A Biobehavioral Approach to Understand Problematic Avoidant/Restrictive Eating in Adults with Functional Dyspepsia

一种了解功能性消化不良成人问题性回避/限制性饮食的生物行为方法

• 批准号: 10841228
• 负责人: Helen Burton Murray
• 金额: $ 7.56万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-13 至 2026-09-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10841228
• 关键词: Address; Administrative Supplement; Adult; Advisory Committees; Affect; Aftercare; Appetite Regulation; Area; Award; Behavior Therapy; Behavioral; Biological; Biological Markers; Biological Response Modifier Therapy; Body Image; Body Weight decreased; Cholecystokinin; Chronic; Clinical; Clinical Investigator; Clinical Trials; Cognitive Therapy; Complement; Data; Data Collection; Development; Diet; Dyspepsia; Eating; Eligibility Determination; Endocrine; Enrollment; Enteral Feeding; Epigastric; Essential worker; Evaluation; Exposure to; Food; Future; Gastroparesis; Goals; Health Care Costs; Hormones; Impairment; Individual; Intervention; Investigation; K-Series Research Career Programs; Learning; Malnutrition; Medical; Mentors; Mentorship; Morbidity - disease rate; Motor; Nausea; Nutritional status; Outcome; Pain; Parents; Patients; Peptide YY; Phase; Protocols documentation; Psychologist; Quality of life; Randomized; Randomized, Controlled Trials; Research; Role; Satiation; Scientist; Sensorimotor functions; Severities; Stomach; Symptoms; Training; avoidant restrictive food intake disorder; behavioral clinical trial; biobehavior; biopsychosocial; career development; cohort; dietary approach; early satiety; experience; feasibility testing; food avoidance; gastrointestinal; improved; improved outcome; innovation; interdisciplinary approach; meetings; motility disorder; patient oriented research; pilot test; preservation; programs; restrictive eating; satisfaction; skills; social; success; symptom management; timeline; translational scientist; treatment as usual; treatment research

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs and has limited treatment options. Detrimental eating- related medical consequences are frequent in FD, with a level of food avoidance/restriction meeting criteria for avoidant/restrictive food intake disorder (ARFID) in up to 40% of adults with FD. However, the biological mechanisms of problematic avoidant/restrictive eating in FD have been underexplored and could inform behavioral and biological intervention targets. This 5-year K23-Patient-Oriented Research Career Development award addresses this research gap by using an innovative, multi-disciplinary approach to examine: (1) differences in gastric sensorimotor functions and satiety hormones among adults with FD and ARFID, FD without ARFID, and healthy controls; and (2) pilot feasibility, preliminary clinical outcomes, and preliminary mechanisms of an exposure-based cognitive-behavioral treatment in patients with FD and ARFID. This project represents the first exploration of the mechanistic role of problematic avoidant/restrictive eating in FD and the potential benefit of an intervention that exposes patients with FD to increased food volume/variety. The training plan corresponding to this project will support Dr. Helen Burton Murray in becoming an independent clinical scientist with a program of research examining biopsychosocial target mechanisms of gastrointestinal functional/motility disorders to inform behavioral and biological treatment interventions. The study aims complement Dr. Burton Murray’s objectives for her advancement as an independent clinical and translational investigator, achieved through four training areas: gastric sensorimotor functions, endocrine regulation of appetite, behavioral clinical trials evaluation and treatment mechanisms, and career development. Training goals will be implemented under the guidance of Dr. Braden Kuo (primary mentor); Drs. Elizabeth A. Lawson and Jennifer J. Thomas (co-mentors); Drs. Brjánn Ljótsson and Brian Healy (consultants); and Drs. Lukas Van Oudenhove, Johnathan Williams, and Laurie Keefer (scientific advisory committee). The purpose of this proposed supplement award is to provide Dr. Burton Murray with essential staff support during the most active data collection year planned. Supplement support will preserve the success of Dr. Burton Murray in achieving the above aims and facilitate her successful K-to-R transition.

