Transdiagnostic Associations Across Developmental Disorders

发育障碍的跨诊断关联

基本信息

批准号：
10701008
负责人：
ELENA L GRIGORENKO
金额：
$ 65.87万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-09 至 2027-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10701008
关键词：
14 year old Address Adolescent Adopted Africa Africa South of the Sahara African Area Asia Attitude Behavior Belief Biological Blindness Botswana Brain Caregivers Caring Catchment Area Characteristics Child Child Health Church Classification Clinical Communities Community Services Country Data Data Set Dedications Detection Development Developmental Disabilities Diagnosis Diagnostic Differential Diagnosis Disease EEF1A2 gene Electroencephalography Ensure Etiology Event Family Fathers Focus Groups Funding Genetic Markers Genome Ghana Goals Health Health Services Health education Home Hospital Administration Hospitals Household Income Individual Individuality Intellectual functioning disability Interview Kenya Link Literature Malawi Mission Monitor Mothers Namibia Nigerian Pacifiers Pathway Analysis Pathway interactions Perception Personal Satisfaction Persons Phenotype Policy Maker Population Prevalence Province Public Health Punishment Radial Research Research Personnel Resources Rural Rural Community Sampling Schools Services Siblings Social Environment Source Structure Surveys Sustainable Development Tanzania Trust Typology United Nations United States National Institutes of Health Universities Witchcraft Work Youth Zambia Zimbabwe aged burden of illness child services childhood epilepsy developmental disease disability dynamic system early childhood functional near infrared spectroscopy girls health record hearing impairment human subject improved informant low and middle-income countries member neurophysiology physically handicapped policy recommendation proband recruit remediation rural setting social stigma

项目摘要

SUMMARY The Global Burden of Disease (GBD) data of 2017 revealed that worldwide 291.2 million (11.2%) of 2.6 billion children and adolescents were estimated to have one of four developmental disabilities (childhood epilepsy, intellectual disability, and vision loss and hearing loss), which is an increase of more than double since 2004. Sub-Saharan Africa (SSA), along with South Asia, hosts the overwhelming majority (94.5%) of these children. These children, especially in SSA, are severely underrepresented in the relevant literature. The proposed work is intended to contribute to improving the representation of children and youth from SSA in the scientific literature. The overarching objective of this work is to identify and characterize children/youth (aged 3-18) with developmental disabilities (DD) growing up in rural Zambia. The proposed work is structured around three unique SA. SA1 pertains to the ascertainment of a large sample of children/youth with DD and their matched siblings (total n = 4,000). SA2 addresses the characterization of this sample of children to identify and classify the etiology and potential treatment of their DD. SA3 intends to document the services that are currently accessed by children/youth with DD, and to ascertain community perceptions of DD, to advise on what services are available, accessed, or needed. Collectively, SA1-3 will generate a unique multi-level (social context—behavior—brain—genome) dataset presenting a range of manifestations and causal pathways to DD in rural Zambia in particular and in SSA in general.

概括 2017年的全球疾病负担（GBD）数据显示，全球2.912亿（11.2％）的26亿据估计，儿童和青少年患有四种发育障碍之一（儿童癫痫，智力残疾，视力丧失和听力损失），自2004年以来，这是一倍以上的增加。撒哈拉以南非洲（SSA）与南亚共同拥有这些儿童的绝大多数（94.5％）。这些孩子，尤其是在SSA中，在相关文献中的代表性严重不足。拟议的工作旨在为改善SSA的儿童和青少年的代表做出贡献文学。这项工作的总体目标是确定和表征儿童/青年（3-18岁）在赞比亚农村长大的发育障碍（DD）。拟议的工作是大约三个独特的SA。 SA1与确定大量DD儿童/青少年及其匹配有关兄弟姐妹（总n = 4,000）。 SA2解决了此儿童样本以识别和分类的表征其DD的病因和潜在处理。 SA3打算记录当前的服务由患有DD的儿童/青少年访问，并确定社区对DD的看法，以建议什么服务可用，访问或需要。总体而言，SA1-3将产生独特的多层次（社会上下文 - 行为 - 脑 - 基因组）数据集，呈现了一系列表现形式和因果关系途径尤其是赞比亚，通常在SSA中。