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A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

一种了解功能性消化不良成人问题性回避/限制性饮食的生物行为方法

基本信息

批准号：
10696092
负责人：
Helen Burton Murray
金额：
$ 19.95万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-13 至 2026-09-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10696092
关键词：
Address Adult Advisory Committees Affect Aftercare Appetite Regulation Applications Grants Area Behavior Therapy Behavioral Biological Biological Markers Biological Response Modifier Therapy Body Image Body Weight decreased Cholecystokinin Chronic Clinical Clinical Investigator Clinical Trials Cognitive Therapy Complement Data Development Diet Dyspepsia Eating Eligibility Determination Endocrine Enrollment Enteral Feeding Epigastric Evaluation Exposure to Food Future Gastroenterology Gastroparesis Goals Health Care Costs Hormones Impairment Individual Intervention K-Series Research Career Programs Learning Malnutrition Medical Mentors Mentorship Morbidity - disease rate Motor National Institute of Diabetes and Digestive and Kidney Diseases Nausea Nutritional status Outcome Pain Patients Peptide YY Phase Preparation Protocols documentation Psychologist Psychology Quality of life Randomized Randomized, Controlled Trials Research Research Personnel Research Priority Role Satiation Scientist Sensorimotor functions Severities Stomach Symptoms Testing Training United States National Institutes of Health avoidant restrictive food intake disorder behavioral clinical trial behavioral study biobehavior biopsychosocial career development cohort dietary approach early satiety experience food avoidance gastrointestinal improved improved outcome innovation interdisciplinary approach meetings motility disorder multidisciplinary patient oriented research pilot test programs restrictive eating satisfaction skills social symptom management translational scientist treatment as usual treatment research

项目摘要

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs and has limited treatment options. Detrimental eating- related medical consequences are frequent in FD, with a level of food avoidance/restriction meeting criteria for avoidant/restrictive food intake disorder (ARFID) in up to 40% of adults with FD. However, the biological mechanisms of problematic avoidant/restrictive eating in FD have been underexplored and could inform behavioral and biological intervention targets. This 5-year K23-Patient-Oriented Research Career Development award addresses this research gap by using an innovative, multi-disciplinary approach to examine: (1) differences in gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls; and (2) pilot feasibility, preliminary efficacy, and preliminary mechanisms of an exposure-based cognitive-behavioral treatment in patients with FD and ARFID. This project represents the first exploration of the mechanistic role of problematic avoidant/restrictive eating in FD and the potential benefit of an intervention that exposes patients with FD to increased food volume/variety. The training plan corresponding to this project will support Dr. Helen Burton Murray in becoming an independent clinical scientist with a program of research examining biopsychosocial target mechanisms of gastrointestinal functional/motility disorders to inform behavioral and biological treatment interventions. The study aims complement Dr. Burton Murray’s objectives for her advancement as an independent clinical and translational investigator, achieved through four training areas: gastric sensorimotor functions, endocrine regulation of appetite, behavioral clinical trials evaluation and treatment mechanisms, and career development. Training goals will be implemented under the guidance of Dr. Braden Kuo (primary mentor); Drs. Elizabeth A. Lawson and Jennifer J. Thomas (co- mentors); Drs. Brjánn Ljótsson and Brian Healy (consultants); and Drs. Lukas Van Oudenhove, Johnathan Williams, and Laurie Keefer (scientific advisory committee).

项目总结/文摘