Enabling Rapid and Accurate Identification of Emerging Vector-Borne and Zoonotic Threats in Indonesia

项目摘要 人畜共患病占全球新发人类疾病的至少75%。印度尼西亚 已被确定为主要新兴病原体“热点”之一， 在缺乏可靠的 整个印尼的检测系统都很高。通过检测和表征 印度尼西亚新出现的媒介传播和人畜共患病病原体项目，我们将认识到 并识别这些事件，并迅速检测病原体的传播， 对印度尼西亚人口的潜在流行病。在我们现有的CK 15 -001中，我们 在艾克曼研究所建立了承认和查明 新出现的病原体，并试点使用这些技术来检测传播 在印度尼西亚的人口中。 本后续建议中的工作将为建立一个训练有素的 实验室工作人员，提供关于可能 在世界上人口第四多的国家出现并引起人类疾病， 并快速表征任何媒介传播的病原体的人类关注的循环， 国家这些目标的实现不仅会给公众健康带来直接的好处， 印度尼西亚，但将帮助推进全球卫生安全议程（GSHA） 通过评估突发事件了解美国人口面临的风险 在全球

Project Abstract Zoonoses account for at least 75% of emerging human diseases globally. Indonesia has been identified as one of the major emerging pathogen “hotspots” and the opportunities for an emergence event to become epidemic in the absence of a reliable detection system across Indonesia are high. Through Detection and Characterization of Emerging Vector-Borne and Zoonotic Pathogens in Indonesia project, we will recognize and identify these events and to rapidly detect the transmission of pathogens with pandemic potential to human populations in Indonesia. In our existing CK15-001, we have established capacity at the Eijkman Institute for recognition and identification of emerging pathogens and piloted the use of these technologies to detect the transmission to human populations in Indonesia. The work in this follow up proposal will lay the foundation for a network of trained laboratory personnel, provide baseline information on the vector-borne agents likely to emerge and cause human disease in the fourth most populated country in the world, and rapidly characterize any vector-borne pathogen of human concern circulating in the country. Completion of these aims will not only provide direct public health benefits to Indonesia, but will aid in advancing the Global Health Security Agenda (GSHA) objectives of understanding the risk to US populations by assessing emergence events globally.