Development of 7-T MR-compatible TOF-DOI PET Detector and System Technology for the Human Dynamic Neurochemical Connectome Scanner

开发用于人体动态神经化学连接组扫描仪的 7-T MR 兼容 TOF-DOI PET 探测器和系统技术

• 批准号: 9789281
• 负责人: Ciprian Catana
• 金额: $ 48.02万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9789281
• 关键词: Address; Brain; Brain imaging; Categories; Central Nervous System Diseases; Cognition; Collaborations; Consumption; Coupling; Data; Detection; Development; Devices; Disease; Electronics; Elements; Ensure; Event; Floods; Generations; Geometry; Goals; Head; Human; Immunity; Light; Link; Magnetic Resonance; Magnetic Resonance Imaging; Mechanics; Methods; Molecular; Molecular Target; Noise; Optics; Output; Performance; Photons; Physiology; Positron-Emission Tomography; Process; Research Personnel; Resolution; Signal Transduction; Silicon; Structure; Surface; System; Technology; Temperature; Testing; Time; Update; Work; base; cognitive process; connectome; cost effective; data acquisition; design; detector; experimental study; flexibility; hemodynamics; human subject; imaging modality; improved; infancy; insight; interest; neurochemistry; neuropsychiatry; neuroregulation; neurotransmission; next generation; novel; operation; photomultiplier; prototype; radio frequency; scale up; signal processing; simulation; spatiotemporal; temporal measurement

Project Summary We seek support to develop and build the positron emission tomography (PET) detector module for the next generation 7-Tesla magnetic resonance (MR)-compatible PET brain scanner with dramatically improved spatio-temporal resolution. PET and MRI are two of the most powerful imaging modalities currently in use for studying the human brain. Recently, scanners capable of simultaneous PET and MR whole-body data acquisition in human subjects have become commercially available. However, there is no equivalent dedicated head device on the market to address the needs of the researchers and clinicians focusing on the brain and the performance of whole-body devices is rather limited for this purpose. More importantly, although current PET technology achieves high molecular sensitivity with a broad set of probes for neurochemical targets, PET still lacks the capability to track dynamic changes in a time scale comparable to functional processes. Our long-term goal is to build an MR-compatible PET camera with very high sensitivity to enable truly dynamic PET imaging of brain neurotransmission. One of the first MR-compatible brain PET prototypes was installed at the Martinos Center in 2008 when human PET/MR imaging was in its infancy. Following a close collaboration with Siemens to address the remaining technical challenges, proof-of-principle PET/MR studies demonstrating the advantages and potential of this novel imaging modality were performed. Almost a decade later, a new type of photon detector technology has reached a level of maturity that would allow us to build the next generation integrated system with dramatically improved spatiotemporal resolution. As first steps towards achieving this goal, we propose to design, build and evaluate a high performance PET detector module and begin to address the system-level integration challenges. Specifically, we will: (1) develop a depth-of-interaction and time-of- flight capable scintillator array using a practical approach; (2) design, build and evaluate a scalable 7-T MR- compatible silicon photomultiplier based PET detector module; and (3) investigate and address the system- level hardware challenges for a non-standard PET scanner geometry. !

项目摘要 我们寻求支持，以开发和构建下一代正电子发射断层扫描（PET）探测器模块 第七代兼容7特斯拉磁共振（MR）的PET脑部扫描仪， 时空分辨率PET和MRI是目前用于诊断的两种最强大的成像模式。 研究人类大脑。最近，能够同步PET和MR全身数据的扫描仪 在人类受试者中的获得已经变得可商购。但是，没有相应的专用 市场上的头部设备，以满足研究人员和临床医生的需要，重点放在大脑和 全身装置的性能对于该目的是相当有限的。更重要的是，虽然目前 PET技术通过一系列针对神经化学靶点的探针实现了高分子灵敏度， 仍然缺乏在与功能过程可比的时间尺度上跟踪动态变化的能力。我们 长期目标是建立一个MR兼容PET相机具有非常高的灵敏度，使真正的动态PET 脑神经传递的成像。第一个MR兼容的大脑PET原型之一安装在 Martinos中心于2008年在人体PET/MR成像处于起步阶段时进行了研究。在与 西门子解决剩余的技术挑战，PET/MR原理验证研究证明， 的优点和潜力，这种新的成像模式进行。近十年后，一种新型的 光子探测器技术已经达到了一个成熟的水平，使我们能够建立下一代 集成系统，大大提高了时空分辨率。作为实现这一目标的第一步， 目标，我们建议设计，建立和评估高性能PET探测器模块，并开始解决 系统级集成的挑战。具体而言，我们将：（1）制定一个互动的深度和时间- 飞行能力闪烁体阵列使用实用的方法;（2）设计，建立和评估一个可扩展的7-T MR- 兼容的基于硅光电倍增管的PET探测器模块;以及（3）调查和解决系统- 对于非标准PET扫描仪几何结构， !