AD/ADRD Pilot Core

AD/ADRD 试点核心

• 批准号: 10491793
• 负责人: GRACIELA GONZALEZ HERNANDEZ
• 金额: $ 190.97万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10491793
• 关键词: Acute; Address; Adoption; Adult; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Arizona; Artificial Intelligence; Back; Biostatistics Core; Caregivers; Caring; Clinic; Clinical; Clinical Data; Collaborations; Communities; Computer software; Data; Database Management Systems; Development; Diagnosis; Educational workshop; Engineering; Ensure; Ethics; Experimental Designs; Feedback; Fostering; Funding; Goals; Health; Health Services Accessibility; Health system; Home; Industry; Informatics; Institutes; Institution; Journals; Link; Machine Learning; Mentors; Methodology; Methods; Mission; Modeling; Monitor; Names; Patients; Pennsylvania; Pilot Projects; Policies; Predictive Analytics; Preparation; Process; Production; Publications; Request for Proposals; Research; Research Activity; Research Personnel; Science; Series; Site; Students; Study Section; Supervision; Technology; Testing; Training; Training and Education; United States National Institutes of Health; United States National Library of Medicine; Universities; Validation; aging in place; biomedical informatics; career; clinical care; clinical decision support; clinical research site; clinical translation; collaboratory; community organizations; cooperative study; data integration; design; healthy aging; human capital; innovation; innovative technologies; language processing; member; mid-career faculty; neuroimaging; new technology; novel; peer networks; point of care; programs; provider networks; senior faculty; software systems; success; symposium

AD/ADRD Focus Pilot Core (Core F) Project Summary The overarching goal of the Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) Focus Pilot Core (Core F) is to promote the advancement of science and engineering for predictive analytics, for clinical decision support, or for the care of adults with AD/ADRD. To advance this mission, we will solicit, fund, and support pilot projects focused on innovative technologies and AI approaches for several important aspects of aging in place, and, more specifically, projects that respond to the specific challenges of those with an AD/ADRD diagnosis. To name a few, we will fund pilots focused on developing AI methods and software for the processing and integration of data from home monitoring technology with clinical data from EHRs, on analysis of integrated data using automated machine learning, or on incorporating validated AI models into clinical workflows for decision support within a health system, in the home, or any other point of care. The core will be led by Dr. Graciela Gonzalez-Hernandez, Associate Professor of Informatics and Senior Faculty of the Institute of Biomedical Informatics (IBI) at the University of Pennsylvania, and Director of the Health Language Processing (HLP) Center within the institute. With over 100 publications in prestigious journals and conferences, Dr Gonzalez-Hernandez’s 19 years of academic career plus 5 more in industry bring a unique perspective with respect to the integration of research and applicable software systems, and their adequate construction and distribution. She was Director of the Database Management and Biostatistics Core for the NIH-funded Arizona Alzheimer’s Disease Center for 8 years (2008 to 2016), where she helped organize the annual selection of Pilot Projects. She is a member of the NLM Board of Scientific Advisors (effective as of the Spring of 2021) and of the NIH Biodata Management and Analysis (BDMA) study section since 2019. She was previously a member of the NIH/NLM BLIRC study section (2009-2013). Overall, in line with the overarching theme of the PennAITech Collaborative, Core F seeks to provide comprehensive, integrated, and continuous support and promotion of Pilot projects that connect novel technologies for monitoring aging adults in the home with research activities and clinical care, specifically aimed at addressing the acute needs of the AD/ADRD patients and their caregivers and the specific nuances and progression of AD/ADRD. To our knowledge, a comprehensive pipeline from home to clinic and back that addresses the many challenges of AD/ADRD does not yet exist. Building and extending this pipeline will be central to our pilot funding program. The AD/ADRD Pilot Core has the following Specific Aims: (1) to solicit, review, and support pilot studies that develop or advance the use of AI and technology for AD/ADRD predictive analytics, clinical decision support, or the care of adults with AD/ADRD, (2) to foster collaborations among affiliated Penn investigators, our network of peer institutions and research centers, and pilot program researchers, and (3) to provide high quality informatics, computational, and product design and development support, education, and training for researchers, pilot project applicants, and collaborators.

AD/ADRD焦点试点核心（核心F）项目摘要 阿尔茨海默病和阿尔茨海默病相关痴呆（AD/ADRD）焦点的总体目标 试点核心（核心F）是促进科学和工程的进步，用于预测分析，临床 决策支持，或用于AD/ADRD成人的护理。为了推进这一使命，我们将征集、资助和 支持试点项目，重点关注创新技术和人工智能方法的几个重要方面， 就地老龄化，更具体地说，是应对AD/ADRD患者具体挑战的项目 诊断.仅举几例，我们将资助专注于开发人工智能方法和处理软件的试点项目。 家庭监测技术的数据与电子健康记录的临床数据的整合， 使用自动化机器学习数据，或将经验证的AI模型纳入临床工作流程， 在卫生系统、家庭或任何其他护理点内提供决策支持。核心将由博士领导。 Graciela Gonzalez-Hernandez，信息学副教授和研究所高级教师 宾夕法尼亚大学生物医学信息学（IBI）和健康语言处理主任 (HLP)研究所内的中心。博士在著名期刊和会议上发表了100多篇论文， 冈萨雷斯-埃尔南德斯19年的学术生涯加上5年以上的工业带来了独特的视角， 尊重研究和应用软件系统的整合，以及它们的适当建设， 分布她是NIH资助的亚利桑那州数据库管理和生物统计核心主任 阿尔茨海默病中心8年（2008年至2016年），在那里她帮助组织了飞行员的年度评选 项目她是NLM科学顾问委员会的成员（自2021年春季起生效）， NIH生物数据管理和分析（BDMA）研究部分自2019年以来。她以前是 NIH/NLM BLIRC研究部分（2009-2013）。总的来说，与PennAITech的总体主题一致， 合作，核心F寻求提供全面，综合和持续的支持和促进 将监测家中老年人的新技术与研究活动相结合的试点项目 和临床护理，专门针对AD/ADRD患者及其护理人员的急性需求 以及AD/ADRD的具体细微差别和进展。据我们所知，一个全面的管道从家里 目前还不存在解决AD/ADRD的许多挑战的临床和背部。建造和扩建 这条管道将是我们试点资金计划的核心。AD/ADRD试点核心具有以下特定 目的：（1）征求，审查和支持试点研究，开发或推进人工智能和技术的使用， AD/ADRD预测分析、临床决策支持或AD/ADRD成人护理，（2）促进 宾夕法尼亚大学附属研究人员之间的合作，我们的同行机构和研究中心网络，以及 试点项目研究人员，（3）提供高质量的信息学，计算和产品设计， 为研究人员、试点项目申请人和合作者提供发展支持、教育和培训。