NYU Cancer Health Disparity (CHD) SPORE

纽约大学癌症健康差异 (CHD) SPORE

• 批准号: 10265452
• 负责人: Jiyoung Ahn
• 金额: $ 112.55万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-17 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10265452
• 关键词: Achievement; Address; Adjuvant Chemotherapy; Area; Asians; Bioinformatics; Biological; Biological Factors; Biometry; Cancer Center; Cancer Control; Cancer Patient; Case-Control Studies; Cessation of life; Clinic; Clinical; Colon Carcinoma; Colonic Neoplasms; Communities; Complex; Comprehensive Cancer Center; Coupling; Data; Development; Ethnic Origin; Exhibits; Fostering; Goals; Head Cancer; Head and Neck Cancer; Health; Helicobacter pylori; Human; Human Microbiome; Human Papillomavirus; Immune; Incidence; Individual; Intervention; Knowledge; Lead; Malignant Neoplasms; Malignant neoplasm of liver; Metagenomics; Microbe; Minority; Minority Groups; Neck Cancer; Nested Case-Control Study; New York City; Participant; Patients; Phenotype; Population Heterogeneity; Prevention trial; Process; Prospective cohort; Race; Recurrence; Regulation; Research; Research Personnel; Resources; Role; Sampling; Shapes; Socioeconomic Factors; Solid; Therapeutic Clinical Trial; Translating; Treatment outcome; Work; base; burden of illness; cancer health disparity; cancer prevention; cancer recurrence; cancer therapy; clinical practice; cohort; colon cancer patients; commensal microbes; evidence base; genome-wide; gut microbiome; high risk; high risk population; human microbiota; immune function; improved; individualized prevention; malignant stomach neoplasm; microbial; microbiome; microbiota; mortality; multi-ethnic; novel; oral microbiome; pathogen; personalized intervention; population based; programs; prophylactic; prospective; racial disparity; racial diversity; racial minority; socioeconomic disparity; tool; translational research program; tumor; tumor-immune system interactions; tumorigenesis

PROJECT SUMMARY Orodigestive tract (ODT) cancers, which account for 32% of cancer deaths in the US, exhibit striking racial disparities in incidence and mortality burdens. Our central hypothesis is that the human microbiome contributes to ODT cancer disparities through biologic interaction of the microbiome with the host in ODT oncogenesis. The overall objective of the NYU Cancer Health Disparity (CHD) SPORE is to develop a comprehensive translational research program to identify, understand and control the microbiota that account for orodigestive track (ODT) cancer disparities. Project 1 will focus on the relationship of the oral microbiome to racial and socioeconomic disparities in the incidence of head and neck cancer, by means of a prospective case-control study nested within 3 large highly diverse US cohorts. Project 2 will focus on the gut microbiome and Black and White racial disparities in tumor recurrence in colon cancer patients who received adjuvant chemotherapy. Our research will be strongly supported through shared Cores: (A) Administrative, (B) Biospecimen Procurement & Utilization, and (C) Biostatistics and Bioinformatics. The proposal brings together a highly transdisciplinary team of investigators that work collaboratively through every stage of the proposed research to accomplish the translational goal of this P20 application. The NYU CHD SPORE will provide new knowledge on specific human microbiota that contribute to ODT cancer disparities and will advance our understanding of the functional consequences of these microbiota in ODT oncogenesis. The knowledge gained from the proposed research in the P20 SPORE will transform current clinical practice by identifying high risk groups for ODT cancer in minority populations, that will provide the scientific basis for developing microbially-based personalized prevention, clinical decision tools, and prophylactic interventions to address ODT cancer disparities. Achievement of the P20 SPORE will lay a solid groundwork for a P50 SPORE to translate these evidence-based findings of microbial factors contributing to ODT cancer disparity into actionable practice-based interventions at the clinic and community level.

项目概要 口腔消化道 (ODT) 癌症占美国癌症死亡人数的 32%，具有显着的种族差异 发病率和死亡率负担的差异。我们的中心假设是人类微生物组有助于 通过 ODT 肿瘤发生过程中微生物组与宿主的生物相互作用来了解 ODT 癌症差异。这 纽约大学癌症健康差异 (CHD) SPORE 的总体目标是开发一个全面的转化 识别、理解和控制口腔消化道 (ODT) 微生物群的研究计划 癌症差异。项目 1 将重点关注口腔微生物组与种族和社会经济的关系 通过一项前瞻性病例对照研究，了解头颈癌发病率的差异 3 个高度多样化的美国群体。项目 2 将重点关注肠道微生物组和黑人和白人种族 接受辅助化疗的结肠癌患者肿瘤复发的差异。我们的研究将 通过共享核心得到大力支持：(A) 行政，(B) 生物样本采购和利用，以及 (C) 生物统计学和生物信息学。该提案汇集了高度跨学科的研究团队 在拟议研究的每个阶段进行协作，以实现以下目标： 这个P20应用程序。纽约大学 CHD SPORE 将提供有关特定人类微生物群的新知识 有助于 ODT 癌症差异，并将增进我们对这些功能后果的理解 ODT 肿瘤发生中的微生物群。从 P20 SPORE 中拟议的研究中获得的知识将 通过识别少数群体中 ODT 癌症的高危人群来改变当前的临床实践，这将 为开发基于微生物的个性化预防、临床决策工具和 解决 ODT 癌症差异的预防性干预措施。 P20 SPORE的成功将为 为 P50 SPORE 转化这些基于证据的微生物因素发现奠定了基础 ODT 癌症差异成为临床和社区层面可行的基于实践的干预措施。