PHASE I SBIR CONTRACT - TOPIC 415 - A Compact and Retrofittable Electronic Brachytherapy Source for Cancer Radiotherapy

第一期 SBIR 合同 - 主题 415 - 用于癌症放射治疗的紧凑型可改装电子近距离放射治疗源

• 批准号: 10496695
• 负责人: CHUNGUANG JING
• 金额: $ 39.99万
• 依托单位: EUCLID BEAMLABS, LLC
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-16 至 2022-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10496695
• 关键词: Brachytherapy; Caliber; Characteristics; Clinical; Communities; Contracts; Development; Devices; Dimensions; Dose; Dose-Rate; Electron Beam; Electrons; Elements; Future; Goals; High-Dose Rate Brachytherapy; Hospitals; In Vitro; Laboratories; Measurement; Measures; Medical; Patients; Penetration; Phase; Photons; Radiation; Radioisotopes; Readiness; Robotics; Roentgen Rays; Small Business Innovation Research Grant; Source; Structure; System; Technology; Testing; Thick; Tissues; Weight; arm; attenuation; base; cancer radiation therapy; clinically relevant; conditioning; design; efficacy study; improved; in silico; interest; light weight; novel; prototype; user-friendly

The use of electronic brachytherapy (EB) has grown rapidly over the past decade, and is gaining significant interest from the global medical community as an improved user-friendly technology. However, the present EB machines all use electron beams at energies of 100 kV or less to generate the X-ray photons, which limits their use to low dose-rate brachytherapy. In this proposal, Euclid Beamlabs focuses on the development of an ultra-compact and light weight 1- MeV electron source to generate and deliver >250 kV X-ray photons to the patient. The device is intended to retrofit to existing brachytherapy applicators. Our proposed accelerating structure is a dielectric-based accelerator. Because of the use of high permittivity dielectrics, the transverse size of the cavity is significantly reduced, becoming comparable to the thickness of a pencil. With the help of optimized focusing elements, the beam will be transported through a 1~2-mm diameter pipe to the Bremsstrahlung radiation target, thus delivering the dose in a highly localized regime. The dimension of the pipe will be chosen for compatibility with existing brachytherapy applicators. In Phase I, we will develop a fully functioning prototype and measure its critical parameters, including the delivered electron and photon energies, the dose rate, etc. The Technical Readiness Level (TRL) of the developed technology will reach TRL4 (feasibility proved) upon the completion of Phase I.

在过去的十年中，电子近距离放射治疗（EB）的使用迅速增长，并且正在获得显着 全球医学界的兴趣是一种改进的用户友好技术。但是，当前的EB机器 所有人都以100 kV或更少的能量使用电子束来产生X射线光子，这将其用于低剂量率 近距离放射治疗。在此提案中，欧几里德梁标记着重于超压缩和轻巧1-的发展 MEV电子源可生成并向患者传递> 250 kV X射线光子。该设备旨在改造为 现有的近距离放射治疗剂。我们提出的加速结构是基于介电的加速器。因为 使用高介电常数的介电特性，腔的横向大小显着降低，与 铅笔的厚度。借助优化的聚焦元素，将通过1〜2毫米运输光束 直径的管道到BREMSSTRAHLUNG辐射靶标，从而在高度局部的方向上递送剂量。这 将选择管道的尺寸与现有的近距离放射治疗剂的兼容性。在第一阶段，我们将发展 一个功能齐全的原型，并测量其临界参数，包括传递的电子和光子能量， 剂量率等。发达技术的技术准备水平（TRL）将达到TRL4（证明可行性） 第1阶段完成后