权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Transdiagnostic Associations Across Developmental Disorders

发育障碍的跨诊断关联

基本信息

批准号：
10501785
负责人：
ELENA L GRIGORENKO
金额：
$ 63.75万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-09 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10501785
关键词：
14 year old Address Adolescent Adopted Africa Africa South of the Sahara African Area Asia Attitude Behavior Belief Biological Blindness Botswana Brain Caregivers Caring Catchment Area Characteristics Child Child Health Church Clinical Communities Community Services Country Data Data Set Detection Development Developmental Disabilities Diagnosis Differential Diagnosis Disease EEF1A2 gene Electroencephalography Ensure Etiology Event Family Fathers Focus Groups Funding Genetic Markers Genome Ghana Goals Head Health Health Services Health education Home Hospitals Household Income Individual Individuality Intellectual functioning disability Interview Kenya Link Literature Malawi Mission Monitor Mothers Namibia Nigerian Nongovernmental Organizations Pacifiers Pathway Analysis Pathway interactions Perception Personal Satisfaction Persons Phenotype Policy Maker Population Prevalence Province Public Health Punishment Radial Research Research Personnel Resources Rural Rural Community Sampling Schools Services Siblings Social Environment Source Structure Surveys Sustainable Development Tanzania Trust Typology United Nations United States National Institutes of Health Universities Witchcraft Work Zambia aged burden of illness child services childhood epilepsy developmental disease disability dynamic system early childhood functional near infrared spectroscopy girls healing health record hearing impairment human subject improved informant low and middle-income countries member neurophysiology physically handicapped policy recommendation proband recruit rural setting

项目摘要

SUMMARY The Global Burden of Disease (GBD) data of 2017 revealed that worldwide 291.2 million (11.2%) of 2.6 billion children and adolescents were estimated to have one of four developmental disabilities (childhood epilepsy, intellectual disability, and vision loss and hearing loss), which is an increase of more than double since 2004. Sub-Saharan Africa (SSA), along with South Asia, hosts the overwhelming majority (94.5%) of these children. These children, especially in SSA, are severely underrepresented in the relevant literature. The proposed work is intended to contribute to improving the representation of children and youth from SSA in the scientific literature. The overarching objective of this work is to identify and characterize children/youth (aged 3-18) with developmental disabilities (DD) growing up in rural Zambia. The proposed work is structured around three unique SA. SA1 pertains to the ascertainment of a large sample of children/youth with DD and their matched siblings (total n = 4,000). SA2 addresses the characterization of this sample of children to identify and classify the etiology and potential treatment of their DD. SA3 intends to document the services that are currently accessed by children/youth with DD, and to ascertain community perceptions of DD, to advise on what services are available, accessed, or needed. Collectively, SA1-3 will generate a unique multi-level (social context—behavior—brain—genome) dataset presenting a range of manifestations and causal pathways to DD in rural Zambia in particular and in SSA in general.

总结