项目概要/摘要 功能性消化不良 (FD) 是一种慢性胃肠道功能/运动障碍，影响高达 12% 的美国人 发病率高、医疗费用高且治疗选择有限的成年人。饮食有害—— 相关的医疗后果在 FD 中很常见，避免/限制食物的程度符合以下标准： 高达 40% 的 FD 成人患有回避/限制性食物摄入障碍 (ARFID)。然而，生物 FD 中存在问题的回避/限制性饮食的机制尚未得到充分探索，可以为 FD 患者提供指导 行为和生物干预目标。这个为期 5 年的 K23 以患者为导向的研究职业发展 该奖项通过使用创新的多学科方法来研究以下方面，从而弥补了这一研究空白：(1) FD 和 ARFID、FD 成人胃感觉运动功能和饱腹感激素的差异 没有ARFID，以及健康的控制； (2) 试点可行性、初步临床结果和初步结果 FD 和 ARFID 患者基于暴露的认知行为治疗机制。这个项目 代表了对有问题的回避/限制性饮食在 FD 和 让 FD 患者增加食物量/种类的干预措施的潜在益处。培训内容 与该项目相对应的计划将支持 Helen Burton Murray 博士成为一名独立的临床医生 科学家，其研究计划检查胃肠道的生物心理社会目标机制 功能/运动障碍为行为和生物治疗干预提供信息。研究目的 补充 Burton Murray 博士作为独立临床和转化医师的发展目标 研究者，通过四个训练领域实现：胃感觉运动功能、内分泌调节 食欲、行为临床试验评估和治疗机制以及职业发展。训练 目标将在Braden Kuo博士（主要导师）的指导下实施；博士。伊丽莎白·劳森 和 Jennifer J. Thomas（共同导师）；博士。 Brjánn Ljótsson 和 Brian Healy（顾问）；和博士。卢卡斯·范 Oudenhove、Johnathan Williams 和 Laurie Keefer（科学顾问委员会）。这样做的目的 拟议的补充奖励旨在为 Burton Murray 博士在治疗期间提供必要的工作人员支持 计划最活跃的数据收集年。补充支持将保持伯顿博士的成功 Murray 实现了上述目标，并促进了她成功从 K 到 R 的过渡。

项目成果

Validation of the youth-nine item avoidant/restrictive food intake disorder screen.

青少年九项回避/限制性食物摄入障碍筛查的验证。

• DOI: 10.1002/erv.3017
• 发表时间: 2024
• 期刊: European eating disorders review : the journal of the Eating Disorders Association
• 作者: BillmanMiller,MarleyG;Zickgraf,HanaF;Murray,HelenBurton;Essayli,JamalH;Lane-Loney,SusanE
• 通讯作者: Lane-Loney,SusanE

Psychological Considerations in the Dietary Management of Patients With DGBI.

• DOI: 10.14309/ajg.0000000000001766
• 发表时间: 2022-06-01
• 期刊: The American journal of gastroenterology

Does Gluten Avoidance in Patients with Celiac Disease Increase the Risk of Developing Eating Disorders?

乳糜泻患者避免麸质是否会增加饮食失调的风险？

• DOI: 10.1007/s10620-023-07915-3
• 发表时间: 2023
• 期刊: Digestive diseases and sciences
• 影响因子: 3.1
• 作者: Abber,SophieR;BurtonMurray,Helen
• 通讯作者: BurtonMurray,Helen

Analysis of Age, Race, Ethnicity, and Sex of Participants in Clinical Trials Focused on Disorders of Gut-Brain Interaction.

• DOI: 10.1053/j.gastro.2022.05.049
• 发表时间: 2022-09
• 期刊: Gastroenterology
• 影响因子: 29.4

Assessing the presence and motivations of orthorexia nervosa among athletes and adults with eating disorders: a cross-sectional study.

• DOI: 10.1007/s40519-023-01631-7
• 发表时间: 2023-12-09
• 期刊: EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
• 影响因子: 2.9
• 作者: Foyster, Mandy;Sultan, Nessmah;Tonkovic, Matilda;Govus, Andrew;Burton-Murray, Helen;Tuck, Caroline J.;Biesiekierski, Jessica R.
• 通讯作者: Biesiekierski, Jessica R.