Transdiagnostic Associations Across Developmental Disorders

总结 2017年全球疾病负担（GBD）数据显示，全球26亿人中有2.912亿人（11.2%） 儿童和青少年估计有四种发育障碍之一（儿童癫痫， 智力残疾、视力丧失和听力丧失），自2004年以来增加了一倍多。 撒哈拉以南非洲（SSA）沿着南亚是这些儿童的绝大多数（94.5%）。 这些儿童，特别是撒哈拉以南非洲的儿童，在相关文献中的代表性严重不足。拟议工作 旨在促进提高撒南非洲儿童和青年在科学领域的代表性， 文学这项工作的总体目标是查明儿童/青年（3-18岁）的特点 患有发育性残疾的儿童。拟议的工作围绕三个方面展开 独特的SA。SA 1涉及确定DD儿童/青少年及其匹配的大样本 兄弟姐妹（总计n = 4，000）。SA 2解决了这一儿童样本的特点，以确定和分类 其DD的病因和潜在治疗。SA 3旨在记录当前 儿童/青少年与DD接触，并确定社区对DD的看法， 服务是可用的、可访问的或需要的。总的来说，SA 1 -3将产生一个独特的多层次（社会 上下文-行为-脑-基因组）数据集，其呈现DD的一系列表现和因果途径 特别是在赞比亚农村地区和整个撒南非洲。

SUMMARY The Global Burden of Disease (GBD) data of 2017 revealed that worldwide 291.2 million (11.2%) of 2.6 billion children and adolescents were estimated to have one of four developmental disabilities (childhood epilepsy, intellectual disability, and vision loss and hearing loss), which is an increase of more than double since 2004. Sub-Saharan Africa (SSA), along with South Asia, hosts the overwhelming majority (94.5%) of these children. These children, especially in SSA, are severely underrepresented in the relevant literature. The proposed work is intended to contribute to improving the representation of children and youth from SSA in the scientific literature. The overarching objective of this work is to identify and characterize children/youth (aged 3-18) with developmental disabilities (DD) growing up in rural Zambia. The proposed work is structured around three unique SA. SA1 pertains to the ascertainment of a large sample of children/youth with DD and their matched siblings (total n = 4,000). SA2 addresses the characterization of this sample of children to identify and classify the etiology and potential treatment of their DD. SA3 intends to document the services that are currently accessed by children/youth with DD, and to ascertain community perceptions of DD, to advise on what services are available, accessed, or needed. Collectively, SA1-3 will generate a unique multi-level (social context—behavior—brain—genome) dataset presenting a range of manifestations and causal pathways to DD in rural Zambia in particular and in SSA in general.