BERTI; Biomedical implant with Exceptional Resistance to Tribo-bio-corrosion and with Inherent antimicrobial properties

贝尔蒂；

• 批准号: 101005
• 金额: $ 74.29万
• 依托单位: CORIN LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2011
• 资助国家: 英国
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=101005
• 关键词: BERTI; Biomedical; implant; Exceptional; Resistance

The objective of project BERTI (Biomedical implant with Exceptional Resistance to Tribo-bio-corrosion and with Inherent antimicrobial properties) is to develop an innovative joint replacement with a coating that minimises polyethylene and metal wear debris, prevents metal ion release and promotes the release of antimicrobial agents. The project will determine a method that establishes drivers for the detrimental responses to wear debris observed in patients. This information will be used to optimise a recently develop physical-vapour deposition coating that minimises wear and tribo-bio-corrosion while delivering an antimicrobial agent. In addition, the project will establish a test for patient susceptibility to ions release from implants. This will help identify patient cohorts who would benefit most from the novel coated implants, and will deliver to them, and to the wider population, a world-leading joint replacement with exceptional biocompatibility, longevity and antimicrobial properties. Project BERTI will ultimately increase the longevity of orthopaedic implants, reducing the number of revision surgeries, benefiting the UK and wider economy, and the patient.

BERTI项目（具有优异的抗摩擦生物腐蚀和固有抗菌性能的生物医学植入物）的目标是开发一种具有涂层的创新关节替代物，该涂层可以最大限度地减少聚乙烯和金属磨损碎片，防止金属离子释放并促进抗菌剂的释放。该项目将确定一种方法，确定患者观察到的磨损碎片有害反应的驱动因素。这些信息将用于优化最近开发的物理气相沉积涂层，该涂层在提供抗菌剂的同时最大限度地减少磨损和摩擦-生物腐蚀。此外，该项目还将建立一项测试，以检测患者对植入物释放的离子的敏感性。这将有助于确定从新型涂层植入物中获益最多的患者群体，并将向他们和更广泛的人群提供具有卓越生物相容性，寿命和抗菌性能的世界领先的关节置换术。BERTI项目最终将增加骨科植入物的使用寿命，减少整形手术的数量，使英国和更广泛的经济以及患者受益。