Confirming the Effectiveness and Efficiency of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa
确认在线指导自助家庭治疗青少年神经性厌食症的有效性和效率
基本信息
- 批准号:10505414
- 负责人:
- 金额:$ 66.97万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-20 至 2027-07-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdolescentAdoptionAnorexia NervosaAttitudeBehaviorBlindedBody WeightCase SeriesChildClinicClinicalClinical TrialsCognitionDSM-VDataDisease remissionDivorceDoseEarly treatmentEatingEating DisordersEffectivenessFamilyFamily StudyFeasibility StudiesFundingHealth Services AccessibilityHealth systemHealthcare SystemsIncidenceIndividualIntentionInterventionInterviewMeasuresMediatingMediator of activation proteinMorbidity - disease rateObsessionOntarioOutcomeParentsPatient-Focused OutcomesPatientsPediatric HospitalsPersonsPilot ProjectsRandomizedReadingRecoveryResistanceSelf EfficacySeveritiesSingle ParentStructureTestingTimeTreatment EffectivenessTreatment outcomeVideo RecordingVideoconferencingWeightWeight GainYouthbasecomparative effectivenesscomparative effectiveness studycosteffective therapyeffectiveness testingefficacious treatmentempoweredevidence baseexperiencefamily structureflexibilityfollow-uphybrid type 1 designimplementation facilitatorsimprovedimproved outcomemortalitypreventive interventionprimary outcomereconstitutionrecruitresponsesecondary outcomeself helpservice interventionsevere mental illnesstreatment comparisontreatment effecttreatment programtreatment servicestreatment site
项目摘要
The application responds to PAR-21-130: Clinical Trials to Test the Effectiveness of Treatment, Prevention,
and Services Interventions. With an incidence rate of about 1%, Anorexia Nervosa (AN) is a serious mental
disorder associated with high mortality, morbidity and cost but becomes highly resistant once it has taken an
enduring course. The first-line treatment for adolescents with AN is Family Based Treatment (FBT), but is not
available to many patients. An effective strategy used with other eating disorders to address impediments to
scaling effective treatments is guided self-help (GSH) versions of efficacious treatments. We developed,
refined, and tested GSH-FBT in case series and pilot studies. Results of a multisite randomized feasibility
study comparing GSH-FBT to FBT-V found that both treatments were similarly acceptable to families with good
recruitment rates, low attrition rates, high completion rates of assessments, and were safe to deliver while
achieving similar improvements in eating related cognitions and weight. However, GSH-FBT achieved these
outcomes with greater efficiency (e.g., larger ratio of improvement in weight and cognitions to therapist
treatment time) by utilizing approximately 75% less therapist time than FBT-V. The main aim of this proposed
comparative effectiveness study is to confirm that clinical improvements in GSH-FBT are achieved with greater
efficiency than FBT-V in generalizable clinical settings. If this outcome is confirmed, it will lead to an increased
opportunity to utilize and scale an effective treatment for adolescent AN, promote increased access and
improve outcomes for these patients. We will also explore therapist attitudes toward GSH-FBT. To conduct this
study 200 adolescents with DSM-5 AN and their families will be randomized to either GSH-FBT or FBT-V in
two treatment sites (Stanford Children’s Hospital Eating Disorder Clinic and the Ontario Provincial Network of
Ministry-funded Specialized Treatment Services for Eating Disorders). The main outcome will be clinical
efficiency (the ratio of change in weight and eating related distorted cognitions to therapist time). Parental self-
efficacy will be assessed as a potential mediator of treatment effect. Family structure and severity of eating
related obsessions will be examined as moderators. Weights will be collected from session 1-4 to assess early
weight gain as a predictor of weight remission at the end of treatment (EOT). Data on therapists’ views of
GSH-FBT implementation will be collected by quantitative measures at BL and EOT, as well as by individual
semi-structured qualitative interviews. Both primary and secondary outcomes will be analyzed in line with the
intention to treat principle.
申请响应PAR-21-130:临床试验,以测试治疗,预防,
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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JAMES D LOCK其他文献
JAMES D LOCK的其他文献
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{{ truncateString('JAMES D LOCK', 18)}}的其他基金
Confirming the Effectiveness and Efficiency of Online Guided Self-Help Family-Based Treatment for Adolescent Anorexia Nervosa
确认在线指导自助家庭治疗青少年神经性厌食症的有效性和效率
- 批准号:
10707470 - 财政年份:2022
- 资助金额:
$ 66.97万 - 项目类别:
Confirming the Efficacy/Mechanism of Family Therapy for Children with Low Weight Avoidant/Restrictive Food Intake Disorder (ARFID)
确认家庭治疗对低体重回避/限制性食物摄入障碍(ARFID)儿童的功效/机制
- 批准号:
10212222 - 财政年份:2020
- 资助金额:
$ 66.97万 - 项目类别:
Confirming the Efficacy/Mechanism of Family Therapy for Children with Low Weight Avoidant/Restrictive Food Intake Disorder (ARFID)
确认家庭治疗对低体重回避/限制性食物摄入障碍(ARFID)儿童的功效/机制
- 批准号:
10427302 - 财政年份:2020
- 资助金额:
$ 66.97万 - 项目类别:
Confirming the Efficacy/Mechanism of Family Therapy for Children with Low Weight Avoidant/Restrictive Food Intake Disorder (ARFID)
确认家庭治疗对低体重回避/限制性食物摄入障碍(ARFID)儿童的功效/机制
- 批准号:
10682614 - 财政年份:2020
- 资助金额:
$ 66.97万 - 项目类别:
Confirming the Efficacy/Mechanism of Family Therapy for Children with Low Weight Avoidant/Restrictive Food Intake Disorder (ARFID)
确认家庭治疗对低体重回避/限制性食物摄入障碍(ARFID)儿童的功效/机制
- 批准号:
10039552 - 财政年份:2020
- 资助金额:
$ 66.97万 - 项目类别:
Confirming the Efficacy/Mechanism of an Adaptive Treatment for Adolescent Anorexia Nervosa
确认青少年神经性厌食症适应性治疗的功效/机制
- 批准号:
9884814 - 财政年份:2017
- 资助金额:
$ 66.97万 - 项目类别:
Optimizing a Smartphone Application for Individuals with Eating Disorders
为饮食失调患者优化智能手机应用程序
- 批准号:
9276789 - 财政年份:2016
- 资助金额:
$ 66.97万 - 项目类别:
Optimizing a Smartphone Application for Individuals with Eating Disorders
为饮食失调患者优化智能手机应用程序
- 批准号:
8982118 - 财政年份:2015
- 资助金额:
$ 66.97万 - 项目类别:
Feasibility of Combining Family and Cognitive Therapy to Prevent Chronic Anorexia
结合家庭和认知疗法预防慢性厌食症的可行性
- 批准号:
8569906 - 财政年份:2013
- 资助金额:
$ 66.97万 - 项目类别:
Feasibility of Combining Family and Cognitive Therapy to Prevent Chronic Anorexia
结合家庭和认知疗法预防慢性厌食症的可行性
- 批准号:
8701414 - 财政年份:2013
- 资助金额:
$ 66.97万 - 项目类别:
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