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Transdiagnostic Associations Across Developmental Disorders

发育障碍的跨诊断关联

基本信息

批准号：
10501785
负责人：
ELENA L GRIGORENKO
金额：
$ 63.75万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-09 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10501785
关键词：
14 year old Address Adolescent Adopted Africa Africa South of the Sahara African Area Asia Attitude Behavior Belief Biological Blindness Botswana Brain Caregivers Caring Catchment Area Characteristics Child Child Health Church Clinical Communities Community Services Country Data Data Set Detection Development Developmental Disabilities Diagnosis Differential Diagnosis Disease EEF1A2 gene Electroencephalography Ensure Etiology Event Family Fathers Focus Groups Funding Genetic Markers Genome Ghana Goals Head Health Health Services Health education Home Hospitals Household Income Individual Individuality Intellectual functioning disability Interview Kenya Link Literature Malawi Mission Monitor Mothers Namibia Nigerian Nongovernmental Organizations Pacifiers Pathway Analysis Pathway interactions Perception Personal Satisfaction Persons Phenotype Policy Maker Population Prevalence Province Public Health Punishment Radial Research Research Personnel Resources Rural Rural Community Sampling Schools Services Siblings Social Environment Source Structure Surveys Sustainable Development Tanzania Trust Typology United Nations United States National Institutes of Health Universities Witchcraft Work Zambia aged burden of illness child services childhood epilepsy developmental disease disability dynamic system early childhood functional near infrared spectroscopy girls healing health record hearing impairment human subject improved informant low and middle-income countries member neurophysiology physically handicapped policy recommendation proband recruit rural setting

项目摘要

SUMMARY The Global Burden of Disease (GBD) data of 2017 revealed that worldwide 291.2 million (11.2%) of 2.6 billion children and adolescents were estimated to have one of four developmental disabilities (childhood epilepsy, intellectual disability, and vision loss and hearing loss), which is an increase of more than double since 2004. Sub-Saharan Africa (SSA), along with South Asia, hosts the overwhelming majority (94.5%) of these children. These children, especially in SSA, are severely underrepresented in the relevant literature. The proposed work is intended to contribute to improving the representation of children and youth from SSA in the scientific literature. The overarching objective of this work is to identify and characterize children/youth (aged 3-18) with developmental disabilities (DD) growing up in rural Zambia. The proposed work is structured around three unique SA. SA1 pertains to the ascertainment of a large sample of children/youth with DD and their matched siblings (total n = 4,000). SA2 addresses the characterization of this sample of children to identify and classify the etiology and potential treatment of their DD. SA3 intends to document the services that are currently accessed by children/youth with DD, and to ascertain community perceptions of DD, to advise on what services are available, accessed, or needed. Collectively, SA1-3 will generate a unique multi-level (social context—behavior—brain—genome) dataset presenting a range of manifestations and causal pathways to DD in rural Zambia in particular and in SSA in general.

总结 2017年全球疾病负担（GBD）数据显示，全球26亿人中有2.912亿人（11.2%）儿童和青少年估计有四种发育障碍之一（儿童癫痫，智力残疾、视力丧失和听力丧失），自2004年以来增加了一倍多。撒哈拉以南非洲（SSA）沿着南亚收容了绝大多数（94.5%）这些儿童。这些儿童，特别是撒哈拉以南非洲的儿童，在相关文献中的代表性严重不足。拟议工作旨在促进提高撒南非洲儿童和青年在科学领域的代表性，文学这项工作的总体目标是查明儿童/青年（3-18岁）的特点患有发育性残疾的儿童。拟议的工作围绕三个方面展开独特的SA。SA 1涉及确定DD儿童/青少年的大样本及其匹配兄弟姐妹（总计n = 4，000）。SA 2解决了这一儿童样本的特点，以确定和分类其DD的病因和潜在治疗。SA 3旨在记录当前儿童/青少年与DD接触，并确定社区对DD的看法，服务是可用的、可访问的或需要的。总的来说，SA 1 -3将产生一个独特的多层次（社会上下文-行为-大脑-基因组）数据集呈现了DD的一系列表现和因果途径特别是在赞比亚农村地区和整个撒南非洲。