DEVELOPMENTAL EFFECTS OF EARLY IRON DEFICIENCY IN RATS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 Prime授予头衔：早期缺铁的行为，Prime Pi：Betsy Lozoff，MD 密歇根大学人类生长与发展中心，密歇根州安娜堡 妊娠期和出生后早期缺铁在人类中很常见，并导致行为改变，暗示有纹状体功能障碍。相反，铁超载被认为在神经退行性变中起着重要作用。本项目的目的是通过动物模型研究缺铁和铁治疗对发育中的大脑的影响。早期缺铁改变了发育中的纹状体的神经化学特征，并解释了纹状体依赖行为的异常。铁缺乏和铁充足的幼鼠的纹状体脑代谢产物是非侵入性定量的，不同剂量的铁补充的效果将在9.4T下用~1H核磁共振波谱测定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prime grant title: Behavior in Early Iron Deficiency, Prime PI: Betsy Lozoff, MD Center for Human Growth and Development, University of Michigan, Ann Arbor, MI Gestational and early postnatal iron deficiency occurs commonly in humans and results in altered behaviors suggestive of striatal dysfunction. Conversely, iron overload has been proposed to play a significant role in neurodegeneration. The purpose of this project is to investigate the effect of the iron deficiency and iron treatment on the developing brain using an animal model. Early iron deficiency alters the neurochemical profile of the developing striatum and accounts for abnormalities in striatum-dependent behavior in rats. Brain metabolite are non-invasively quantified from striatum of iron-deficient and iron-sufficient rat pups and the effects of different doses of iron supplementation will be determined using 1H NMR spectroscopy at 9.4T.