Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders

补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施

基本信息

  • 批准号:
    10295935
  • 负责人:
  • 金额:
    $ 59.63万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-08-15 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY / ABSTRACT Fetal alcohol spectrum disorders (FASDs) comprise a range of effects resulting from prenatal alcohol exposure (PAE) including neurological abnormalities, cognitive and behavioral impairments, growth retardation, and craniofacial anomalies. Few treatments have been investigated despite FASD’s tremendous public health burden. Cognitive deficits are a core feature of FASD, and cognition is a natural target for intervention. One potential intervention for cognition in FASD is the essential nutrient choline - known to have effects on brain development and cognition. In the hippocampus, choline contributes to increased dendritic arborization, larger cells, and functional changes. Choline affects the cholinergic system and alters brain structure and function in regions essential for memory functioning, including methylation in the hippocampus and prefrontal cortex. Only a handful of human choline studies for FASD have been undertaken and our group has conducted most of them. Our early double-blind, randomized, controlled trial established safety and tolerability. Our subsequent trial revealed beneficial effects for sequential delayed memory in participants with FASD (greater in younger [ages 2-3] rather than older [ages 3-5] children). Our third (ongoing) study included a long- term follow-up that demonstrated long-term benefits for choline vs. placebo in non-verbal processing, working memory, long-term verbal memory, and ADHD behavior. The proposed studies will include a new clinical trial with a new cohort of 2-5 year old children with FASD. Rather than a placebo- controlled trial, it will be a two-arm block-randomized study with cumulative choline exposure durations of 3 or 6 months. Results will directly inform future clinical implementation of choline as a neurodevelopmental intervention. The proposed studies will also capitalize on three existing cohorts for additional longitudinal studies that will determine durability of effects from early treatment. A 4- year and 8-year follow-up study will each examine cognitive effects as well as structural and functional brain effects using advanced MRI methods. Cognitive measures will include the Stanford- Binet Intelligence Scale, the Elicited Imitation memory test, the NIH Toolbox Flanker test and Picture Sequence Memory Test, and the Minnesota Executive Function Scale. We will examine choline effects on behavior using parent-report (CBCL) and a structured diagnostic interview (KSADS). Select hippocampal sub-fields will be examined for volumetric improvements following choline or placebo. Functional connectivity will be examined and is expected to reflect changes from early choline supplementation. We will also use cortical myelin mapping to evaluate choline’s effect on long-term myelin development. In addition, we will apply diffusion-weighted imaging to determine choline’s effect on white matter microstructure – which is known to be disrupted in FASD.
项目总结/摘要 胎儿酒精谱系障碍(FASD)包括产前酒精引起的一系列影响 暴露(CAE),包括神经系统异常、认知和行为障碍、生长 发育迟缓和颅面畸形尽管FASD的治疗方法很少, 巨大的公共卫生负担。认知缺陷是FASD的核心特征,而认知是FASD的一个重要特征。 自然是干预的对象。FASD认知的一种潜在干预是必要的, 营养胆碱-已知对大脑发育和认知有影响。在海马体中, 胆碱有助于增加树突状分支、更大的细胞和功能变化。胆碱 影响胆碱能系统,改变大脑结构和记忆关键区域的功能 功能,包括海马体和前额皮质的甲基化。只有少数人类 胆碱对FASD的研究已经进行,我们的小组进行了其中的大部分。我们 早期的双盲、随机、对照试验确定了安全性和耐受性。我们随后 一项试验显示,FASD参与者的顺序延迟记忆( 年龄较小[2-3岁]而不是年龄较大[3-5岁]的儿童)。我们的第三项(正在进行的)研究包括一项长期的- 长期随访表明胆碱与安慰剂相比在非语言处理方面具有长期益处, 工作记忆、长期非文字记忆和ADHD行为。拟议的研究将包括 一项针对2-5岁FASD儿童新队列的新临床试验。不是安慰剂- 对照试验,这将是一项具有累积胆碱暴露的双臂区组随机研究 持续时间为3或6个月。结果将直接告知未来胆碱作为一种 神经发育干预拟议的研究还将利用现有的三个队列 进行额外的纵向研究,以确定早期治疗效果的持久性。A 4- 一年和8年的随访研究将分别检查认知效果以及结构和 大脑功能的影响。认知测量将包括斯坦福大学- Binet智力量表、诱发模仿记忆测验、NIH Flanker测验和图片测验 序列记忆测试和明尼苏达执行功能量表。我们会检查胆碱 使用父母报告(CBCL)和结构化诊断访谈(KSADS)对行为的影响。 将检查选择的海马子野,以确定胆碱或 安慰剂将检查功能连接,并预计将反映早期的变化 胆碱补充剂我们还将使用皮层髓鞘映射来评估胆碱对神经元的影响。 长期髓鞘发育。此外,我们将应用弥散加权成像来确定 胆碱对白色物质微观结构的影响-已知在FASD中被破坏。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Michael K. Georgieff其他文献

