Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network Extension Study

项目摘要 这是华盛顿大学探索网站继续参与MAPP的申请 中国互联网.多学科方法研究慢性盆腔疼痛（MAPP）的研究 NIDDK建立了一个网络来研究泌尿系慢性疾病的病因和治疗的自然史， 骨盆疼痛综合征（UCPPS），通过改善症状的治疗和管理 临床试验的设计，并确定临床因素和研究测量，以确定临床相关 这些患者的亚组（“表型”）。MAPP网络的第二个项目期（2014-2019年） 一项名为Trans-MAPP症状模式研究（SPS）的方案涉及UCPPS的综合表型分析 基线时和36个月纵向观察期内的参与者，使用扩展测量， 进一步细化UCPPS亚组，确定症状趋势，并发现相关的风险因素和生物学 与进展情况相关。截至2018年10月，570名患有UCPPS的男性和女性参加了 MAPP II研究，我们预计到2018年12月底达到600人的招募目标。当前 资助期将于2019年7月结束。我们提议将资助期限延长三年，至2022年7月。期间 延长三年的目标是： 目标1：在MAPP-II SPS中获得额外的12个月随访。 目标2：观察MAPP-II SPS中的其他ATLAS事件。 目标3：对MAPP II数据进行分析。

PROJECT SUMMARY This is an application from the Washington University Discovery Site to continue participation in the the MAPP Research Network. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network was established by the NIDDK to study the etiology and treated natural history of urologic chronic pelvic pain syndrome (UCPPS), to inform better treatments and management of symptoms through improved designs of clinical trials, and to identify clinical factors and research measurements to define clinically relevant sub-groups (“phenotypes”) of these patients. The MAPP Network’s second Project Period (2014-2019) central protocol, the Trans-MAPP Symptom Patterns Study (SPS), involves integrated phenotyping of UCPPS participants at baseline and during a 36-month longitudinal, observational period using expanded measures to further refine UCPPS subgrouping, identify symptom trends, and discover associated risk factors and biological correlates to progression profiles. As of October 2018, 570 men and women with UCPPS are enrolled in the MAPP II study, and we expect to meet the recruitment goal of 600 by the end of December 2018. The current funding period ends in July 2019. We propose a three-year funding extension, through July 2022. During the three-year extension we aim to accomplish the following: Aim 1: To Obtain an Additional 12 Months of Follow-up in the MAPP-II SPS. Aim 2: To Observe Additional ATLAS Events in the MAPP-II SPS. Aim 3: To Conduct Analyses of MAPP II Data.