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Development of the Human Dynamic Neurochemical Connectome Scanner

人体动态神经化学连接组扫描仪的开发

基本信息

批准号：
10644028
负责人：
Ciprian Catana
金额：
$ 104.4万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-21 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10644028
关键词：
Address Algorithms Area BRAIN initiative Brain Brain imaging Categories Cell Nucleus Central Nervous System Diseases Characteristics Cognition Collaborations Computer software Data Dedications Development Devices Disease Dopamine Receptor Dose Elements Event Floods Functional Magnetic Resonance Imaging Geometry Goals Hand Head Human Image Link Magnetic Resonance Magnetic Resonance Imaging Marketing Mechanics Methods Molecular Molecular Target Noise Performance Peripheral Photons Physiology Positron-Emission Tomography Process Quality Control Receptor Signaling Research Personnel Resolution Rest Running Signal Transduction Structure System Systems Integration Technology Testing Time Work cognitive process connectome data acquisition desensitization design detector experimental study glucose metabolism healthy volunteer hemodynamics human subject image reconstruction imaging modality improved infancy insight magnetic field molecular dynamics neurochemistry neuropsychiatry neuroregulation neurotransmission next generation novel pharmacologic prototype spatiotemporal temporal measurement visual stimulus

项目摘要

Project Summary We seek support to develop and build the next generation 7-Tesla magnetic resonance (MR)-compatible positron emission tomography (PET) brain scanner with dramatically improved spatiotemporal resolution (HSTR-BrainPET). PET and MRI are two of the most powerful imaging modalities currently in use for studying the human brain. Recently, scanners capable of simultaneous PET and MR whole-body data acquisition in human subjects have become commercially available. However, there is no equivalent dedicated head device on the market to address the needs of the researchers and clinicians focusing on the brain and the performance of whole-body devices is rather limited for this purpose. More importantly, although current PET technology achieves high molecular sensitivity with a broad set of probes for neurochemical targets, PET still lacks the capability to track dynamic changes in a time scale comparable to functional processes. Our main goal is to build an MR-compatible PET camera with very high sensitivity to enable truly dynamic PET imaging of brain neurotransmission. One of the first MR-compatible brain PET prototypes was installed at the Martinos Center in 2008 when human PET/MR imaging was in its infancy. Following a close collaboration with Siemens to address the remaining technical challenges, proof-of-principle PET/MR studies demonstrating the advantages and potential of this novel imaging modality were performed. A decade later, a new type of photon detector technology has reached a level of maturity that would allow us to build the next generation integrated system with dramatically improved spatiotemporal resolution. We propose to address the hardware and software challenges in building 7-T MR-compatible PET technology purpose-built to extend the temporal window of PET down to just a few seconds. Additionally, the substantial improvement in spatial resolution will also allow for imaging of cortical substructures and nuclei that cannot be resolved with current state-of-the-art devices. Specifically, we propose to: (1) Build the hardware components of the HSTR-BrainPET insert, integrate it with the 7-T MR scanner and characterize the combined device; (2) Implement the software for PET data acquisition, processing and image reconstruction adapted to the non-conventional geometry we are proposing; (3) Apply the integrated scanner to dynamic assessment of neurochemical events and brain activation in healthy human subjects. !

项目概要我们寻求支持来开发和构建下一代 7-Tesla 磁共振 (MR) 兼容设备时空分辨率显着提高的正电子发射断层扫描 (PET) 脑部扫描仪（HSTR-BrainPET）。 PET 和 MRI 是目前用于研究的两种最强大的成像方式人类的大脑。最近，能够同时采集 PET 和 MR 全身数据的扫描仪人类受试者已经商业化。然而，没有等效的专用头设备市场上以满足研究人员和临床医生关注大脑和为此目的，全身设备的性能相当有限。更重要的是，虽然目前的PET 技术通过针对神经化学靶标的广泛探针实现了高分子灵敏度，PET 仍然缺乏在与功能流程相当的时间范围内跟踪动态变化的能力。我们的主要目标是构建具有极高灵敏度的 MR 兼容 PET 相机，以实现真正的动态 PET 成像大脑神经传递。第一个 MR 兼容的大脑 PET 原型安装在 Martinos 该中心于 2008 年成立，当时人类 PET/MR 成像还处于起步阶段。与西门子密切合作后为了解决剩余的技术挑战，原理验证 PET/MR 研究证明了展示了这种新型成像方式的优点和潜力。十年后，一种新型光子探测器技术已达到成熟水平，使我们能够构建下一代集成探测器系统的时空分辨率显着提高。我们建议解决硬件和构建专门用于延长时间的 7-T MR 兼容 PET 技术的软件挑战 PET 窗口缩短至仅几秒钟。此外，空间分辨率的显着提高将还可以对当前最先进技术无法解决的皮质亚结构和细胞核进行成像设备。具体来说，我们建议：（1）构建 HSTR-BrainPET 插入物的硬件组件，将其与 7-T MR 扫描仪集成并表征组合设备； (2) 实现PET软件适应非常规几何形状的数据采集、处理和图像重建提议； (3) 将集成扫描仪应用于神经化学事件和大脑的动态评估健康人类受试者中的激活。！