Effect of postnatal steroid administration on serum vitamin A concentrations in newborn infants with respiratory compromise.
出生后类固醇给药对患有呼吸系统损害的新生儿血清维生素 A 浓度的影响。
  • DOI:
  • 发表时间:
    1989
  • 期刊:
  • 影响因子:
    3.3
  • 作者:
    Michael K. Georgieff;Michael K. Georgieff;M. Mammel;M. Mammel;M. Mills;M. Mills;Elaine W. Gunter;E. Gunter;Dana E. Johnson;Dana E. Johnson;Thompson Tr;Thompson Tr
  • 通讯作者:
    Thompson Tr
Mid-arm circumference and mid-arm/head circumference ratios: Standard curves for anthropometric assessment of neonatal nutritional status
  • DOI:
    10.1016/s0022-3476(86)80393-6
  • 发表时间:
    1986-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Sharon R. Sasanow;Michael K. Georgieff;Gilberto R. Pereira
  • 通讯作者:
    Gilberto R. Pereira
Effects of selective phosphodiesterase 3 inhibition in the perfused liver of the rat after endotoxin treatment
内毒素处理后选择性磷酸二酯酶3抑制对大鼠灌注肝脏的影响
  • DOI:
  • 发表时间:
    1996
  • 期刊:
  • 影响因子:
    7.3
  • 作者:
    Hans Weidenbach;K. Beckh;T. Schricker;Michael K. Georgieff;Gail K. Adler;M. Burger
  • 通讯作者:
    M. Burger
INCREASED PLACENTAL IRON-RESPONSIVE PROTEIN-1 (IRP-1) AND TRANSFERRIN RECEPTOR (TfR) mRNA IN DIABETIC PREGNANCIES COMPLICATED BY FETAL IRON DEFICIENCY † 248
糖尿病合并胎儿缺铁性贫血的孕妇胎盘铁反应蛋白-1(IRP-1)和转铁蛋白受体(TfR)mRNA 表达增加†248
  • DOI:
    10.1203/00006450-199704001-00268
  • 发表时间:
    1997-04-01
  • 期刊:
  • 影响因子:
    3.100
  • 作者:
    Michael K. Georgieff;Elizabeth A. Liebold;Jane D. Wobken;Susan A. Berry
  • 通讯作者:
    Susan A. Berry

Michael K. Georgieff的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Michael K. Georgieff', 18)}}的其他基金

