Feasibility of Combining Family and Cognitive Therapy to Prevent Chronic Anorexia

描述（由申请人提供）：神经性厌食症（AN）通常在青春期开始，是一种严重的精神疾病，与高发病率、死亡率和经济成本相关。虽然以家庭为基础的治疗（FBT）导致约50%的短期AN青少年完全和稳定的恢复，但对于那些没有反应的青少年没有基于证据的干预措施，因此，他们患慢性病的风险约为33%。因此，在有合理的成功机会的同时，必须进行干预，以改变有患慢性病风险的年轻患者的轨迹。本申请是对PA-12-279（R34）的回应，旨在研究将认知矫正疗法（CRT）与FBT相结合的可行性，以便将来在充分把握度的RCT中使用，以降低青少年发生持续性AN的风险。两项研究表明，较高水平的强迫性特征导致FBT的结果较差。有人建议，CRT解决了强迫性思维的认知基础，促进更灵活和更少的毅力思维。这些变化反过来可能导致接受维持AN的行为和思想变化的需要的能力提高。两个小型病例系列报告了成人AN的显著改善。此外，AN青少年的病例系列数据发现CRT是可接受的，并改善了认知过程。我们提出以下具体目标：目标1：研究将CRT纳入FBT的可行性。我们将检查FBT + CRT的可接受性、招募、评估程序和工具的可行性以及比较治疗（FBT + ART治疗）的可接受性。目标二：探讨接受FBT + CRT与FBT+艺术治疗相比，认知方式、体重、饮食相关认知和心理社会功能的变化。为了实现目标1，我们将招募30名青少年（年龄12-18岁），他们患有AN，并且在YBC-ED上有OC特征的证据（评分>14）。这些受试者将随机接受FBT（15次）+艺术练习（15次）6个月或FBT + CRT（15次）6个月。我们的主要成果是：招聘的可行性，保留率和评估程序的可行性。次要结局（目标2）是神经心理功能、体重、饮食相关精神病理学和心理社会功能的变化。将在四个时间点进行评估：基线、4周、8周和治疗结束（EOT）。

DESCRIPTION (provided by applicant): Anorexia Nervosa (AN) usually begins during adolescence and is a serious psychiatric disorder associated with high morbidity, mortality, and economic cost. Although Family-Based Treatment (FBT) leads to full and stable recovery in about 50% of adolescents with short duration AN, there are no evidence based interventions for those who do not respond and who, as a result, are at approximately 33% risk for becoming chronically ill. Therefore, it is imperative to intervene to change the trajectory of young patient at risk for becoming chronically ill while there is a reasonable opportunity for success. This application in response to PA-12-279 (R34) proposes to study the feasibility of combining Cognitive Remediation Therapy (CRT) with FBT for future use in an adequately powered RCT to reduce the risk of adolescents developing persistent AN. Two studies suggest that higher levels of obsessional features lead to poorer outcome in FBT. It is proposed that CRT addresses the cognitive underpinnings of obsessional thought by promoting more flexible and less perseverative thinking. These changes could in turn lead to an improved ability to accept the need for change in the behaviors and thoughts that maintain AN. Two small case series report significant improvement in adults with AN. In addition, case series data in adolescents with AN find CRT is acceptable and improves cognitive processes. We propose the following Specific Aims: Aim 1: To examine the feasibility of incorporating CRT in FBT. We will examine acceptability, recruitment, feasibility of assessment procedures and instruments of FBT plus CRT and the acceptability of the comparison treatment (FBT plus art therapy). Aim 2: To explore changes in cognitive style, weight, eating related cognitions, and psychosocial functioning in those who received FBT plus CRT compared to FBT plus art therapy. To accomplish Aim 1, we will recruit 30 adolescents (ages 12-18) with AN and evidence of OC features on the YBC-ED (score >14). These participants will be randomized to either FBT (15 sessions) plus art exercises (15 sessions) for 6 months or FBT plus CRT (15 sessions) for 6 months. Our primary outcomes are: feasibility of recruitment, retention rates, and viability of assessment procedures. Secondary outcomes (Aim 2) are changes in neuropsychological functioning, weight, eating related psychopathology and psychosocial functioning. Assessments will occur at four time points: baseline, 4 weeks, 8 weeks, and end of treatment (EOT).