17/24 Healthy Brain and Child Development National Consortium
17/24 健康大脑和儿童发展国家联盟
基本信息
- 批准号:10378274
- 负责人:
- 金额:$ 100.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-09-30 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:10 year oldAddressAdverse eventAffectAlcoholsBehavioralBiologicalBirthBrainCOVID-19CaregiversChildChild DevelopmentCommunitiesComplementConceptionsDNADataData CollectionData Coordinating CenterData SetDevelopmentEnrollmentEnvironmentEnvironmental ExposureEnvironmental HazardsEpigenetic ProcessEthicsEventExposure toFeedbackGeneral PopulationGenesGoalsHealthHumanInfantInfectionLifeLinkLocationMalnutritionMarijuanaMaternal HealthMeasuresMethodsModalityMonitorMothersNewborn InfantOpioidOutcomeParticipantPersonsPhysiologicalPopulationPregnancyPregnant WomenProcessProtocols documentationPsychopathologyPublic PolicyResearchResearch DesignResearch PersonnelSamplingSecond Pregnancy TrimesterSeveritiesShapesSiteStressStructural RacismTimeTime StudyTobaccoToxicant exposureTrainingUnited StatesWomanWorkbasecaregivingchild bearingcohortcritical perioddata harmonizationdata integritydata standardsdesignearly experienceearly life exposureexperiencehazardhigh dimensionalityimprovedinnovationinsightmagnetic resonance imaging/electroencephalographymaltreatmentmaternal stressmultimodalityneurodevelopmentneuroimagingnovelpostnatalpregnantprenatalprotective factorspsychologicracial and ethnicrecruitsocioeconomicssoundsubstance usetool
项目摘要
Project Summary/Abstract
Neurodevelopmental processes are shaped by dynamic interactions between genes and environments.
Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring
developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant
exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment,
structural racism, and excessive stress. To elucidate how various environmental hazards impact child
development, it is imperative that a normative template of developmental trajectories over the first 10 years of
life be established based on a sufficiently large and demographically diverse sample of the US population. To
accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed
to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented
by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand
neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the
United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD-
NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research
dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center
(HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high-
dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will
assess how biological and environmental exposures affect those trajectories. A special emphasis will be
placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco
and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a
racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2)
pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3)
demographically and behaviorally similar women without substance use in pregnancy to enable valid causal
inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and
protective environments have the most influence on later neurodevelopmental outcomes. The large, multi-
modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide
novel insights into child development using state-of-the-art methods. The HBCD-NC study will inform public
policy to improve the health and development of children across the nation.
项目概要/摘要
神经发育过程是由基因和环境之间的动态相互作用决定的。
生命早期的适应不良经历会改变发育轨迹,导致有害和持久的
发育后遗症。产前和产后危害包括母体物质暴露、有毒物质
怀孕和早年接触、孕产妇健康状况、父母精神病理学、虐待、
结构性种族主义和过度压力。阐明各种环境危害如何影响儿童
为实现发展,必须制定前 10 年发展轨迹的规范模板
生活的建立是基于足够大且人口多样化的美国人口样本。到
为了实现这一目标,健康大脑和儿童发展国家联盟 (HBCD-NC) 已经成立
部署一套协调、优化和创新的神经影像(MRI、EEG)措施作为补充
通过一系列广泛的行为、生理和心理工具以及生物样本来了解
在全国 24 个地点招募的 7,500 名母亲和婴儿样本中的神经发育轨迹
美国(US)。 HBCD-NC 将在 HBCD-NC 的指导下开展共同研究方案
NC 行政核心 (HCAC) 将收集和分发全面且精心策划的研究
在 HBCD-NC 数据协调中心的指导下向整个科学界提供数据集
(HDCC)。 HBCD-NC 的总体目标是创建一个全面、协调和高水平的
维度数据集将描述美国儿童的典型神经发育轨迹,并且将
评估生物和环境暴露如何影响这些轨迹。将特别强调的是
致力于了解产前和产后接触阿片类药物、大麻、酒精、烟草的影响
和/或其他物质。为了实现这些广泛的目标,登记的女性样本将包括:1)
代表美国人口的种族、民族和社会经济多样化群体; 2)
使用目标物质(阿片类药物、大麻、酒精、烟草)的孕妇;和 3)
人口统计和行为相似的女性,在怀孕期间没有使用药物,以实现有效的因果关系
推论。此外,HBCD-NC 将确定关键的发展窗口,在此期间有害和
保护环境对以后的神经发育结果影响最大。大型、多
本研究首次产生的模态、纵向和可概括的数据集将提供
使用最先进的方法对儿童发展提出新颖的见解。 HBCD-NC 研究将告知公众
改善全国儿童健康和发展的政策。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Michael K. Georgieff其他文献
Effect of postnatal steroid administration on serum vitamin A concentrations in newborn infants with respiratory compromise.
