17/24 Healthy Brain and Child Development National Consortium

17/24 健康大脑和儿童发展国家联盟

• 批准号: 10494131
• 负责人: Michael K. Georgieff
• 金额: $ 135.94万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-30 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10494131
• 关键词: 10 year old; Address; Adverse event; Affect; Alcohols; Behavioral; Biological; Birth; Brain; COVID-19; Caregivers; Child; Child Development; Communities; Complement; Conceptions; DNA; Data; Data Collection; Data Coordinating Center; Data Set; Development; Enrollment; Environment; Environmental Exposure; Environmental Hazards; Epigenetic Process; Ethics; Event; Exposure to; Feedback; General Population; Genes; Goals; Health; Helping to End Addiction Long-term; Human; Infant; Infection; Life; Link; Location; Malnutrition; Marijuana; Maternal Health; Measures; Methods; Modality; Monitor; Mothers; Newborn Infant; Opiate Addiction; Opioid; Outcome; Participant; Persons; Physiological; Population; Pregnancy; Pregnant Women; Process; Protocols documentation; Psychopathology; Public Health; Public Policy; Research; Research Design; Research Personnel; Sampling; Second Pregnancy Trimester; Severities; Shapes; Site; Speed; Stress; Structural Racism; Time; Time Study; Tobacco; Toxicant exposure; Training; United States; United States National Institutes of Health; Woman; Work; base; caregiving; child bearing; cohort; critical period; data harmonization; data integrity; data standards; design; early experience; early life exposure; experience; hazard; high dimensionality; improved; innovation; insight; magnetic resonance imaging/electroencephalography; maltreatment; maternal stress; multimodality; neurodevelopment; neuroimaging; novel; opioid misuse; postnatal; pregnant; prenatal; protective factors; psychologic; racial and ethnic; recruit; remote assessment; socioeconomics; sound; stem; substance use; tool

Project Summary/Abstract Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD- NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi- modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state-of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.

项目总结/文摘