MRI-compatible BrainPET Scanner

项目总结/摘要 该申请寻求NIMH的支持，以购买3特斯拉磁共振（MR）兼容 正电子发射断层扫描（PET）脑扫描仪，由Cubresa，Inc. PET和MRI是两种 目前用于研究人脑的最强大的成像模式。扫描仪能够 在人类受试者中同时进行PET和MR全身数据采集成为商业上可用的， 十年前然而，直到最近，市场上还没有等效的专用头部设备来解决 研究人员和临床医生的需求集中在大脑和全身设备的性能， 在这个目的上是有限的。Martinos安装的高性能MR兼容BrainPET扫描仪 该中心将有利于我们中心和社区的许多以大脑为中心的研究。库布雷萨酒店 BrainPET将取代2008年5月安装在Martinos中心的Siemens BrainPET原型 十多年来一直有效地为我们的调查人员服务。它被转移到了马蒂诺斯中心的PET 和放射化学设施，并成为我们的PET计划多年来，甚至 安装Biograph mMR后。在使用高峰期，有36个项目使用BrainPET 原型在各种研究，从那些旨在表征扫描仪的性能，开发 使用从一种设备获得的信息来改进另一种设备的方法，并证明 这项技术的巨大潜力，通过在非人类灵长类动物，健康， 志愿者和众多的患者群体。然而，随着PET探测器的飞速发展， 在过去的十年中，15岁以上的技术现在已经过时了。的服务协议 BrainPET原型于5年前结束，该原型在2021年约三分之一的时间里一直不起作用， 技术故障。因此，有必要更换这一陈旧过时的系统， 完成正在进行的项目的科学目标和目的，重点是几种精神疾病， 相关主题（即，焦虑症、自闭症谱系障碍、双相情感障碍、抑郁症、艾滋病毒/艾滋病和 精神健康、精神分裂症、药物使用、创伤事件）以及神经系统疾病和基本 神经科学新仪器的安装得到了MGH领导层的支持，放射学 部门和Martinos中心。这种多层次的机构支持包括分配仪器空间， 协助安装，在系统调度、会计和维护方面提供运营支持，以及 最后，承诺高达278，000美元，以弥补NIH SIG奖励与购买价格之间的差距 除了MGH执行委员会承诺的100，000美元资金外， Research.安装完成后，Cubresa BrainPET将由Martinos中心作为一个共享 核心，并提供给更广泛的研究界，无论是在MGH和大波士顿地区。

Project Summary/Abstract This application seeks support from NIMH to purchase the 3-Tesla magnetic resonance (MR)-compatible positron emission tomography (PET) brain scanner manufactured by Cubresa, Inc. PET and MRI are two of the most powerful imaging modalities currently in use for studying the human brain. Scanners capable of simultaneous PET and MR whole-body data acquisition in human subjects became commercially available a decade ago. However, until recently, there was no equivalent dedicated head device on the market to address the needs of the researchers and clinicians focusing on the brain and the performance of whole-body devices is rather limited for this purpose. A high-performance MR-compatible BrainPET scanner installed at the Martinos Center would benefit many brain-focused research studies in our center and in the community. The Cubresa BrainPET would replace the Siemens BrainPET prototype that was installed at the Martinos Center in May 2008 and has served our investigators effectively for more than a decade. It was moved in the Martinos Center PET & Radiochemistry Facility in June 2011 and became the workhorse of our PET program for many years even after the installation of the Biograph mMR. At peak usage, three-dozen projects were using the BrainPET prototype in a variety of studies ranging from those aimed at characterizing the scanner performance, developing methods to use the information obtained from one device to improve the other modality, and demonstrating the tremendous potential of this technology through proof-of-principle studies in non-human primates, healthy volunteers, and numerous patient populations. However, with the exceedingly fast PET detector developments seen in the last decade, the 15+ year old technology has now become outdated. The service agreement for the BrainPET prototype ended 5 years ago and the prototype has been non-functional for about a third of 2021 due to technical failures. Therefore, a replacement of this aging and obsolete system will be necessary to enhance and complete the scientific goals and aims of the ongoing projects focused on several mental disorders and related topics (i.e., anxiety disorders, autism spectrum disorder, bipolar disorder, depression, HIV/AIDS and mental health, schizophrenia, substance use, traumatic events) as well as on neurological diseases and basic neuroscience. The installation of the new instrument is being supported by the MGH leadership, Radiology Department, and Martinos Center. This multi-level institutional support covers allocation of instrument space and assistance for installation, operational support in terms of system scheduling, accounting, and maintenance, and lastly, a commitment of up to $278,000 to cover the gap between the NIH SIG award and the purchasing price for the upgrade, in addition to the committed funds of $100,000 from the MGH Executive Committee for Research. Following the installation, the Cubresa BrainPET will be managed by the Martinos Center as a shared core, and made available to the broader research community, both within MGH and the Greater Boston region.