Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) Second Phase Study

项目摘要 这是来自华盛顿大学的申请，继续作为第二阶段的临床地点 下尿路功能障碍症状研究网络(Lurn)。Lurn的目标 研究的目的是：(1)增加对下尿路症状(LUTS)表型和 患者亚型背后的潜在机制以及(2)制定全面、有效和 用于确定治疗效果的响应性测量工具。在最初成功的5年筹资周期之后， Lurn准备在已获得的知识的基础上采取下一步行动，具体目标如下： 目标1：完善和扩展与临床相关的集群模型，包括更广泛的患者队列 症状严重程度和更广泛的生理措施，并随访三年。 目的2：通过测量LUTS患者下半身的功能成分，深入了解LUTS患者的表型 尿毒症患者的尿路(膀胱肌和尿道肌，以及传入和传出神经) 无尿失禁的尿急，有尿失禁的尿急，以及正常对照。 目的3：确定男性和女性特定亚群血浆中所含蛋白质的特征 和LUTS一起。 目的4：验证一种适用于LUTS患者的综合结果工具。 目的5：评估男性和女性膀胱过度活动症(OAB)患者的中枢敏感化。 比较他们的临床表型、簇成员和血清蛋白特征。

PROJECT ABSTRACT This is an application from the Washington University to continue to be a clinical site for the second phase of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). The objectives of the LURN Study are to: (1) increase the understanding of lower urinary tract symptoms (LUTS) phenotypes and underlying mechanisms behind the patient subtypes and (2) develop a comprehensive, validated, and responsive measurement tools for defining treatment efficacy. After a successful initial 5-year funding cycle, LURN is prepared to build on the knowledge gained and take the next steps with the following Specific Aims: Aim 1: To refine and expand a clinically-relevant cluster model with a cohort of patients including wider range of symptom severity and a wider range of physiologic measures and followed for three years. Aim 2: To more deeply phenotype women with LUTS by measuring the functional components of the lower urinary tract (muscles of the bladder and urethra, and afferent and efferent nerves) in those with urinary urgency without incontinence, urinary urgency with incontinence, and normal controls. Aim 3: To identify a signature of proteins contained within plasma of specific subgroups of men and women with LUTS. Aim 4: To validate a comprehensive outcome tool for men and women with LUTS. Aim 5: To assess central sensitization in male and female patients with overactive bladder syndrome (OAB), compare their clinical phenotypes, cluster memberships, and serum protein signatures.