MRI-compatible BrainPET Scanner

兼容 MRI 的 BrainPET 扫描仪

• 批准号: 10505319
• 负责人: Ciprian Catana
• 金额: $ 60万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10505319
• 关键词: 15 year old; AIDS/HIV problem; Accounting; Address; Aging; Agreement; Anxiety Disorders; Award; Bipolar Disorder; Boston; Brain; Communities; Development; Devices; Failure; Funding; Goals; Head; Human; Leadership; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Mental Depression; Mental Health; Mental disorders; Methods; Modality; National Institute of Mental Health; Neurosciences; Performance; Positron-Emission Tomography; Price; Radiochemistry; Radiology Specialty; Research; Research Personnel; Schedule; Schizophrenia; Services; System; Technology; United States National Institutes of Health; autism spectrum disorder; data acquisition; detector; healthy volunteer; human subject; imaging modality; improved; instrument; nervous system disorder; nonhuman primate; patient population; programs; prototype; research study; substance use; traumatic event

Project Summary/Abstract This application seeks support from NIMH to purchase the 3-Tesla magnetic resonance (MR)-compatible positron emission tomography (PET) brain scanner manufactured by Cubresa, Inc. PET and MRI are two of the most powerful imaging modalities currently in use for studying the human brain. Scanners capable of simultaneous PET and MR whole-body data acquisition in human subjects became commercially available a decade ago. However, until recently, there was no equivalent dedicated head device on the market to address the needs of the researchers and clinicians focusing on the brain and the performance of whole-body devices is rather limited for this purpose. A high-performance MR-compatible BrainPET scanner installed at the Martinos Center would benefit many brain-focused research studies in our center and in the community. The Cubresa BrainPET would replace the Siemens BrainPET prototype that was installed at the Martinos Center in May 2008 and has served our investigators effectively for more than a decade. It was moved in the Martinos Center PET & Radiochemistry Facility in June 2011 and became the workhorse of our PET program for many years even after the installation of the Biograph mMR. At peak usage, three-dozen projects were using the BrainPET prototype in a variety of studies ranging from those aimed at characterizing the scanner performance, developing methods to use the information obtained from one device to improve the other modality, and demonstrating the tremendous potential of this technology through proof-of-principle studies in non-human primates, healthy volunteers, and numerous patient populations. However, with the exceedingly fast PET detector developments seen in the last decade, the 15+ year old technology has now become outdated. The service agreement for the BrainPET prototype ended 5 years ago and the prototype has been non-functional for about a third of 2021 due to technical failures. Therefore, a replacement of this aging and obsolete system will be necessary to enhance and complete the scientific goals and aims of the ongoing projects focused on several mental disorders and related topics (i.e., anxiety disorders, autism spectrum disorder, bipolar disorder, depression, HIV/AIDS and mental health, schizophrenia, substance use, traumatic events) as well as on neurological diseases and basic neuroscience. The installation of the new instrument is being supported by the MGH leadership, Radiology Department, and Martinos Center. This multi-level institutional support covers allocation of instrument space and assistance for installation, operational support in terms of system scheduling, accounting, and maintenance, and lastly, a commitment of up to $278,000 to cover the gap between the NIH SIG award and the purchasing price for the upgrade, in addition to the committed funds of $100,000 from the MGH Executive Committee for Research. Following the installation, the Cubresa BrainPET will be managed by the Martinos Center as a shared core, and made available to the broader research community, both within MGH and the Greater Boston region.

项目摘要/摘要 此应用程序寻求NIMH的支持，以购买兼容3特斯拉磁共振(MR)的 Cubresa公司生产的正电子发射断层扫描(PET)脑扫描仪是其中的两种 目前用于研究人脑的最强大的成像设备。具有以下功能的扫描仪 在人类受试者中同时进行正电子发射计算机断层扫描和磁共振全身数据采集成为商业上可用的方法 十年前。然而，直到最近，市场上还没有同等的专用头盔来解决 专注于大脑和全身设备性能的研究人员和临床医生的需求是 对于这个目的来说相当有限。安装在Martinos酒店的高性能MR兼容BrainPET扫描仪 中心将使我们中心和社区中许多以大脑为重点的研究受益。《立方体》 BrainPET将取代2008年5月安装在Martinos中心的西门子BrainPET原型 十多年来一直有效地为我们的调查人员服务。它被移到了马提诺斯中心的PET 和放射化学设施，并成为我们的PET计划多年来的主力甚至 在安装Bioggraph MMR之后。在使用高峰期，有36个项目在使用BrainPET 各种研究中的原型，从那些旨在表征扫描仪性能的研究，开发 方法使用从一个设备获得的信息来改进另一个设备，并演示 通过对非人类灵长类动物的原理验证研究，这项技术具有巨大的潜力， 志愿者和众多的患者群体。然而，随着PET探测器的超快发展 在过去的十年里，这项有15年以上历史的技术现在已经过时了。的服务协议 BrainPET原型于5年前结束，该原型已在2021年的约三分之一时间内无法使用 到技术故障。因此，有必要更换这一老化和过时的系统，以加强 并完成正在进行的项目的科学目标和目的，这些项目侧重于几种精神障碍和 相关主题(即焦虑症、自闭症谱系障碍、躁郁症、抑郁症、艾滋病毒/艾滋病和 精神健康、精神分裂症、药物使用、创伤事件)以及神经疾病和基础知识 神经科学。新仪器的安装得到了MGH放射科领导的支持 部门和马蒂诺斯中心。这种多层次的制度支持涵盖了仪器空间的分配和 协助安装，在系统调度、会计和维护方面提供运营支持，以及 最后，承诺高达278,000美元，以弥补NIH SIG奖励和购买价格之间的差距 对于升级，除了MGH执行委员会承诺的100,000美元资金外， 研究。安装后，Cubresa BrainPET将由Martinos中心作为共享 核心，并提供给更广泛的研究社区，在MGH和大波士顿地区。