Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care

用于创伤护理的基于钙钛矿的可折叠灵敏 X 射线成像探测器

• 批准号: 10502805
• 负责人: Jinsong Huang
• 金额: $ 33.89万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10502805
• 关键词: Address; Adhesives; Area; Cancer Etiology; Cancer Patient; Ceramics; Cerium; Characteristics; Charge; DNA Damage; Data Collection; Detection; Development; Devices; Diagnosis; Diagnostic Equipment; Dose; Electrodes; Electronics; Electrons; Environment; Exposure to; Film; Generations; Glues; Hospitals; Image; Imaging Device; Imaging Techniques; Individual; Injury; Ionizing radiation; Lead; Mammography; Mechanics; Medical Imaging; Membrane; Metals; Nature; Noise; Nylons; Oxidants; Paste substance; Patient imaging; Patients; Pattern; Play; Polymers; Positioning Attribute; Process; Radiation; Radiation-Induced Cancer; Research; Resolution; Roentgen Rays; Role; Semiconductors; Signal Transduction; Silver; Solvents; Speed; Strontium; Structure; Techniques; Technology; Time; X-Ray Computed Tomography; X-Ray Medical Imaging; Yoga; automobile accident; base; cancer risk; clinical diagnostics; cost; design; detector; flexibility; imager; imaging detector; imaging facilities; imaging modality; improved; ionization; light emission; light weight; particle; perovskite; point of care; portability; practical application; radiation risk; response; screening; simulation; tomosynthesis; trauma care

Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care Project Summary/Abstract X-ray imaging techniques including plain x-ray, tomosynthesis and computed tomography are the most common and indispensable imaging modalities for screening and diagnosis. Trauma care needs the rapid deployment of medical diagnostic devices and data collection to examine the injury of patient in complicated environments, such as outside the hospitals or imaging-centers. Portable medical imaging devices such as X- ray imaging devices are notably critical to address these needs. Since almost all present X-ray detectors are made of the combination of scintillators with photodetector arrays, the portability of X-ray detectors is limited by the rigid ceramic scintillators. Exposure to ionizing radiation is known to increase the risk of cancer due to the damaging of DNA by X-ray. The current detectors are not sensitive enough so that a large dose is need to achieve enough signal to noise ratio in imaging. The overall objective of this project is to yield a new generation of X-ray detectors that are foldable, sensitive by overcoming the limitation of state-of-the-art detectors using metal halide perovskites to directly convert X-ray into electrical signal. Direct conversion detectors have better resolution than indirection ones, because it doesnot have the issue of nondirectional light emission in scintillators. Perovskites are promising X-ray detection material by combining the strong stopping to X-ray and excellent charge extraction capability. These detectors will be made to be like Yoga mats so that they can be folded for easy carrying and quickly rolling-out or wrapping the point of care for inspection. A perovskite filled membrane (PFM) structure will be used for multiple layer structure construction which have been demonstrated to have the high sensitivity and easy to upscaled to large area for practical applications. Our specific objectives are: (Aim1) establishing perovskite compositions, stacking structure and material fabrication process to develop sensitive PFMs with large mobility-lifetime product, low noise, and excellent uniformity over a practical X-ray imaging device area; (Aim2) developing a material design and process to integrate the X-ray detection perovskite films into readout electronics with a robust mechanical connection and uniform electronic connection using several soft materials based bonding techniques, The proposed technology has the potential to offer: (1) a factor of 10- 100 X patient imaging dose reduction; (2) increased imaging resolution; and (3) a flexibility and light weight detector. The project leverages a recently discovered application of lead halide perovskites for ionization radiation detection with demonstrated significantly higher sensitivity compared to the current mammography detectors; Reducing the imaging dose will decrease the risk of radiation-induced cancer for patients, making the screening process safer. Increasing the resolution will potentially lead to improved detection and analysis of features in injury or sickness. The light-weight foldable detectors enable new applications in field for trauma care.

用于创伤护理的钙钛矿基可折叠和灵敏的X射线成像探测器 项目摘要/摘要 X射线成像技术包括普通x射线、层析合成和计算机层析成像 用于筛查和诊断的常见和不可或缺的成像方式。创伤护理需要快速 部署医疗诊断设备和数据采集检查复杂患者的损伤 环境，如医院或影像中心外。便携式医学成像设备，如X- 射线成像设备对于满足这些需求至关重要。由于目前几乎所有的X射线探测器都是 由闪烁体和光电探测器阵列组合而成的X射线探测器的便携性受到以下限制 坚硬的陶瓷闪烁体。众所周知，暴露在电离辐射中会增加患癌症的风险，这是因为 X射线对DNA的损伤。目前的探测器不够灵敏，因此需要大剂量的 在成像中达到足够的信噪比。这个项目的总体目标是产生新一代 可折叠、灵敏的X射线探测器克服了最先进的探测器使用 金属卤化物钙钛矿直接将X射线转换为电信号。直接转换检测器有更好的 分辨率优于间接分辨率，因为它不存在闪烁体无方向光发射的问题。 钙钛矿材料结合了对X射线的强阻挡和优异的性能，是一种很有前途的X射线探测材料 电荷提取能力。这些探测器将被制作成像瑜伽垫一样，这样它们就可以折叠起来 便于携带，可快速展开或包裹看护点，便于检查。钙钛矿型填充膜 (PFM)结构将用于多层结构建筑，已被证明具有 灵敏度高，易于大面积升级，便于实际应用。我们的具体目标是：(Aim1) 确定钙钛矿成分、堆积结构和材料制备工艺以开发敏感材料 迁移率寿命积大、噪声低、在实际X射线成像中具有良好的均匀性的全息材料 设备领域；(AIM2)开发一种材料设计和工艺，以集成X射线探测钙钛矿薄膜 具有坚固的机械连接和统一的电子连接的读出电子设备使用 基于软材料的粘接技术，建议的技术有可能提供：(1)10- 100倍患者的成像剂量减少；(2)成像分辨率提高；(3)灵活性和重量轻 探测器。该项目利用最近发现的卤化铅钙钛矿电离应用 与目前的乳房X光检查相比，放射检测的灵敏度显著提高 探测器；减少成像剂量将降低患者患辐射诱发癌症的风险，使 筛查过程更安全。提高分辨率可能会改进对 在受伤或疾病方面的特征。轻质可折叠探测器使创伤护理领域有了新的应用。