出生后类固醇给药对患有呼吸系统损害的新生儿血清维生素 A 浓度的影响。
- DOI:
- 发表时间:
1989 - 期刊:
- 影响因子:3.3
- 作者:
Michael K. Georgieff;Michael K. Georgieff;M. Mammel;M. Mammel;M. Mills;M. Mills;Elaine W. Gunter;E. Gunter;Dana E. Johnson;Dana E. Johnson;Thompson Tr;Thompson Tr - 通讯作者:
Thompson Tr
Mid-arm circumference and mid-arm/head circumference ratios: Standard curves for anthropometric assessment of neonatal nutritional status
- DOI:
10.1016/s0022-3476(86)80393-6 - 发表时间:
1986-08-01 - 期刊:
- 影响因子:
- 作者:
Sharon R. Sasanow;Michael K. Georgieff;Gilberto R. Pereira - 通讯作者:
Gilberto R. Pereira
Effects of selective phosphodiesterase 3 inhibition in the perfused liver of the rat after endotoxin treatment
内毒素处理后选择性磷酸二酯酶3抑制对大鼠灌注肝脏的影响
- DOI:
- 发表时间:
1996 - 期刊:
- 影响因子:7.3
- 作者:
Hans Weidenbach;K. Beckh;T. Schricker;Michael K. Georgieff;Gail K. Adler;M. Burger - 通讯作者:
M. Burger
INCREASED PLACENTAL IRON-RESPONSIVE PROTEIN-1 (IRP-1) AND TRANSFERRIN RECEPTOR (TfR) mRNA IN DIABETIC PREGNANCIES COMPLICATED BY FETAL IRON DEFICIENCY † 248
糖尿病合并胎儿缺铁性贫血的孕妇胎盘铁反应蛋白-1(IRP-1)和转铁蛋白受体(TfR)mRNA 表达增加†248
- DOI:
10.1203/00006450-199704001-00268 - 发表时间:
1997-04-01 - 期刊:
- 影响因子:3.100
- 作者:
Michael K. Georgieff;Elizabeth A. Liebold;Jane D. Wobken;Susan A. Berry - 通讯作者:
Susan A. Berry
The importance of iron deficiency in pregnancy on fetal, neonatal, and infant neurodevelopmental outcomes.
- DOI:
10.1002/ijgo.14951 - 发表时间:
2023-08 - 期刊:
- 影响因子:0
- 作者:
Michael K. Georgieff - 通讯作者:
Michael K. Georgieff
Michael K. Georgieff的其他文献
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{{ truncateString('Michael K. Georgieff', 18)}}的其他基金
17/24 Healthy Brain and Child Development National Consortium
17/24 健康大脑和儿童发展国家联盟
- 批准号:
10661762 - 财政年份:2021
- 资助金额:
$ 100.1万 - 项目类别:
17/24 Healthy Brain and Child Development National Consortium
17/24 健康大脑和儿童发展国家联盟
- 批准号:
10494131 - 财政年份:2021
- 资助金额:
$ 100.1万 - 项目类别:
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施
- 批准号:
10666452 - 财政年份:2015
- 资助金额:
$ 100.1万 - 项目类别:
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施
- 批准号:
10250653 - 财政年份:2015
- 资助金额:
$ 100.1万 - 项目类别:
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施
- 批准号:
9274124 - 财政年份:2015
- 资助金额:
$ 100.1万 - 项目类别:
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施
- 批准号:
10295935 - 财政年份:2015
- 资助金额:
$ 100.1万 - 项目类别:
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