Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care

用于创伤护理的基于钙钛矿的可折叠灵敏 X 射线成像探测器

• 批准号: 10650838
• 负责人: Jinsong Huang
• 金额: $ 33.89万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10650838
• 关键词: Address; Adhesives; Area; Cancer Etiology; Cancer Patient; Ceramics; Cerium; Characteristics; Charge; DNA Damage; Data Collection; Detection; Development; Devices; Diagnosis; Diagnostic Equipment; Dose; Electrodes; Electronics; Electrons; Environment; Exposure to; Film; Generations; Glues; Hospitals; Image; Imaging Device; Imaging Techniques; Individual; Injury; Ionizing radiation; Lead; Mammography; Mechanics; Medical Imaging; Membrane; Metals; Nature; Noise; Nylons; Paste substance; Patient imaging; Patients; Pattern; Play; Polymers; Positioning Attribute; Process; Radiation-Induced Cancer; Research; Resolution; Roentgen Rays; Role; Semiconductors; Signal Transduction; Silver; Solvents; Speed; Strontium; Structure; Techniques; Technology; X-Ray Computed Tomography; X-Ray Medical Imaging; Yoga; automobile accident; cancer risk; clinical diagnostics; cost; design; detector; fabrication; flexibility; imager; imaging detector; imaging facilities; imaging modality; improved; light emission; light weight; particle; perovskite; point of care; portability; practical application; radiation risk; response; screening; simulation; tomosynthesis; trauma care

Perovskite Based Foldable and Sensitive X-ray Imaging Detectors for Trauma Care Project Summary/Abstract X-ray imaging techniques including plain x-ray, tomosynthesis and computed tomography are the most common and indispensable imaging modalities for screening and diagnosis. Trauma care needs the rapid deployment of medical diagnostic devices and data collection to examine the injury of patient in complicated environments, such as outside the hospitals or imaging-centers. Portable medical imaging devices such as X- ray imaging devices are notably critical to address these needs. Since almost all present X-ray detectors are made of the combination of scintillators with photodetector arrays, the portability of X-ray detectors is limited by the rigid ceramic scintillators. Exposure to ionizing radiation is known to increase the risk of cancer due to the damaging of DNA by X-ray. The current detectors are not sensitive enough so that a large dose is need to achieve enough signal to noise ratio in imaging. The overall objective of this project is to yield a new generation of X-ray detectors that are foldable, sensitive by overcoming the limitation of state-of-the-art detectors using metal halide perovskites to directly convert X-ray into electrical signal. Direct conversion detectors have better resolution than indirection ones, because it doesnot have the issue of nondirectional light emission in scintillators. Perovskites are promising X-ray detection material by combining the strong stopping to X-ray and excellent charge extraction capability. These detectors will be made to be like Yoga mats so that they can be folded for easy carrying and quickly rolling-out or wrapping the point of care for inspection. A perovskite filled membrane (PFM) structure will be used for multiple layer structure construction which have been demonstrated to have the high sensitivity and easy to upscaled to large area for practical applications. Our specific objectives are: (Aim1) establishing perovskite compositions, stacking structure and material fabrication process to develop sensitive PFMs with large mobility-lifetime product, low noise, and excellent uniformity over a practical X-ray imaging device area; (Aim2) developing a material design and process to integrate the X-ray detection perovskite films into readout electronics with a robust mechanical connection and uniform electronic connection using several soft materials based bonding techniques, The proposed technology has the potential to offer: (1) a factor of 10- 100 X patient imaging dose reduction; (2) increased imaging resolution; and (3) a flexibility and light weight detector. The project leverages a recently discovered application of lead halide perovskites for ionization radiation detection with demonstrated significantly higher sensitivity compared to the current mammography detectors; Reducing the imaging dose will decrease the risk of radiation-induced cancer for patients, making the screening process safer. Increasing the resolution will potentially lead to improved detection and analysis of features in injury or sickness. The light-weight foldable detectors enable new applications in field for trauma care.

用于创伤护理的基于Percent的可折叠和灵敏的X射线成像探测器 项目总结/摘要 X射线成像技术，包括普通X射线，断层合成和计算机断层扫描是最 用于筛查和诊断的常见且不可或缺的成像模式。创伤护理需要快速 部署医疗诊断设备和数据收集，以检查复杂的病人的损伤， 例如在医院或成像中心之外。便携式医疗成像设备，如X-射线照相机， 射线成像设备对于满足这些需求是非常关键的。由于几乎所有现有的X射线探测器都是 由于X射线探测器是由闪烁器和光电探测器阵列组合而成的， 刚性陶瓷散热器。众所周知，暴露于电离辐射会增加患癌症的风险，因为 X射线对DNA的损伤目前的探测器灵敏度不够，因此需要大剂量来检测。 在成像中获得足够的信噪比。该项目的总体目标是产生新一代 X射线探测器是可折叠的，通过克服最先进的探测器的限制， 金属卤化物钙钛矿直接将X射线转换为电信号。直接转换探测器具有更好的 分辨率比间接的，因为它没有问题的非方向性光发射的反射器。 钙钛矿结合了对X射线的强阻挡和优异的探测性能，是一种很有前途的X射线探测材料 电荷提取能力。这些探测器将被做成瑜伽垫的样子，这样它们就可以折叠起来， 便于携带，并可快速展开或包裹护理点进行检查。一种钙钛矿填充膜， (PFM)结构将被用于多层结构的建设，已被证明有 灵敏度高，易于放大到大面积，便于实际应用。我们的具体目标是：（目标1） 建立钙钛矿组合物、堆叠结构和材料制造工艺， 在实际X射线成像中，具有大迁移率寿命积、低噪声和优异均匀性的PFM （Aim 2）开发材料设计和工艺以集成X射线检测钙钛矿膜 具有坚固的机械连接和均匀的电子连接， 基于软材料的键合技术，所提出的技术有可能提供：（1）10- 100 X患者成像剂量减少;（2）成像分辨率增加;（3）灵活性和重量轻 检测器该项目利用了最近发现的卤化铅钙钛矿电离应用 与当前乳房X线摄影相比，放射检测的灵敏度明显更高 降低成像剂量将降低患者辐射诱发癌症的风险， 筛选过程更安全。提高分辨率可能会改善对以下物质的检测和分析 受伤或生病的特征。轻型可折叠探测器使创伤护理领域的新应用成为可能。