreased; Burning Pain; Cholecystokinin; Chronic; Clinical; Clinical Investigator; Clinical Trials; Cognitive Therapy; Complement; Data; Development; Diet; Dyspepsia; Eating; Endocrine; Enrollment; Enteral Feeding; Epigastric; Evaluation; Exposure to; Food; Future; Gastroenterology; Gastroparesis; Goals; Health Care Costs; Hormones; Impairment; Individual; Intervention; K-Series Research Career Programs; Learning; Malnutrition; Medical; Mentors; Mentorship; Morbidity - disease rate; Motor; National Institute of Diabetes and Digestive and Kidney Diseases; Nausea; Nutritional status; Outcome; Patients; Peptide YY; Phase; Preparation; Protocols documentation; Psychologist; Psychology; Quality of life; Randomized; Randomized Controlled Trials; Research; Research Personnel; Research Priority; Role; Satiation; Scientist; Sensorimotor functions; Severities; Stomach; Symptoms; Testing; Training; United States National Institutes of Health; avoidant restrictive food intake disorder; base; behavioral clinical trial; behavioral study; biobehavior; biopsychosocial; career development; cohort; comparative efficacy; dietary approach; early satiety; experience; food avoidance; gastrointestinal; improved; improved outcome; innovation; interdisciplinary approach; meetings; motility disorder; multidisciplinary; patient oriented research; pilot test; programs; restrictive eating; satisfaction; skills; social; symptom management; translational scientist; treatment as usual; treatment research

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs and has limited treatment options. Detrimental eating- related medical consequences are frequent in FD, with a level of food avoidance/restriction meeting criteria for avoidant/restrictive food intake disorder (ARFID) in up to 40% of adults with FD. However, the biological mechanisms of problematic avoidant/restrictive eating in FD have been underexplored and could inform behavioral and biological intervention targets. This 5-year K23-Patient-Oriented Research Career Development award addresses this research gap by using an innovative, multi-disciplinary approach to examine: (1) differences in gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls; and (2) pilot feasibility, preliminary efficacy, and preliminary mechanisms of an exposure-based cognitive-behavioral treatment in patients with FD and ARFID. This project represents the first exploration of the mechanistic role of problematic avoidant/restrictive eating in FD and the potential benefit of an intervention that exposes patients with FD to increased food volume/variety. The training plan corresponding to this project will support Dr. Helen Burton Murray in becoming an independent clinical scientist with a program of research examining biopsychosocial target mechanisms of gastrointestinal functional/motility disorders to inform behavioral and biological treatment interventions. The study aims complement Dr. Burton Murray’s objectives for her advancement as an independent clinical and translational investigator, achieved through four training areas: gastric sensorimotor functions, endocrine regulation of appetite, behavioral clinical trials evaluation and treatment mechanisms, and career development. Training goals will be implemented under the guidance of Dr. Braden Kuo (primary mentor); Drs. Elizabeth A. Lawson and Jennifer J. Thomas (co- mentors); Drs. Brjánn Ljótsson and Brian Healy (consultants); and Drs. Lukas Van Oudenhove, Johnathan Williams, and Laurie Keefer (scientific advisory committee).

项目总结/摘要 功能性消化不良（FD）是一种慢性胃肠道功能/动力障碍， 成年人有显著的发病率和医疗费用，治疗选择有限。不良饮食- 相关的医学后果在FD中很常见，食物避免/限制水平符合以下标准： 避免/限制性食物摄入障碍（ARFID）在高达40%的FD成人。然而，生物 FD中有问题的回避/限制性饮食的机制尚未得到充分研究， 行为和生物干预目标。这5年K23-以患者为导向的研究职业发展 该奖项通过使用创新的多学科方法来研究这一研究差距：（1） 成人FD和ARFID、FD患者胃感觉运动功能和饱腹感激素的差异 无ARFID和健康对照;（2）试点可行性，初步疗效和初步机制 对FD和ARFID患者进行基于认知行为的治疗。该项目代表了 第一次探索有问题的回避/限制性饮食在FD中的机械作用， 使FD患者暴露于增加的食物量/种类的干预的益处。培训计划 该项目将支持Helen Burton Murray博士成为独立的临床科学家 通过一项研究计划，检查胃肠道功能/运动的生物心理社会目标机制 为行为和生物治疗干预提供信息。这项研究的目的是补充伯顿博士 Murray作为一名独立的临床和翻译研究者的目标已经实现。 通过四个方面的培训：胃感觉运动功能，食欲内分泌调节，行为临床 审判评价和治疗机制以及职业发展。培训目标将得到落实 Braden Kuo博士（主要导师）的指导下; Elizabeth A. Lawson和Jennifer J.托马斯（合作） 导师）; Brjánn Ljótsson和Brian Healy博士（顾问）; Lukas货车Oudenhove博士，Johnathan 威廉姆斯和劳里基弗（科学顾问委员会）。