Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase Study

项目摘要 这是华盛顿大学申请继续作为第二阶段的临床研究中心， 下尿路功能障碍症状研究网络（LURN）LURN的目标 研究目的：（1）增加对下尿路症状（LUTS）表型的了解， 患者亚型背后的潜在机制和（2）制定一个全面的，有效的， 用于定义治疗效果的响应性测量工具。在成功完成最初的5年供资周期后， 团结会准备在所获得的知识的基础上采取以下步骤，具体目标如下： 目的1：完善和扩展临床相关的聚类模型，包括更广泛的患者队列 的症状严重程度和更广泛的生理措施，并随访三年。 目的2：通过测量下丘脑的功能成分，更深入地对LUTS女性进行表型分析 泌尿道（膀胱和尿道的肌肉，以及传入和传出神经） 尿急不伴尿失禁、尿急伴尿失禁和正常对照。 目的3：鉴定男性和女性特定亚组血浆中所含蛋白质的特征 与LUTS 目标4：为患有LUTS的男性和女性验证一个全面的结果工具。 目的5：评估男性和女性膀胱过度活动综合征（OAB）患者的中枢敏感性， 比较它们的临床表型、聚类成员和血清蛋白特征。

PROJECT ABSTRACT This is an application from the Washington University to continue to be a clinical site for the second phase of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The objectives of the LURN Study are to: (1) increase the understanding of lower urinary tract symptoms (LUTS) phenotypes and underlying mechanisms behind the patient subtypes and (2) develop a comprehensive, validated, and responsive measurement tools for defining treatment efficacy. After a successful initial 5-year funding cycle, LURN is prepared to build on the knowledge gained and take the next steps with the following Specific Aims: Aim 1: To refine and expand a clinically-relevant cluster model with a cohort of patients including wider range of symptom severity and a wider range of physiologic measures and followed for three years. Aim 2: To more deeply phenotype women with LUTS by measuring the functional components of the lower urinary tract (muscles of the bladder and urethra, and afferent and efferent nerves) in those with urinary urgency without incontinence, urinary urgency with incontinence, and normal controls. Aim 3: To identify a signature of proteins contained within plasma of specific subgroups of men and women with LUTS. Aim 4: To validate a comprehensive outcome tool for men and women with LUTS. Aim 5: To assess central sensitization in male and female patients with overactive bladder syndrome (OAB), compare their clinical phenotypes, cluster memberships, and serum protein signatures.