17/24 Healthy Brain and Child Development National Consortium
17/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10661762
  • 财政年份:
    2021
  • 资助金额:
    $ 59.63万
  • 项目类别:
17/24 Healthy Brain and Child Development National Consortium
17/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10494131
  • 财政年份:
    2021
  • 资助金额:
    $ 59.63万
  • 项目类别:
17/24 Healthy Brain and Child Development National Consortium
17/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10378274
  • 财政年份:
    2021
  • 资助金额:
    $ 59.63万
  • 项目类别:
Newborn iron deficiency
新生儿缺铁
  • 批准号:
    10447782
  • 财政年份:
    2018
  • 资助金额:
    $ 59.63万
  • 项目类别:
Newborn iron deficiency
新生儿缺铁
  • 批准号:
    10217214
  • 财政年份:
    2018
  • 资助金额:
    $ 59.63万
  • 项目类别:
Newborn iron deficiency
新生儿缺铁
  • 批准号:
    9980703
  • 财政年份:
    2018
  • 资助金额:
    $ 59.63万
  • 项目类别:
Newborn iron deficiency
新生儿缺铁
  • 批准号:
    9762150
  • 财政年份:
    2018
  • 资助金额:
    $ 59.63万
  • 项目类别:
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施
  • 批准号:
    10666452
  • 财政年份:
    2015
  • 资助金额:
    $ 59.63万
  • 项目类别:
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施
  • 批准号:
    10250653
  • 财政年份:
    2015
  • 资助金额:
    $ 59.63万
  • 项目类别:
Choline Supplementation as a Neurodevelopmental Intervention in Fetal Alcohol Spectrum Disorders
补充胆碱作为胎儿酒精谱系障碍的神经发育干预措施
  • 批准号:
    9274124
  • 财政年份:
    2015
  • 资助金额:
    $ 59.63万
  • 项目类别:

相似海外基金

The Language Environment in Fostering 5-Year-Old Children's Voluntary Involvements
培养5岁儿童自愿参与的语言环境
  • 批准号:
    22K13681
  • 财政年份:
    2022
  • 资助金额:
    $ 59.63万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
The Study of Reading Picture Books In 5-Year-Old Class and the Support Process of the Teachers
五岁班绘本阅读研究及教师支持过程
  • 批准号:
    19K14156
  • 财政年份:
    2019
  • 资助金额:
    $ 59.63万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Improving motor skills in 3-5 year old children with Autism Spectrum Disorder: Effects on the family unit.
提高患有自闭症谱系障碍的 3-5 岁儿童的运动技能:对家庭单位的影响。
  • 批准号:
    386469
  • 财政年份:
    2017
  • 资助金额:
    $ 59.63万
  • 项目类别:
    Studentship Programs
Epidemiological study and Creating new diagnostic methods for Neurodevelopmental disorders in 5-year-old children
5岁儿童神经发育障碍流行病学研究及诊断新方法
  • 批准号:
    16K10239
  • 财政年份:
    2016
  • 资助金额:
    $ 59.63万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Differences in motor milestone attainment in 4- and 5-year old children at risk for Developmental Coordination Disorder
有发育协调障碍风险的 4 岁和 5 岁儿童在运动里程碑方面的差异
  • 批准号:
    324425
  • 财政年份:
    2015
  • 资助金额:
    $ 59.63万
  • 项目类别:
Prevalence and social determinants of developmental outcomes among 5-year-old children with health disorders: A Pan-Canadian study
5 岁儿童健康障碍的患病率和发育结果的社会决定因素:一项泛加拿大研究
  • 批准号:
    322111
  • 财政年份:
    2015
  • 资助金额:
    $ 59.63万
  • 项目类别:
    Operating Grants
Fornative Expressive Behavior in Children's (4 years old and 5 year-old) Artistic Play Activities
儿童(4岁和5岁)艺术游戏活动中的本能表达行为
  • 批准号:
    26780506
  • 财政年份:
    2014
  • 资助金额:
    $ 59.63万
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
The development which is a shift support program to a 1st grader of elementary school from 5-year old children who prevents "a 1st grade of elementary school, problem"
作为防止"小学一年级、问题"的5岁儿童到小学一年级学生的轮班支援计划的展开
  • 批准号:
    25381292
  • 财政年份:
    2013
  • 资助金额:
    $ 59.63万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Development of behavioural measures of sentence comprehension in 2 to 5 year old children
2至5岁儿童句子理解行为测量的发展
  • 批准号:
    449402-2013
  • 财政年份:
    2013
  • 资助金额:
    $ 59.63万
  • 项目类别:
    University Undergraduate Student Research Awards
Technology development and neuroimaging for 5 year old children with HIV infectio
5 岁 HIV 感染儿童的技术开发和神经影像学
  • 批准号:
    8333355
  • 财政年份:
    2011
  • 资助金额:
    $ 59.63万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了